Changes in body mass index, leptin and adiponectin in Japanese children during a three-year follow-up period: a population-based cohort study. Export

@article{citeulike:4746393, abstract = {OBJECTIVE: The study examined changes in and relationship between body mass index (BMI), leptin and adiponectin levels over a 3-year period in a pediatric population-based cohort. STUDY DESIGN: A 3-year prospective cohort study of 268 boys and 251 girls aged 9-10 in Ina, Saitama, Japan. RESULTS: Median body mass index (BMI) significantly increased from baseline (age 9-10) to follow up (age 12-13) in boys from 17.1 to 18.3 kg/m2 (P < 0.001) and in girls from 16.5 to 18.5 kg/m2 (P < 0.001), respectively. Adiponectin values significantly decreased from baseline to follow up in boys (13.5 to 8.9 microg/ml, respectively) (P < 0.001) and in girls (12.4 to 9.5 microg/ml, respectively) (P < 0.001). Leptin values at follow up significantly decreased from baseline in boys (4.9 to 2.3 ng/dl, respectively) (P < 0.001) and also in girls (5.3 to 5.1 ng/dl, respectively) (P = 0.049). A relatively strong correlation was seen in BMI (Spearman's correlation coefficient, r = 0.864, P < 0.001 in boys; r = 0.873, P < 0.001 in girls), adiponectin (r = 0.705, P < 0.001 in boys; r = 0.695, P < 0.001 in girls), and leptin (r = 0.449, P < 0.001 in boys; r = 0.610, P < 0.001 in girls) before and after the three-year period. The ratio of follow up to baseline BMI was negatively correlated with that for adiponectin (r = -0.224, P < 0.001 in boys; r = -0.165, P = 0.001 in girls) and positively correlated with that for leptin (r = 0.518, P < 0.001 in boys; r = 0.609, P < 0.001 in girls). CONCLUSION: This study demonstrated that baseline adiponectin, leptin and BMI values measured at ages 9-10 correlated with those measured three years later. However, adiponectin values decreased and leptin values increased in those subjects whose BMI increased during over this period.}, author = {Nishimura, Rimei and Sano, Hironari and Matsudaira, Toru and Morimoto, Aya and Miyashita, Yumi and Shirasawa, Takako and Kokaze, Akatsuki and Tajima, Naoko}, citeulike-article-id = {4746393}, citeulike-linkout-0 = {http://dx.doi.org/10.1186/1475-2840-8-30}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19490650}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19490650}, day = {03}, doi = {10.1186/1475-2840-8-30}, issn = {1475-2840}, journal = {Cardiovascular diabetology}, month = {June}, pages = {30+}, posted-at = {2009-06-04 17:40:23}, title = {Changes in body mass index, leptin and adiponectin in Japanese children during a three-year follow-up period: a population-based cohort study.}, url = {http://dx.doi.org/10.1186/1475-2840-8-30}, volume = {8}, year = {2009} }

TY - JOUR ID - citeulike:4746393 L3 - citeulike-article-id:4746393 N2 - OBJECTIVE: The study examined changes in and relationship between body mass index (BMI), leptin and adiponectin levels over a 3-year period in a pediatric population-based cohort. STUDY DESIGN: A 3-year prospective cohort study of 268 boys and 251 girls aged 9-10 in Ina, Saitama, Japan. RESULTS: Median body mass index (BMI) significantly increased from baseline (age 9-10) to follow up (age 12-13) in boys from 17.1 to 18.3 kg/m2 (P < 0.001) and in girls from 16.5 to 18.5 kg/m2 (P < 0.001), respectively. Adiponectin values significantly decreased from baseline to follow up in boys (13.5 to 8.9 microg/ml, respectively) (P < 0.001) and in girls (12.4 to 9.5 microg/ml, respectively) (P < 0.001). Leptin values at follow up significantly decreased from baseline in boys (4.9 to 2.3 ng/dl, respectively) (P < 0.001) and also in girls (5.3 to 5.1 ng/dl, respectively) (P = 0.049). A relatively strong correlation was seen in BMI (Spearman's correlation coefficient, r = 0.864, P < 0.001 in boys; r = 0.873, P < 0.001 in girls), adiponectin (r = 0.705, P < 0.001 in boys; r = 0.695, P < 0.001 in girls), and leptin (r = 0.449, P < 0.001 in boys; r = 0.610, P < 0.001 in girls) before and after the three-year period. The ratio of follow up to baseline BMI was negatively correlated with that for adiponectin (r = -0.224, P < 0.001 in boys; r = -0.165, P = 0.001 in girls) and positively correlated with that for leptin (r = 0.518, P < 0.001 in boys; r = 0.609, P < 0.001 in girls). CONCLUSION: This study demonstrated that baseline adiponectin, leptin and BMI values measured at ages 9-10 correlated with those measured three years later. However, adiponectin values decreased and leptin values increased in those subjects whose BMI increased during over this period. JF - Cardiovascular diabetology SN - 1475-2840 TI - Changes in body mass index, leptin and adiponectin in Japanese children during a three-year follow-up period: a population-based cohort study. VL - 8 SP - 30 AU - Nishimura, Rimei AU - Sano, Hironari AU - Matsudaira, Toru AU - Morimoto, Aya AU - Miyashita, Yumi AU - Shirasawa, Takako AU - Kokaze, Akatsuki AU - Tajima, Naoko PY - 2009/06/03/ UR - http://dx.doi.org/10.1186/1475-2840-8-30 ER -