Parental diabetes status reveals association of mitochondrial DNA haplogroup J1 with type 2 diabetes Export

@article{citeulike:4934868, abstract = {Background:\&\#10;Although mitochondrial dysfunction is consistently manifested in patients with Type 2 Diabetes mellitus (T2DM), the association of mitochondrial DNA (mtDNA) sequence variants with T2DM varies among populations. These differences might stem from differing environmental influences among populations. However, other potentially important considerations emanate from the very nature of mitochondrial genetics, namely the notable high degree of partitioning in the distribution of human mtDNA variants among populations, as well as the interaction of mtDNA and nuclear DNA-encoded factors working in concert to govern mitochondrial function. We hypothesized that association of mtDNA genetic variants with T2DM could be revealed while controlling for the effect of additional inherited factors, reflected in family history information.\&\#10;Methods:\&\#10;To test this hypothesis we set out to investigate whether mtDNA genetic variants will be differentially associated with T2DM depending on the diabetes status of the parents. To this end, association of mtDNA genetic backgrounds (haplogroups) with T2DM was assessed in 1055 Jewish patients with and without T2DM parents ('DP' and 'HP', respectively).\&\#10;Results:\&\#10;Haplogroup J1 was found to be 2.4 fold under-represented in the 'HP' patients (p=0.0035). These results are consistent with a previous observation made in Finnish T2DM patients. Moreover, assessing the haplogroup distribution in 'DP' versus 'HP' patients having diabetic siblings revealed that haplogroup J1 was virtually absent in the 'HP' group.\&\#10;Conclusions:\&\#10;These results imply the involvement of inherited factors, which modulate the susceptibility of haplogroup J1 to T2DM.}, author = {Feder, Jeanette and Ovadia, Ofer and Blech, Ilana and Cohen, Josef and Wainstein, Julio and Harman-Boehm, Ilana and Glaser, Benjamin and Mishmar, Dan}, citeulike-article-id = {4934868}, citeulike-linkout-0 = {http://dx.doi.org/10.1186/1471-2350-10-60}, doi = {10.1186/1471-2350-10-60}, issn = {1471-2350}, journal = {BMC Medical Genetics}, month = {June}, pages = {60+}, posted-at = {2009-06-23 17:25:42}, title = {Parental diabetes status reveals association of mitochondrial DNA haplogroup J1 with type 2 diabetes}, url = {http://dx.doi.org/10.1186/1471-2350-10-60}, volume = {10}, year = {2009} }

TY - JOUR ID - citeulike:4934868 L3 - citeulike-article-id:4934868 N2 - Background:
Although mitochondrial dysfunction is consistently manifested in patients with Type 2 Diabetes mellitus (T2DM), the association of mitochondrial DNA (mtDNA) sequence variants with T2DM varies among populations. These differences might stem from differing environmental influences among populations. However, other potentially important considerations emanate from the very nature of mitochondrial genetics, namely the notable high degree of partitioning in the distribution of human mtDNA variants among populations, as well as the interaction of mtDNA and nuclear DNA-encoded factors working in concert to govern mitochondrial function. We hypothesized that association of mtDNA genetic variants with T2DM could be revealed while controlling for the effect of additional inherited factors, reflected in family history information.
Methods:
To test this hypothesis we set out to investigate whether mtDNA genetic variants will be differentially associated with T2DM depending on the diabetes status of the parents. To this end, association of mtDNA genetic backgrounds (haplogroups) with T2DM was assessed in 1055 Jewish patients with and without T2DM parents ('DP' and 'HP', respectively).
Results:
Haplogroup J1 was found to be 2.4 fold under-represented in the 'HP' patients (p=0.0035). These results are consistent with a previous observation made in Finnish T2DM patients. Moreover, assessing the haplogroup distribution in 'DP' versus 'HP' patients having diabetic siblings revealed that haplogroup J1 was virtually absent in the 'HP' group.
Conclusions:
These results imply the involvement of inherited factors, which modulate the susceptibility of haplogroup J1 to T2DM. JF - BMC Medical Genetics SN - 1471-2350 TI - Parental diabetes status reveals association of mitochondrial DNA haplogroup J1 with type 2 diabetes VL - 10 SP - 60 AU - Feder, Jeanette AU - Ovadia, Ofer AU - Blech, Ilana AU - Cohen, Josef AU - Wainstein, Julio AU - Harman-Boehm, Ilana AU - Glaser, Benjamin AU - Mishmar, Dan PY - 2009/06/18/ UR - http://dx.doi.org/10.1186/1471-2350-10-60 ER -