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Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories.

by: N. Plath, O. Ohana, B. Dammermann, M. L. Errington, D. Schmitz, C. Gross, X. Mao, A. Engelsberg, C. Mahlke, H. Welzl, U. Kobalz, A. Stawrakakis, E. Fernandez, R. Waltereit, A. Bick-Sander, E. Therstappen, S. F. Cooke, V. Blanquet, W. Wurst, B. Salmen, M. R. Bösl, H. P. Lipp, S. G. Grant, T. V. Bliss, D. P. Wolfer, D. Kuhl
Neuron, Vol. 52, No. 3. (9 November 2006), pp. 437-444.

X Abstract

Arc/Arg3.1 is robustly induced by plasticity-producing stimulation and specifically targeted to stimulated synaptic areas. To investigate the role of Arc/Arg3.1 in synaptic plasticity and learning and memory, we generated Arc/Arg3.1 knockout mice. These animals fail to form long-lasting memories for implicit and explicit learning tasks, despite intact short-term memory. Moreover, they exhibit a biphasic alteration of hippocampal long-term potentiation in the dentate gyrus and area CA1 with an enhanced early and absent late phase. In addition, long-term depression is significantly impaired. Together, these results demonstrate a critical role for Arc/Arg3.1 in the consolidation of enduring synaptic plasticity and memory storage.

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This article has been bookmarked 2 times, initially on 2006-11-09.

2007-09-27 User pgastrein
2006-11-09 User fluomouse
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