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An Introduction to Systems Biology: Design Principles of Biological Circuits (Chapman & Hall/CRC Mathematical & Computational Biology)

by: Uri Alon
(07 July 2006)

X Abstract

Thorough and accessible, this book presents the design principles of biological systems, and highlights the recurring circuit elements that make up biological networks. It provides a simple mathematical framework which can be used to understand and even design biological circuits. The textavoids specialist terms, focusing instead on several well-studied biological systems that concisely demonstrate key principles. **An Introduction to Systems Biology: Design Principles of Biological Circuits **builds a solid foundation for the intuitive understanding of general principles. It encourages the reader to ask _why_ a system is designed in a particular way and then proceeds to answer with simplified models.

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This article has been bookmarked 23 times, initially on 2007-05-21.

2009-11-18 Group Systems_Biology
Group Computational_Systems_Biology
User Sergey_gerbek
2009-11-09 User dbikard
2009-08-03 User fastjoe23
2009-07-04 User bertelsen
2009-06-20 User ilyashl
2009-04-30 User Scis0000002
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2007-10-25 User aalibes
2007-10-09 User fishtank
2007-07-16 User mattjb , 1 note

Robustness is considered in the case of bacterial chemotaxis, and also in development, key to this robustness is negative feedback, which brings bacteria back to original state after step impulse, etc., ie nothing new here.

Looks at some simple network motifs (cross between social network diads, triads and some basic control / boolean logic).

Demand rule of Savageau: “positive mode of regulation is more stable against mutations in a high demand environment, and the negative mode is more stable against mutations in a low demand environment."

2007-07-16 08:18:28
Group ComplexAdaptiveSystems
Group DSTO-CAS
2007-05-21 User balajis
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