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FANCF methylation contributes to chemoselectivity in ovarian cancer.

by: O. I. Olopade, M. Wei
Cancer cell, Vol. 3, No. 5. (May 2003), pp. 417-420.

X Abstract

A new model of ovarian cancer tumor progression implicates aberrant FANCF promoter methylation that is associated with gene silencing and disruption of the Fanconi-anemia-BRCA pathway. Disruption of the pathway occurs de novo in ovarian cancers and may contribute to selective sensitivity to platinum salts.

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