Poised RNA polymerase II gives pause for thought.

Anthony read this a couple weeks ago and added to citeulike and I also saw it cited in the recent Espinosa review. Looks like a great minireview that I want to read. It's a minireview of the recent genome-wide analyses showing wide-spread PPEP (promoter-proximal elongating polymerases). Including from our friend Adelman's lab.

This is a review paper that discusses the most recent research done in relation to promoter proximal pausing of RNA Pol II. It discusses how genome wide studies have shown that there are a larger number of genes that had paused polymerase than the few exceptions (like HSP genes). Elongation is more regulated than just prior to initiation or even the recruitment of RNA Pol II. The authors then pose a series of questions that still need to be solved for further understanding of the subject. Questions to which I could possibly answer...