Appraisal of antinociceptive and anti-inflammatory potential of extract and fractions from the leaves of Torreya grandis Fort Ex. Lindl Export

@article{citeulike:6045348, abstract = {Torreya grandis ( Taxaceae ) was studied for antinociceptive and anti-inflammatory effects. Leaves were extracted with 80\% ethanol at 80 °C for 3 h and fractionated with petroleum ether, chloroform, ethylacetate and n-butanol respectively. The aqueous ethanolic extract (aq.EE), ethylacetate fraction (EaF) and butanol fraction (BtF) at the doses of (100 and 200 mg/kg, i.g.) body weight were used for study. Evaluation of antinociceptive activity was carried out by acetic acid-induced writhing response and formalin-induced paw licking time in the first and second phases of mice. The paw edema induced by formalin and xylene-induced ear edema were used to assess anti-inflammatory activity. It was found that T. grandis extract and fractions at the doses of (100 and 200 mg/kg, i.g.) were significantly attenuated the writhing responses induced by acetic acid and second phase of pain response induced by sub plantar injection of formalin in mice. In addition, these extract and fractions inhibiting the formaldehyde-induced arthritis as well as xylene-induces edema prolifically. From acute oral toxicity studies no mortality was pragmatic even at highest dose (2500 mg/kg, i.g.). Furthermore, our phytochemical studies indicated that the aq. ethanolic extract of leaves contains alkaloids, flavonoids, tannins, terpenoids and saponins. The results provide justification for the folkloric uses of T. grandis in the treatment of analgesic and inflammatory-based diseases across the China.}, author = {Saeed, Muhammad K. and Deng, Yulin and Dai, Rongji and Li, Wei and Yu, Yuhong and Iqbal, Zafar}, citeulike-article-id = {6045348}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.jep.2009.10.024}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0378874109006801}, day = {24}, doi = {10.1016/j.jep.2009.10.024}, issn = {03788741}, journal = {Journal of Ethnopharmacology}, month = {October}, posted-at = {2009-10-30 23:13:01}, title = {Appraisal of antinociceptive and anti-inflammatory potential of extract and fractions from the leaves of Torreya grandis Fort Ex. Lindl}, url = {http://dx.doi.org/10.1016/j.jep.2009.10.024}, year = {2009} }

TY - JOUR ID - citeulike:6045348 L3 - citeulike-article-id:6045348 N2 - Torreya grandis ( Taxaceae ) was studied for antinociceptive and anti-inflammatory effects. Leaves were extracted with 80% ethanol at 80 °C for 3 h and fractionated with petroleum ether, chloroform, ethylacetate and n-butanol respectively. The aqueous ethanolic extract (aq.EE), ethylacetate fraction (EaF) and butanol fraction (BtF) at the doses of (100 and 200 mg/kg, i.g.) body weight were used for study. Evaluation of antinociceptive activity was carried out by acetic acid-induced writhing response and formalin-induced paw licking time in the first and second phases of mice. The paw edema induced by formalin and xylene-induced ear edema were used to assess anti-inflammatory activity. It was found that T. grandis extract and fractions at the doses of (100 and 200 mg/kg, i.g.) were significantly attenuated the writhing responses induced by acetic acid and second phase of pain response induced by sub plantar injection of formalin in mice. In addition, these extract and fractions inhibiting the formaldehyde-induced arthritis as well as xylene-induces edema prolifically. From acute oral toxicity studies no mortality was pragmatic even at highest dose (2500 mg/kg, i.g.). Furthermore, our phytochemical studies indicated that the aq. ethanolic extract of leaves contains alkaloids, flavonoids, tannins, terpenoids and saponins. The results provide justification for the folkloric uses of T. grandis in the treatment of analgesic and inflammatory-based diseases across the China. JF - Journal of Ethnopharmacology SN - 03788741 TI - Appraisal of antinociceptive and anti-inflammatory potential of extract and fractions from the leaves of Torreya grandis Fort Ex. Lindl AU - Saeed, Muhammad AU - Deng, Yulin AU - Dai, Rongji AU - Li, Wei AU - Yu, Yuhong AU - Iqbal, Zafar PY - 2009/10/24/ UR - http://dx.doi.org/10.1016/j.jep.2009.10.024 ER -