Panaxatriol saponins extracted from Panax notoginseng induces thioredoxin-1 and prevents 1-methyl-4-phenylpyridinium ion-induced neurotoxicity Export

@article{citeulike:6045345, abstract = {Thioredoxin-1 has various biologic activities, including the control of redox balance and the inhibition of apoptosis. It has been reported that thioredoxin-1 and its inducers are beneficial for neuroprotection against oxidative stress-associated neural diseases. In this study, we found panaxatriol saponins (PTS) extracted from Panax notoginseng as a new inducer of thioredoxin-1. PTS attenuated 1-methyl-4-phenylpyridinium ion-induced cell death of PC12 cells. These results indicate PTS has a possible potential as a therapeutic agent for neurodegenerative diseases including Parkinson's disease.}, author = {Luo, Fucheng and Wang, Shengdong and Li, Kui and Nakamura, Hajime and Yodoi, Junji and Bai, Jie}, citeulike-article-id = {6045345}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.jep.2009.10.023}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0378874109006795}, day = {24}, doi = {10.1016/j.jep.2009.10.023}, issn = {03788741}, journal = {Journal of Ethnopharmacology}, month = {October}, posted-at = {2009-10-30 23:12:28}, title = {Panaxatriol saponins extracted from Panax notoginseng induces thioredoxin-1 and prevents 1-methyl-4-phenylpyridinium ion-induced neurotoxicity}, url = {http://dx.doi.org/10.1016/j.jep.2009.10.023}, year = {2009} }

TY - JOUR ID - citeulike:6045345 L3 - citeulike-article-id:6045345 N2 - Thioredoxin-1 has various biologic activities, including the control of redox balance and the inhibition of apoptosis. It has been reported that thioredoxin-1 and its inducers are beneficial for neuroprotection against oxidative stress-associated neural diseases. In this study, we found panaxatriol saponins (PTS) extracted from Panax notoginseng as a new inducer of thioredoxin-1. PTS attenuated 1-methyl-4-phenylpyridinium ion-induced cell death of PC12 cells. These results indicate PTS has a possible potential as a therapeutic agent for neurodegenerative diseases including Parkinson's disease. JF - Journal of Ethnopharmacology SN - 03788741 TI - Panaxatriol saponins extracted from Panax notoginseng induces thioredoxin-1 and prevents 1-methyl-4-phenylpyridinium ion-induced neurotoxicity AU - Luo, Fucheng AU - Wang, Shengdong AU - Li, Kui AU - Nakamura, Hajime AU - Yodoi, Junji AU - Bai, Jie PY - 2009/10/24/ UR - http://dx.doi.org/10.1016/j.jep.2009.10.023 ER -