Association study of SHANK3 gene polymorphisms with autism in Chinese Han population Export

@article{citeulike:5028371, abstract = {Background:\&\#10;Autism, a heterogeneous disease, is described as a genetic psychiatry disorder. Recently, abnormalities at the synapse are supposed to be important for the etiology of autism. SHANK3 (SH3 and multiple ankyrin repeat domains protein) gene encodes a master synaptic scaffolding protein at postsynaptic density (PSD) of excitatory synapse. Rare mutations and copy number variation (CNV) evidence suggested SHANK3 as a strong candidate gene for the pathogenesis of autism.\&\#10;Methods:\&\#10;We performed an association study between SHANK3 gene polymorphisms and autism in Chinese Han population. We analyzed the association between five single nucleotide polymorphisms (SNPs) of the SHANK3 gene and autism in 305 Chinese Han trios, using the family based association test (FBAT). Linkage disequilibrium (LD) analysis showed the presence of LD between pairwise markers across the locus. We also performed mutation screening for the rare de novo mutations reported previously.\&\#10;Results:\&\#10;No significant evidence between any SNPs of SHANK3 and autism was observed. We did not detect any mutations described previously in our cohort.\&\#10;Conclusions:\&\#10;We suggest that SHANK3 might not represent a major susceptibility gene for autism in Chinese Han population.}, author = {Qin, Jian and Jia, Meixiang and Wang, Lifang and Lu, Tianlan and Ruan, Yan and Liu, Jing and Guo, Yanqing and Zhang, Jishui and Yang, Xiaoling and Yue, Weihua and Zhang, Dai}, citeulike-article-id = {5028371}, citeulike-linkout-0 = {http://dx.doi.org/10.1186/1471-2350-10-61}, doi = {10.1186/1471-2350-10-61}, issn = {1471-2350}, journal = {BMC Medical Genetics}, month = {June}, pages = {61+}, posted-at = {2009-07-01 01:48:43}, title = {Association study of SHANK3 gene polymorphisms with autism in Chinese Han population}, url = {http://dx.doi.org/10.1186/1471-2350-10-61}, volume = {10}, year = {2009} }

TY - JOUR ID - citeulike:5028371 L3 - citeulike-article-id:5028371 N2 - Background:
Autism, a heterogeneous disease, is described as a genetic psychiatry disorder. Recently, abnormalities at the synapse are supposed to be important for the etiology of autism. SHANK3 (SH3 and multiple ankyrin repeat domains protein) gene encodes a master synaptic scaffolding protein at postsynaptic density (PSD) of excitatory synapse. Rare mutations and copy number variation (CNV) evidence suggested SHANK3 as a strong candidate gene for the pathogenesis of autism.
Methods:
We performed an association study between SHANK3 gene polymorphisms and autism in Chinese Han population. We analyzed the association between five single nucleotide polymorphisms (SNPs) of the SHANK3 gene and autism in 305 Chinese Han trios, using the family based association test (FBAT). Linkage disequilibrium (LD) analysis showed the presence of LD between pairwise markers across the locus. We also performed mutation screening for the rare de novo mutations reported previously.
Results:
No significant evidence between any SNPs of SHANK3 and autism was observed. We did not detect any mutations described previously in our cohort.
Conclusions:
We suggest that SHANK3 might not represent a major susceptibility gene for autism in Chinese Han population. JF - BMC Medical Genetics SN - 1471-2350 TI - Association study of SHANK3 gene polymorphisms with autism in Chinese Han population VL - 10 SP - 61 AU - Qin, Jian AU - Jia, Meixiang AU - Wang, Lifang AU - Lu, Tianlan AU - Ruan, Yan AU - Liu, Jing AU - Guo, Yanqing AU - Zhang, Jishui AU - Yang, Xiaoling AU - Yue, Weihua AU - Zhang, Dai PY - 2009/06/30/ UR - http://dx.doi.org/10.1186/1471-2350-10-61 ER -