Risk factors for acute respiratory distress syndrome during neutropenia recovery in patients with hematologic malignancies Export

@article{citeulike:6069816, abstract = {IntroductionNeutropenia recovery may be associated with deterioration in oxygenation and exacerbation of pre-existing pulmonary disease. However, risk factors for acute respiratory distress syndrome (ARDS) during neutropenia recovery in patients with hematologic malignancies have not been studied.\&\#10;Methods:\&\#10;We studied critically ill patients with hematologic malignancies with the dual objectives of describing patients with ARDS during neutropenia recovery and identifying risk factors for ARDS during neutropenia recovery. A cohort of consecutive neutropenic patients with hematologic malignancies who were admitted to the intensive care unit (ICU) was studied. During a 6-year period, 71 patients recovered from neutropenia, of whom 38 (53.5\%) developed ARDS during recovery.\&\#10;Results:\&\#10;Compared with non-ARDS patients, patients who experienced ARDS during neutropenia recovery were more likely to have pneumonia, be admitted to the ICU for respiratory failure, and receive mechanical ventilator therapy. The in-ICU mortality was significantly different between the two groups (86.8\% versus 51.5\%, respectively, for patients who developed ARDS during neutropenia recovery versus those who did not during neutropenia recovery). In multivariate analysis, only occurrence of pneumonia during the neutropenic episode was associated with a marked increase in the risk of ARDS (odds ratio, 4.76).\&\#10;Conclusions:\&\#10;Patients with hematologic malignancies complicated by pneumonia during neutropenia are at increased risk for ARDS during neutropenia recovery.}, author = {Rhee, Chin K. and Kang, Ji Y. and Kim, Yong H. and Kim, Jin W. and Yoon, Hyung K. and Kim, Seok C. and Kwon, Soon S. and Kim, Young K. and Kim, Kwan H. and Moon, Hwa S. and Park, Sung H. and Kim, Hee J. and Lee, Seok and Song, Jeong S.}, citeulike-article-id = {6069816}, citeulike-linkout-0 = {http://dx.doi.org/10.1186/cc8149}, day = {03}, doi = {10.1186/cc8149}, issn = {1364-8535}, journal = {Critical Care}, month = {November}, pages = {R173+}, posted-at = {2009-11-04 15:56:15}, title = {Risk factors for acute respiratory distress syndrome during neutropenia recovery in patients with hematologic malignancies}, url = {http://dx.doi.org/10.1186/cc8149}, volume = {13}, year = {2009} }

TY - JOUR ID - citeulike:6069816 L3 - citeulike-article-id:6069816 N2 - IntroductionNeutropenia recovery may be associated with deterioration in oxygenation and exacerbation of pre-existing pulmonary disease. However, risk factors for acute respiratory distress syndrome (ARDS) during neutropenia recovery in patients with hematologic malignancies have not been studied.
Methods:
We studied critically ill patients with hematologic malignancies with the dual objectives of describing patients with ARDS during neutropenia recovery and identifying risk factors for ARDS during neutropenia recovery. A cohort of consecutive neutropenic patients with hematologic malignancies who were admitted to the intensive care unit (ICU) was studied. During a 6-year period, 71 patients recovered from neutropenia, of whom 38 (53.5%) developed ARDS during recovery.
Results:
Compared with non-ARDS patients, patients who experienced ARDS during neutropenia recovery were more likely to have pneumonia, be admitted to the ICU for respiratory failure, and receive mechanical ventilator therapy. The in-ICU mortality was significantly different between the two groups (86.8% versus 51.5%, respectively, for patients who developed ARDS during neutropenia recovery versus those who did not during neutropenia recovery). In multivariate analysis, only occurrence of pneumonia during the neutropenic episode was associated with a marked increase in the risk of ARDS (odds ratio, 4.76).
Conclusions:
Patients with hematologic malignancies complicated by pneumonia during neutropenia are at increased risk for ARDS during neutropenia recovery. JF - Critical Care SN - 1364-8535 TI - Risk factors for acute respiratory distress syndrome during neutropenia recovery in patients with hematologic malignancies VL - 13 SP - R173 AU - Rhee, Chin AU - Kang, Ji AU - Kim, Yong AU - Kim, Jin AU - Yoon, Hyung AU - Kim, Seok AU - Kwon, Soon AU - Kim, Young AU - Kim, Kwan AU - Moon, Hwa AU - Park, Sung AU - Kim, Hee AU - Lee, Seok AU - Song, Jeong PY - 2009/11/03/ UR - http://dx.doi.org/10.1186/cc8149 ER -