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Sic transit gloria: farewell to the epidermal transit amplifying cell?

by: P. H. Jones, B. D. Simons, F. M. Watt
Cell stem cell, Vol. 1, No. 4. (11 October 2007), pp. 371-381.

X Abstract

For the past 30 years, the prevailing model of epidermal homeostasis has been that epidermal stem cells give rise to transit amplifying cells, which undergo a limited number of cell divisions before initiating terminal differentiation. Recent studies challenge the existence of a transit amplifying cell compartment and suggest a new paradigm for epidermal homeostasis.

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