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Haplotype blocks and linkage disequilibrium in the human genome.

by: J. D. Wall, J. K. Pritchard
Nature reviews. Genetics, Vol. 4, No. 8. (August 2003), pp. 587-597.

X Abstract

There is great interest in the patterns and extent of linkage disequilibrium (LD) in humans and other species. Characterizing LD is of central importance for gene-mapping studies and can provide insights into the biology of recombination and human demographic history. Here, we review recent developments in this field, including the recently proposed 'haplotype-block' model of LD. We describe some of the recent data in detail and compare the observed patterns to those seen in simulations.

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