The Capsule Drug Device: Novel Approach for Drug Delivery to the Eye Export

@article{citeulike:6004749, abstract = {Treatment of age macular degeneration requires monthly intravitreal injections, which are costly and have serious risks. The objective of this study was to develop a novel intraocular implant for drug delivery. The capsule drug ring is a reservoir inserted in the lens capsule during cataract surgery, refillable and capable of delivering multiple drugs. Avastin® was the drug of interest in this study. Prototypes were manufactured using polymethylmethacrylate sheets as the reservoir material, a semipermeable membrane for controlled delivery and silicone check valves for refilling. The device showed near-zero-order release kinetics and Avastin® stability was investigated with accelerated temperature studies.}, author = {Molokhia, Sarah A. and Sant, Himanshu and Simonis, Jacquelyn and Bishop, C. J. and Burr, R. M. and Gale, Bruce K. and Ambati, Balamurali}, citeulike-article-id = {6004749}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.visres.2009.10.013}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0042698909004775}, day = {23}, doi = {10.1016/j.visres.2009.10.013}, issn = {00426989}, journal = {Vision Research}, month = {October}, posted-at = {2009-10-25 07:03:21}, title = {The Capsule Drug Device: Novel Approach for Drug Delivery to the Eye}, url = {http://dx.doi.org/10.1016/j.visres.2009.10.013}, year = {2009} }

TY - JOUR ID - citeulike:6004749 L3 - citeulike-article-id:6004749 N2 - Treatment of age macular degeneration requires monthly intravitreal injections, which are costly and have serious risks. The objective of this study was to develop a novel intraocular implant for drug delivery. The capsule drug ring is a reservoir inserted in the lens capsule during cataract surgery, refillable and capable of delivering multiple drugs. Avastin® was the drug of interest in this study. Prototypes were manufactured using polymethylmethacrylate sheets as the reservoir material, a semipermeable membrane for controlled delivery and silicone check valves for refilling. The device showed near-zero-order release kinetics and Avastin® stability was investigated with accelerated temperature studies. JF - Vision Research SN - 00426989 TI - The Capsule Drug Device: Novel Approach for Drug Delivery to the Eye AU - Molokhia, Sarah AU - Sant, Himanshu AU - Simonis, Jacquelyn AU - Bishop, CJ AU - Burr, RM AU - Gale, Bruce AU - Ambati, Balamurali PY - 2009/10/23/ UR - http://dx.doi.org/10.1016/j.visres.2009.10.013 ER -