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Posted 8 times
Science, Vol. 340, No. 6134. (17 May 2013), pp. 814-815, doi:10.1126/science.1231535
by Lucas N. Joppa, Greg McInerny, Richard Harper, et al.Lara Salido, Kenji Takeda, Kenton O'Hara, David Gavaghan, Stephen Emmott
posted to data_reproducibility scientific_research scientific_software
by peterli
on 2013-05-24 08:54:02
along with 9 people and 2 groups
cbniles
dullhunk
fxdm
jkitchin
kokphinchooi
mtv
peccoud
quanpt
u12010
Integrated Natural Resources Modelling and Management (INRMM)
Journal picks
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Science, Vol. 340, No. 6134. (17 May 2013), pp. 787-787, doi:10.1126/science.1240319
posted to no-tag
by jackson
on 2013-05-22 08:08:28
along with 10 people and 1 group
andresallan
applebyb
dullhunk
Floreees
jkitchin
jpsantos
mikel_egana
neils
rossmounce
uttam2707
Journal picks
AbstractThis Editorial coincides with the release of the San Francisco declaration on research Assessment (DORA), the outcome of a gathering of concerned scientists at the December 2012 meeting of the American Society for Cell Biology.* To correct distortions in the evaluation of scientific research, DORA aims to stop the use of the "journal impact factor" in judging an individual scientist's work. The Declaration states that the impact factor must not be used as "a surrogate measure of the quality of individual ... | |
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Posted 5 times
Sci. Aging Knowl. Environ., Vol. 2002, No. 37. (18 September 2002), cp14
posted to free radical theory
by amelialj
on 2013-05-20 15:37:40
along with 5 people
emilybird
imogenharrison
jdoconnell
laurajarvis
miaelmhirst
AbstractThis 1956 paper describes a theory about mechanisms of aging that is based on free radical chemistry: "Aging and the degenerative diseases associated with it are attributed basically to the deleterious side attacks of free radicals on cell constituents and on the connective tissues. The free radicals probably arise largely through reactions involving molecular oxygen catalyzed in the cell by oxidative enzymes and in the connective tissues by traces of metals such as iron, cobalt, and manganese." Copyright (c) The Gerontological ... | |
  ✔ Folk Knowledge as Legal Action: Death Penalty Judgments and the Tenet of Early Release in a Culture of Mistrust and Punitiveness[CiTO]
posted to death penalty
by athinaki
on 2013-05-21 16:28:04
along with 10 people
annapan
erionatzolli
filiw
KALEMO
konstantinoskar
ljustiss
mwyarbro
nancyeuagatsiou
newgiannis
u12012
AbstractThis article traces interconnections between folk knowledge-the everyday, taken-for-granted understandings and beliefs that shape people's perceptions, actions, and reaction to events and situations-and legal action. It examines the consciousness of crime and punishment as that consciousness comes to bear when citizens are given the responsibility for the life or death decision made by jurors in capital cases. It seeks to identify the sources of both general and specific folk knowledge about the release of convicted capital murderers not sentenced to death ... | |
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(22 May 2013)
by Volker Bromm
posted to review star
by joaopaulonogueiracavalcante
on 2013-05-23 15:51:07
along with 5 people and 1 group
didam
gkulkarni
haofang
pierste
zio_tom78
UWC Astro
AbstractUnderstanding the formation of the first stars is one of the frontier topics in modern astrophysics and cosmology. Their emergence signaled the end of the cosmic dark ages, a few hundred million years after the Big Bang, leading to a fundamental transformation of the early Universe through the production of ionizing photons and the initial enrichment with heavy chemical elements. We here review the state of our knowledge, separating the well understood elements of our emerging picture from those where more work is required. Primordial star formation is ... | |
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Posted 4 times
Nature, Vol. advance online publication (15 May 2013), doi:10.1038/nature12223
by Linfeng Wu, Sophie I. Candille, Yoonha Choi, et al.Dan Xie, Lihua Jiang, Jennifer Li-Pook-Than, Hua Tang, Michael Snyder
posted to gene-expression human-genome
by mandr
on 2013-05-24 14:10:41
along with 8 people
arjun_citeulike
dbk
djkt
fishtank
jbhiatt
lp2
pickw
Yanno
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Nature, Vol. advance online publication (19 May 2013), doi:10.1038/nature12172
by Alex K. Shalek, Rahul Satija, Xian Adiconis, et al.Rona S. Gertner, Jellert T. Gaublomme, Raktima Raychowdhury, Schragi Schwartz, Nir Yosef, Christine Malboeuf, Diana Lu, John T. Trombetta, Dave Gennert, Andreas Gnirke, Alon Goren, Nir Hacohen, Joshua Z. Levin, Hongkun Park, Aviv Regev
posted to no-tag
by siarheimanakov
on 2013-05-23 20:15:03
along with 3 people
cantalapiedra
neils
pedrobeltrao
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(21 May 2013)
posted to feedback modelling
by viogp
on 2013-05-24 11:25:04
along with 3 people
Freeke
gkulkarni
joaopaulonogueiracavalcante
AbstractWe present a multi-epoch analysis of the galaxy populations formed within the cosmological hydrodynamical simulations presented in Vogelsberger et al. (2013). These simulations explore the performance of a recently implemented feedback model which includes primordial and metal line radiative cooling with self-shielding corrections; stellar evolution with associated mass loss and chemical enrichment; feedback by stellar winds; black hole seeding, growth and merging; and AGN quasar- and radio-mode heating with a phenomenological prescription for AGN electro-magnetic feedback. We illustrate the impact of the model parameter choices on the resulting simulated ... | |
✔ Influence of Mass Media on Body Image and Eating Disordered Attitudes and Behaviors in Females: A Review of Effects and Processes[CiTO]Media Psychology, Vol. 13, No. 4. (2010), pp. 387-416, doi:10.1080/15213269.2010.525737
posted to and females mass media
by kazitoriterezaagioub
on 2013-05-21 16:25:07
along with 6 people
antonismantzavinos
eirini94
hthrperkins
LACannon
MariaAlex
Stavrosunipi
AbstractThis article reviews research on the effects of television and magazines on body image and on disordered eating attitudes and behaviors in females. Evidence from different types of studies in the fields of eating disorders, media psychology, health psychology, and mass communication indicates that mass media are an extremely important source of information and reinforcement in relation to the nature of the thin beauty ideal, its importance, and how to attain it. Although considerable research remains to be done, evidence is ... | |
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Nat Rev Genet, Vol. 14, No. 6. (09 June 2013), pp. 379-389, doi:10.1038/nrg3472
posted to gwas review snp
by arjun_citeulike
on 2013-05-21 17:57:52
along with 3 people and 1 group
jbhiatt
qayub
TRHvidsten
Journal picks
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Posted 3 times
(17 May 2013)
AbstractLOFT, the Large Observatory for X-ray Timing, is a new space mission concept devoted to observations of Galactic and extra-Galactic sources in the X-ray domain with the main goals of probing gravity theory in the very strong field environment of black holes and other compact objects, and investigating the state of matter at supra-nuclear densities in neutron stars. The instruments on-board LOFT, the Large area detector and the Wide Field Monitor combine for the first time an unprecedented large effective area (~10 m2 at 8 keV) sensitive to ... | |
✔ The rapid assembly of an elliptical galaxy of 400 billion solar masses at a redshift of 2.3[CiTO]Nature (21 May 2013), doi:10.1038/nature12184
by Hai Fu, Asantha Cooray, C. Feruglio, et al.R. J. Ivison, D. A. Riechers, M. Gurwell, R. S. Bussmann, A. I. Harris, B. Altieri, H. Aussel, A. J. Baker, J. Bock, M. Boylan-Kolchin, C. Bridge, J. A. Calanog, C. M. Casey, A. Cava, S. C. Chapman, D. L. Clements, A. Conley, P. Cox, D. Farrah, D. Frayer, R. Hopwood, J. Jia, G. Magdis, G. Marsden, P. Martinez-Navajas, M. Negrello, R. Neri, S. J. Oliver, A. Omont, M. J. Page, I. Perez-Fournon, B. Schulz, D. Scott, A. Smith, M. Vaccari, I. Valtchanov, J. D. Vieira, M. Viero, L. Wang, J. L. Wardlow, M. Zemcov
AbstractStellar archeology shows that massive elliptical galaxies today formed rapidly about ten billion years ago with star formation rates above several hundreds solar masses per year (M_sun/yr). Their progenitors are likely the sub-millimeter-bright galaxies (SMGs) at redshifts (z) greater than 2. While SMGs' mean molecular gas mass of 5x10^10 M_sun can explain the formation of typical elliptical galaxies, it is inadequate to form ellipticals that already have stellar masses above 2x10^11 M_sun at z ~ 2. Here we report multi-wavelength high-resolution observations of a rare merger of two ... | |
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(21 May 2013)
AbstractWe use a radiation hydrodynamic simulation that models the growth of galaxies and the extragalactic ultraviolet ionizing background (EUVB) self-consistently to study the sources of OI absorption during the hydrogen reionization epoch. Diffuse regions in the intergalactic medium (IGM) are reionized before they are enriched, hence OI absorption is closely associated with dark matter haloes. At z=10, all haloes above the hydrogen cooling limit produce visible absorption out to a substantial fraction of the virial radius. As reionization proceeds, the nascent EUVB ionizes and removes gas from low-mass ... | |
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Pediatrics, Vol. 127, No. 4. (1 April 2011), pp. 800-804, doi:10.1542/peds.2011-0054
posted to media social
by eirini94
on 2013-05-20 18:55:03
along with 11 people
fehlmabarbar
Fneesen
fuzbug
hdz
joannewhite
KBrouwers
MariaAlex
ro-annpasc
Stavrosunipi
SunflowerMelanie11
u12081
AbstractUsing social media Web sites is among the most common activity of today's children and adolescents. Any Web site that allows social interaction is considered a social media site, including social networking sites such as Facebook, MySpace, and Twitter; gaming sites and virtual worlds such as Club Penguin, Second Life, and the Sims; video sites such as YouTube; and blogs. Such sites offer today's youth a portal for entertainment and communication and have grown exponentially in recent years. For this reason, ... | |
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(21 May 2013)
AbstractIt is a paradigm to capture the spread of information and disease with random flow on networks. However, this conventional approach ignores an important feature of the dynamics: where flow moves to depends on where it comes from. That is, memory matters. We analyze multi-step pathways from different systems and show that ignoring memory has profound consequences for community detection and ranking as well as for epidemic spreading. Specifically, memoryless dynamics on networks understate the effect of communities and exaggerate the effect of highly connected nodes. Including memory ... | |
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(19 May 2013)
AbstractWe examine the variability of the high-ionization Lyα λ 1216 broad emission line (BEL) in a sample of 61 high-luminosity, high-redshift quasars observed at two epochs by the Sloan Digital Sky Survey (SDSS). These bright objects lie in the redshift interval z = [2.5, 4.3] and have luminosities greater than λ L~2.7x10^45erg/s at 1300A. Utilizing improved spectrophotometric flux calibrations relative to nearby compact stars observed simultaneously, we are able to measure the flux changes in Lyα and the nearby continuum at two epochs. We find 20 objects that ... | |
✔ A statistical relation between the X-ray spectral index and Eddington ratio of active galactic nuclei in deep surveys[CiTO](16 May 2013)
by M. Brightman, J. D. Silverman, V. Mainieri, et al.Y. Ueda, M. Schramm, K. Matsuoka, T. Nagao, C. Steinhardt, J. Kartaltepe, D. B. Sanders, E. Treister, O. Shemmer, W. N. Brandt, M. Brusa, A. Comastri, L. C. Ho, G. Lanzuisi, E. Lusso, K. Nandra, M. Salvato, G. Zamorani, M. Akiyama, D. M. Alexander, A. Bongiorno, P. Capak, F. Civano, A. Del Moro, A. Doi, M. Elvis, G. Hasinger, E. S. Laird, D. Masters, M. Mignoli, K. Ohta, K. Schawinski, Y. Taniguchi
AbstractWe present an investigation into how well the properties of the accretion flow onto a supermassive black hole may be coupled to those of the overlying hot corona. To do so, we specifically measure the characteristic spectral index, Gamma, of a power-law energy distribution, over an energy range of 2 to 10 keV, for X-ray selected, broad-lined radio-quiet AGN up to z~2 in COSMOS and E-CDF-S. We test the previously reported dependence between Gamma and black hole mass, FWHM and Eddington ratio using a sample of AGN ... | |
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Nature, Vol. advance online publication (12 May 2013), doi:10.1038/nature12132
by Enrique Ibarra-Laclette, Eric Lyons, Gustavo Hernandez-Guzman, et al.Claudia A. Perez-Torres, Lorenzo Carretero-Paulet, Tien-Hao Chang, Tianying Lan, Andreanna J. Welch, Maria J. Juarez, June Simpson, Araceli Fernandez-Cortes, Mario Arteaga-Vazquez, Elsa Gongora-Castillo, Gustavo Acevedo-Hernandez, Stephan C. Schuster, Heinz Himmelbauer, Andre E. Minoche, Sen Xu, Michael Lynch, Araceli Oropeza-Aburto, Sergio A. Cervantes-Perez, Maria de Jesus Ortega-Estrada, Jacob I. Cervantes-Luevano, Todd P. Michael, Todd Mockler, Douglas Bryant, Alfredo Herrera-Estrella, Victor A. Albert, Luis Herrera-Estrella
posted to genome_size plant_genomes
by dandaman
on 2013-05-22 09:58:43
along with 10 people and 1 group
dullhunk
farhat
isaacturner
joeharper
mh19
mikel_egana
mrvaidya
neils
TRHvidsten
wieceka1
Journal picks
AbstractIt has been argued that the evolution of plant genome size is principally unidirectional and increasing owing to the varied action of whole-genome duplications (WGDs) and mobile element proliferation. However, extreme genome size reductions have been reported in the angiosperm family tree. Here we report the sequence of the 82-megabase genome of the carnivorous bladderwort plant Utricularia gibba. Despite its tiny size, the U. gibba ... | |
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(17 May 2013)
by C. Leipski, K. Meisenheimer, F. Walter, et al.M. A. Besel, H. Dannerbauer, X. Fan, M. Haas, U. Klaas, O. Krause, H. W. Rix
AbstractWe present Herschel far-infrared (FIR) photometry of eleven quasars at redshift z>5 that have previously been detected at 1.2mm. We perform full spectral energy distribution (SED) fits over the wavelength range lambda_rest ~0.1-400mu for those objects with good Herschel detections. These fits reveal the need for an additional far-infrared (FIR) component besides the emission from a dusty AGN-powered torus. This additional FIR component has temperatures of T_FIR ~ 40-60K with luminosities of L_(8-1000mu) ~ 10^13 L_sun (accounting for 25-60% of the bolometric FIR luminosity). If the FIR dust ... | |
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(19 May 2013)
posted to information-diffusion popularity preprint self_organized_criticality
by davidecellai
on 2013-05-24 12:46:53
along with 2 people
mkarsai
tavs
AbstractHeavy-tailed distributions of meme popularity occur naturally in a model of meme diffusion on social networks. Competition between multiple memes for the limited resource of user attention is identified as the mechanism that poises the system at criticality. The popularity growth of each meme is described by a critical branching process, and asymptotic analysis predicts power-law distributions of popularity with very heavy tails (exponent $α<2$, unlike preferential-attachment models), similar to those seen in empirical data. ... | |
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(20 May 2013)
AbstractWe define a Maximum Likelihood (ML for short) estimator for the correlation function, ξ, that uses the same pair counting observables (D, R, DD, DR, RR) as the standard Landy and Szalay (1993, LS for short) estimator. The ML estimator outperforms the LS estimator in that it results in smaller measurement errors at any fixed random point density. Put another way, the ML estimator can reach the same precision as the LS estimator with a significantly smaller random point catalog. Moreover, these gains are achieved without significantly increasing ... | |
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(21 May 2013)
AbstractWe develop a analytical approach to the susceptible-infected-susceptible epidemic model that allows us to unravel the true origin of the absence of an epidemic threshold in heterogeneous networks. We find that a delicate balance between the number of high degree nodes in the network and the topological distance between them dictates the existence or absence of such a threshold. In particular, small-world random networks with a degree distribution decaying slower than an exponential have a vanishing epidemic threshold in the thermodynamic limit. ... | |
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Nucleic Acids Research (10 May 2013), doi:10.1093/nar/gkt386
posted to gene-expression networks
by lennyheath
on 2013-05-23 14:30:56
along with 2 people
fuadgwadry
nailest
AbstractGraphite web is a novel web tool for pathway analyses and network visualization for gene expression data of both microarray and RNA-seq experiments. Several pathway analyses have been proposed either in the univariate or in the global and multivariate context to tackle the complexity and the interpretation of expression results. These methods can be further divided into ‘topological’ and ‘non-topological’ methods according to their ability to gain power from pathway topology. Biological pathways are, in fact, not only gene lists but ... | |
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Posted 2 times
(21 May 2013)
AbstractThe NIR is less influenced by dust extinction than optical light. This enables us to look to an extent through dusty regions. In addition, it is sensitive to the mass-dominating stellar population. The combination of NIR imaging and spectroscopy of the VLT integral field spectrograph SINFONI gives us the opportunity to analyze several emission and absorption lines and to investigate the stellar population and ionization mechanisms over a field of view (FOV) of 4x4 square arcsec. We detect several emission lines ([Si VI], Paα, Brγ, H_2, [Fe II]) ... | |
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Diabetes, Vol. 56, No. 7. (July 2007), pp. 1761-1772, doi:10.2337/db06-1491
by Patrice D. Cani, Jacques Amar, Miguel Angel A. Iglesias, et al.Marjorie Poggi, Claude Knauf, Delphine Bastelica, Audrey M. Neyrinck, Francesca Fava, Kieran M. Tuohy, Chantal Chabo, Aurélie Waget, Evelyne Delmée, Béatrice Cousin, Thierry Sulpice, Bernard Chamontin, Jean Ferrières, Jean-François F. Tanti, Glenn R. Gibson, Louis Casteilla, Nathalie M. Delzenne, Marie Christine C. Alessi, Rémy Burcelin
posted to bachelor trials
by u12010
on 2013-05-19 11:08:58
along with 3 people and 6 groups
arthurkoestler
ftv88
HEIRS
HEIRS - Environmental Illness Research
HEIRS Bacteriology
HEIRS Cellular Biology
HEIRS Diabetes, Insulin Resistance and Metabolic Syndrome Research
HEIRS Immunology and Autoimmune Diseases
HEIRS Obesity and Lipid Regulation
AbstractDiabetes and obesity are two metabolic diseases characterized by insulin resistance and a low-grade inflammation. Seeking an inflammatory factor causative of the onset of insulin resistance, obesity, and diabetes, we have identified bacterial lipopolysaccharide (LPS) as a triggering factor. We found that normal endotoxemia increased or decreased during the fed or fasted state, respectively, on a nutritional basis and that a 4-week high-fat diet chronically ... | |
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The Journal of Neuroscience, Vol. 33, No. 21. (22 May 2013), pp. 9194-9201, doi:10.1523/jneurosci.5902-12.2013
posted to audiovisual auditory multi_modal
by ybysk
on 2013-05-22 21:02:25
along with 1 person and 1 group
shivakmr
UAB Human Behavioral Neuroscience
AbstractSudden changes in the acoustic environment enhance perceptual processing of subsequent visual stimuli that appear in close spatial proximity. Little is known, however, about the neural mechanisms by which salient sounds affect visual processing. In particular, it is unclear whether such sounds automatically activate visual cortex. To shed light on this issue, this study examined event-related brain potentials (ERPs) that were triggered either by peripheral sounds that preceded task-relevant visual targets (Experiment 1) or were presented during purely auditory tasks (Experiments ... | |
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(21 May 2013)
AbstractWe describe a long-term Swift monitoring program of Fermi gamma-ray sources, particularly the 23 gamma-ray "sources of interest." We present a systematic analysis of the Swift X-ray Telescope light curves and hardness ratios of these sources, and we calculate excess variability. We present data for the time interval of 2004 December 22 through 2012 August 31. We describe the analysis methods used to produce these data products, and we discuss the availability of these data in an online repository, which continues to grow from more data on these ... | |
✔ Cross-Species Protein Interactome Mapping Reveals Species-Specific Wiring of Stress Response Pathways[CiTO]Sci. Signal., Vol. 6, No. 276. (21 May 2013), ra38, doi:10.1126/scisignal.2003350
by Jishnu Das, Tommy V. Vo, Xiaomu Wei, et al.Joseph C. Mellor, Virginia Tong, Andrew G. Degatano, Xiujuan Wang, Lihua Wang, Nicolas A. Cordero, Nathan Kruer-Zerhusen, Akihisa Matsuyama, Jeffrey A. Pleiss, Steven M. Lipkin, Minoru Yoshida, Frederick P. Roth, Haiyuan Yu
posted to evolution protein_interactions stress_response yeast
by jjray
on 2013-05-22 21:17:41
along with 1 person
arjun_citeulike
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Nature, Vol. advance online publication (22 May 2013), doi:10.1038/nature12211
by Björn Nystedt, Nathaniel R. Street, Anna Wetterbom, et al.Andrea Zuccolo, Yao-Cheng Lin, Douglas G. Scofield, Francesco Vezzi, Nicolas Delhomme, Stefania Giacomello, Andrey Alexeyenko, Riccardo Vicedomini, Kristoffer Sahlin, Ellen Sherwood, Malin Elfstrand, Lydia Gramzow, Kristina Holmberg, Jimmie Hällman, Olivier Keech, Lisa Klasson, Maxim Koriabine, Melis Kucukoglu, Max Käller, Johannes Luthman, Fredrik Lysholm, Totte Niittylä, Åke Olson, Nemanja Rilakovic, Carol Ritland, Josep A. Rosselló, Juliana Sena, Thomas Svensson, Carlos Talavera-López, Günter Theißen, Hannele Tuominen, Kevin Vanneste, Zhi-Qiang Wu, Bo Zhang, Philipp Zerbe, Lars Arvestad, Rishikesh Bhalerao, Joerg Bohlmann, Jean Bousquet, Rosario Garcia Gil, Torgeir R. Hvidsten, Pieter de Jong, John MacKay, Michele Morgante, Kermit Ritland, Björn Sundberg, Stacey Lee Thompson, Yves Van de Peer, Björn Andersson, Ove Nilsson, Pär K. Ingvarsson, Joakim Lundeberg, Stefan Jansson
posted to conifer evolution genome sequence spruce tree
by neils
on 2013-05-22 22:27:06
along with 1 person
natstreet
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✔ Efficient authentication scheme for data aggregation in smart grid with fault tolerance and fault diagnosis[CiTO]In 2012 IEEE PES Innovative Smart Grid Technologies (ISGT) (January 2012), pp. 1-8, doi:10.1109/isgt.2012.6175680
posted to methods
by galaxyproject
to the group Galaxy
on 2013-05-23 19:08:05
along with 1 person
zeyarag
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✔ How many quantum phase transitions exist inside the superconducting dome of the iron pnictides?[CiTO](20 May 2013)
posted to pnictides superconductors
by janpaniev
on 2013-05-22 15:01:15
along with 1 person
lenibascones
AbstractRecent experiments on two iron-pnictide families suggest the existence of a single quantum phase transition (QPT) inside the superconducting dome despite the fact that two separate transition lines - magnetic and nematic - cross the superconducting dome at $T_c$. Here we argue that these two observations are actually consistent. We show, using a microscopic model, that each order coexists with superconductivity for a wide range of parameters, and both transition lines continue into the superconducting dome below $T_c$. However, at some $T_\mathrmmerge<T_c$, the two transitions merge and continue ... | |
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American Journal of Physics, Vol. 81, No. 6. (21 May 2013), 414, doi:10.1119/1.4798490
posted to cosmology review software
by zio_tom78
on 2013-05-22 11:39:15
along with 2 people
Celsior
pvmoniz
AbstractWe present a collection of new, open-source computational tools for numerically modeling recent large-scale observational data sets using modern cosmology theory. Specifically, these tools will allow both students and researchers to constrain the parameter values in competitive cosmological models, thereby discovering both the accelerated expansion of the universe and its composition (e.g., dark matter and dark energy). These programs have several features to help the non-cosmologist build an understanding of cosmological models and their relation to observational data: a built-in collection of several real observational data sets; sliders to ... | |
✔ The reduction of intoxication and disorder in premises licensed to serve alcohol: An exploratory randomised controlled trial[CiTO]BMC Public Health, Vol. 10, No. 1. (14 October 2010), 607, doi:10.1186/1471-2458-10-607
by Simon Moore, Iain Brennan, Simon Murphy, et al.Ellie Byrne, Susan Moore, Jonathan Shepherd, Laurence Moore
AbstractBACKGROUND:Licensed premises offer a valuable point of intervention to reduce alcohol-related harm.OBJECTIVE:To describe the research design for an exploratory trial examining the feasibility and acceptability of a premises-level intervention designed to reduce severe intoxication and related disorder. The study also aims to assess the feasibility of a potential future large scale effectiveness trial and provide information on key trial design parameters including inclusion criteria, premises recruitment methods, strategies to implement the intervention and trial design, outcome measures, data collection methods and ... | |
✔ Bending Free Energy from Simulation: Correspondence of Planar and Inverse Hexagonal Lipid Phases[CiTO]Biophys J, Vol. 104, No. 10. (21 May 2013), pp. 2202-2211, doi:10.1016/j.bpj.2013.03.048
posted to lipid-curvature membrane-structure
by agrossfield
on 2013-05-22 13:39:19
along with 1 person
paulschlesinger
AbstractSimulations of two distinct systems, one a planar bilayer, the other the inverse hexagonal phase, indicate consistent mechanical properties and curvature preferences, with single DOPE leaflets having a spontaneous curvature, R0 = 26 Å (experimentally <29.2 Å) and DOPC leaflets preferring to be approximately flat (R0= 65 Å, experimentally <87.3 Å). Additionally, a well-defined pivotal plane, where a DOPE leaflet bends at constant area, has been determined to be near the glycerol region of the lipid, consistent with the experimentally predicted plane. By examining the curvature ... | |
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Intelligence (May 2013), doi:10.1016/j.intell.2013.04.001
by David Z. Hambrick, Frederick L. Oswald, Erik M. Altmann, Elizabeth J. Meinz, Fernand Gobet, Guillermo Campitelli
posted to cognition cognitive_development cognitive_training expertise learning skill_acquisition
by flieder
on 2013-05-23 10:14:31
along with 1 person
hukkinen
AbstractEricsson and colleagues argue that deliberate practice explains expert performance. We tested this view in the two most studied domains in expertise research. Deliberate practice is not sufficient to explain expert performance. Other factors must be considered to advance the science of expertise. Twenty years ago, Ericsson, Krampe, and Tesch-Römer (1993) proposed that expert performance reflects a long period of deliberate practice rather than innate ability, or “talent”. Ericsson et al. found that elite musicians had accumulated thousands of hours ... | |
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(17 May 2013)
AbstractWe transpose the theory of rank metric and Gabidulin codes to the case of fields of characteristic zero. The Frobenius automorphism is then replaced by any element of the Galois group. We derive some conditions on the automorphism to be able to easily transpose the results obtained by Gabidulin as well and a classical polynomial-time decoding algorithm. We also provide various definitions for the rank-metric. ... | |
✔ Gene Expression Classification of Colon Cancer into Molecular Subtypes: Characterization, Validation, and Prognostic Value[CiTO]PLoS Med, Vol. 10, No. 5. (21 May 2013), e1001453, doi:10.1371/journal.pmed.1001453
by Laetitia Marisa, Aurélien de Reyniès, Alex Duval, et al.Janick Selves, Marie P. Gaub, Laure Vescovo, Marie-Christine Etienne-Grimaldi, Renaud Schiappa, Dominique Guenot, Mira Ayadi, Sylvain Kirzin, Maurice Chazal, Jean-François Fléjou, Daniel Benchimol, Anne Berger, Arnaud Lagarde, Erwan Pencreach, Françoise Piard, Dominique Elias, Yann Parc, Sylviane Olschwang, Gérard Milano, Pierre Laurent-Puig, Valérie Boige
posted to cancer classification colorectal expression prognosis tcga
by neils
on 2013-05-23 00:39:33
along with 1 person
michellesabrina
AbstractColon cancer (CC) pathological staging fails to accurately predict recurrence, and to date, no gene expression signature has proven reliable for prognosis stratification in clinical practice, perhaps because CC is a heterogeneous disease. The aim of this study was to establish a comprehensive molecular classification of CC based on mRNA expression profile analyses. Fresh-frozen primary tumor samples from a large multicenter cohort of 750 patients with stage I to IV CC who underwent surgery between 1987 and 2007 in seven centers ... | |
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Bioinformatics (Oxford, England) (15 May 2013), doi:10.1093/bioinformatics/btt277
posted to alignment next-generation-sequencing tandem-repeat
by youngl
on 2013-05-24 06:52:10
along with 1 person
fuadgwadry
AbstractMOTIVATION: Simple tandem repeats are highly variable genetic elements and widespread in genomes of many organisms. Next-generation sequencing technologies have enabled a robust comparison of large numbers of simple tandem repeat loci, however analysis of their variation using traditional sequence analysis approaches still remains limiting and problematic due to variants occurring in repeat sequences confusing alignment programs into mapping sequence reads to incorrect loci when ... | |
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(20 May 2013)
posted to bubbles dark-matter fermi gamma-rays
by bbaugh
on 2013-05-21 12:48:09
along with 1 person
ksj7924
AbstractThe Fermi Gamma-ray Space Telescope discovered two γ-ray emitting bubble-shaped structures that extend nearly symmetrically on either side of our Galaxy and appear morphologically connected to the Galactic Center. The origin of the emission is still not clearly understood. It was recently shown that the spectral shape of the emission from the Fermi Bubbles is well described by an approximately 10 GeV dark matter particle annihilating to τ^+ τ^-, with a normalization corresponding to a velocity average annihilation cross section of \langle σ v \rangle ∼ 2 × ... | |
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Nature, Vol. advance online publication (15 May 2013), doi:10.1038/nature12148
posted to computational method nature synthetic tlu
by jbhiatt
on 2013-05-19 01:51:44
along with 4 people
Borelli
gstan
pablocarb
tellis
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Proceedings of the National Academy of Sciences (20 May 2013), doi:10.1073/pnas.1219099110
by Konrad J. Karczewski, Joel T. Dudley, Kimberly R. Kukurba, et al.Rong Chen, Atul J. Butte, Stephen B. Montgomery, Michael Snyder
AbstractGenome-wide association studies have discovered many genetic loci associated with disease traits, but the functional molecular basis of these associations is often unresolved. Genome-wide regulatory and gene expression profiles measured across individuals and diseases reflect downstream effects of genetic variation and may allow for functional assessment of disease-associated loci. Here, we present a unique approach for systematic integration of genetic disease associations, transcription factor binding among individuals, and gene expression data to assess the functional consequences of variants associated with hundreds ... | |
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(18 May 2013)
AbstractWe report on the development of a test-particle based kinetic Monte Carlo code for large systems and its application to simulate matter in the continuum regime. Our code combines advantages of the Direct Simulation Monte Carlo and the Point-of-Closest-Approach methods to solve the collision integral of the Boltzmann equation. With that, we achieve a high spatial accuracy in simulations while maintaining computational feasibility when applying a large number of test-particles. The hybrid setup of our approach allows us to study systems which move in and out of the ... | |
✔ Data mining in the Life Sciences with Random Forest: a walk in the park or lost in the jungle?[CiTO]Briefings in Bioinformatics, Vol. 14, No. 3. (1 May 2013), pp. 315-326, doi:10.1093/bib/bbs034
by Wouter G. Touw, Jumamurat R. Bayjanov, Lex Overmars, et al.Lennart Backus, Jos Boekhorst, Michiel Wels, Sacha A. F. T. van Hijum
posted to data-mining random-forest review statistics
by neils
on 2013-05-21 22:33:48
along with 8 people and 3 groups
arjun_citeulike
cisevol
druvus
dullhunk
lmichan
nickholway
richrr
synthaxerror
BergmanLab
Biiiogeek
Journal picks
AbstractIn the Life Sciences ‘omics’ data is increasingly generated by different high-throughput technologies. Often only the integration of these data allows uncovering biological insights that can be experimentally validated or mechanistically modelled, i.e. sophisticated computational approaches are required to extract the complex non-linear trends present in omics data. Classification techniques allow training a model based on variables (e.g. SNPs in genetic association studies) to separate different classes (e.g. healthy subjects versus patients). Random Forest (RF) is a versatile classification algorithm suited ... | |
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Nature Geosci, Vol. advance online publication (19 May 2013), doi:10.1038/ngeo1836
by Alexander Otto, Friederike E. L. Otto, Olivier Boucher, et al.John Church, Gabi Hegerl, Piers M. Forster, Nathan P. Gillett, Jonathan Gregory, Gregory C. Johnson, Reto Knutti, Nicholas Lewis, Ulrike Lohmann, Jochem Marotzke, Gunnar Myhre, Drew Shindell, Bjorn Stevens, Myles R. Allen
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✔ On validity and controls in animal personality research: a comment on Galhardo et al. (2012)[CiTO]Biology Letters, Vol. 9, No. 4. (23 August 2013), pp. 20121080-20121080, doi:10.1098/rsbl.2012.1080
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Journal of computational biology : a journal of computational molecular cell biology (15 May 2013), 130515065517005, doi:10.1089/cmb.2013.0017
AbstractAbstract Because a very large number of gene expression data sets are currently publicly available, comparisons across experiments between different laboratories have become a common task. However, most existing methods of comparing gene expression data sets require setting arbitrary cutoffs (e.g., for statistical significance or fold change), which could select genes according to different criteria because of differences in experimental protocols and statistical analysis in ... | |
✔ Quantum Interferometric Optical Lithography: Exploiting Entanglement to Beat the Diffraction Limit[CiTO]Physical Review Letters, Vol. 85, No. 13. (25 Sep 2000), pp. 2733-2736, doi:10.1103/physrevlett.85.2733
by Agedi N. Boto, Pieter Kok, Daniel S. Abrams, Samuel L. Braunstein, Colin P. Williams, Jonathan P. Dowling
posted to quantum_lithography
by hongxinghan
on 2013-05-22 16:41:58
along with 3 people
holx
Kricki
Ladril
AbstractClassical optical lithography is diffraction limited to writing features of a size λ/2 or greater, where λ is the optical wavelength. Using nonclassical photon-number states, entangled N at a time, we show that it is possible to write features of minimum size λ/(2N) in an N-photon absorbing substrate. This result allows one to write a factor of N2 more elements on a semiconductor chip. A factor of N = 2 can be achieved easily with entangled photon pairs generated from optical parametric down-conversion. ... | |
✔ Explicit Ligand Hydration Shells Improve the Correlation between MM-PB/GBSA Binding Energies and Experimental Activities[CiTO]J. Chem. Theory Comput. (6 May 2013), doi:10.1021/ct400045d
AbstractMolecular Mechanics Poisson?Boltzmann Surface Area (MM-PBSA) and Molecular Mechanics Generalized Born Surface Area (MM-GBSA) methods are widely used for drug design/discovery purposes. However, it is not clear if the correlation between predicted and experimental binding affinities can be improved by explicitly considering selected water molecules in the calculation of binding energies, since different and sometimes diverging opinions are found in the literature. In this work, we evaluated how variably populated hydration shells explicitly considered around the ligands may affect the correlation ... | |
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Proceedings of the National Academy of Sciences, Vol. 110, No. 21. (21 May 2013), pp. 8337-8344, doi:10.1073/pnas.1305393110
posted to binocular perception psychophysics
by iandol
on 2013-05-23 14:54:32
along with 1 person
PaperCollector
AbstractWhen corresponding areas of the two eyes view dissimilar images, stable perception gives way to visual competition wherein perceptual awareness alternates between those images. Moreover, a given image can remain visually dominant for several seconds at a time even when the competing images are swapped between the eyes multiple times each second. This perceptual stability across eye swaps has led to the widespread belief that this unique form of visual competition, dubbed stimulus rivalry, is governed by eye-independent neural processes at ... | |
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Biology Letters, Vol. 8, No. 6. (23 December 2012), pp. 936-938, doi:10.1098/rsbl.2012.0500
posted to cichlid cortisol fish hormone personality social_context
by Benetnuts
on 2013-05-22 05:57:22
along with 2 people
fxdm
st3vil
AbstractPersonality traits, such as exploration–avoidance, are expected to be adaptive in a given context (e.g. low-risk environment) but to be maladaptive in others (e.g. high-risk environment). Therefore, it is expected that personality traits are flexible and respond to environmental fluctuations, given that consistency across different contexts is maintained, so that the relative individual responses in relation to others remains the same (i.e. although the magnitude of the response varies the differences between high and low responders are kept). Here, we tested ... | |
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Briefings in Bioinformatics, Vol. 14, No. 3. (1 May 2013), pp. 263-278, doi:10.1093/bib/bbs028
posted to microrna-targets
by richrr
on 2013-05-21 17:05:42
along with 6 people
briangodsey
druvus
jfr
kshameer
misonneh
rpiro
AbstractmiRNAs are small RNA molecules (′22 nt) that interact with their target mRNAs inhibiting translation or/and cleavaging the target mRNA. This interaction is guided by sequence complentarity and results in the reduction of mRNA and/or protein levels. miRNAs are involved in key biological processes and different diseases. Therefore, deciphering miRNA targets is crucial for diagnostics and therapeutics. However, miRNA regulatory mechanisms are complex and there is still no high-throughput and low-cost miRNA target screening technique. In recent years, several computational methods based ... | |
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British Journal of Educational Technology, Vol. 35, No. 6. (2004), pp. 689-700, doi:10.1111/j.1467-8535.2004.00427.x
posted to csu eportfolios learning lifelong ncepr network technologies
by konstantinoskar
on 2013-05-20 20:21:31
along with 5 people and 1 group
athinaki
magnusenger
MariaAlex
quekelly0
rickl
OpenArchive
AbstractAbstract The requirements placed on learning technologies to support lifelong learning differ considerably from those placed on technologies to support particular fragments of a learning lifetime. The time scales involved in lifelong learning, together with its multi-institutional and episodic nature are not reflected in today's mainstream learning technologies and their associated architectures. The article presents an integrated model and architecture to serve as the basis for the realisation of networked learning technologies serving the specific needs and characteristics of lifelong learners. ... | |
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International Journal of Automotive Technology In International Journal of Automotive Technology, Vol. 10, No. 5. (1 October 2009), pp. 607-610, doi:10.1007/s12239-009-0071-8
AbstractThis paper puts forward a method of preliminary driver classification, which applies two-criteria based analysis of the phenomenon of driving style. The resulting rank enabled the author to order the drivers according to their driving style, from the most active to the extremely mild. The most active driver in the sense of the two-criteria analysis is the one who covered a test stretch of the road the fastest while changing the position of the accelerator pedal most intensively. The classification of ... | |
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(21 May 2013)
by Florian Pranger, Asmus Böhm, Chiara Ferrari, et al.Antonaldo Diaferio, Richard Hunstead, Sophie Maurogordato, Christophe Benoist, Jarle Brinchmann, Sabine Schindler
AbstractWe present a spectrophotometric analysis of the galaxy pop. in the area of the merging cluster Abell 3921 at redshift 0.093. We investigate the impact of the complex cluster environment on galaxy properties such as morphology or star formation rate. We combine multi-object spectroscopy from the 2dF spectrograph with optical imaging taken with the ESO WFI. We carry out a redshift analysis and determine cluster velocity dispersions using biweight statistics. Applying a Dressler-Shectman (DS-)test we seek evidence for cluster substructure. Cluster and field galaxies are investigated with respect ... | |
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Vision research, Vol. 39, No. 11. (June 1999), pp. 1963-1989
by R. P. Rao
AbstractHow does the visual system learn an internal model of the external environment? How is this internal model used during visual perception? How are occlusions and background clutter so effortlessly discounted for when recognizing a familiar object? How is a particular object of interest attended to and recognized in the presence of other objects in the field of view? In this paper, we attempt to ... | |
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Science, Vol. 308, No. 5721. (22 April 2005), pp. 523-529, doi:10.1126/science.1105809
posted to bayesian-networks causality systems-biology
by srirampc
on 2013-05-23 14:17:57
along with 39 people and 1 group
abhishek_tiwari
aviad_work
balajis
cdppublications
colmryan
czeller
emptyhb
engelhardt
frohike
gogodidi
Gralha
heathervincent
j3xucite
jhatrimatri
jtcribbs
kaarsinogen
kangism
kentsis
koller
kshameer
lflorez
lp2
noano
os252
phoenixzxl
pkm
pmcmullen
poirel
porejide
psebastian
qluo
rand_bayes
roys
ryang
saman_vp
sameersoi
vingron
wnpx
Yanno
CDP
AbstractMachine learning was applied for the automated derivation of causal influences in cellular signaling networks. This derivation relied on the simultaneous measurement of multiple phosphorylated protein and phospholipid components in thousands of individual primary human immune system cells. Perturbing these cells with molecular interventions drove the ordering of connections between pathway components, wherein Bayesian network computational methods automatically elucidated most of the traditionally reported signaling relationships and predicted novel interpathway network causalities, which we verified experimentally. Reconstruction of network models from ... | |
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PLoS Genet, Vol. 9, No. 2. (7 February 2013), e1003264, doi:10.1371/journal.pgen.1003264
AbstractBoth linear mixed models (LMMs) and sparse regression models are widely used in genetics applications, including, recently, polygenic modeling in genome-wide association studies. These two approaches make very different assumptions, so are expected to perform well in different situations. However, in practice, for a given dataset one typically does not know which assumptions will be more accurate. Motivated by this, we consider a hybrid of the two, which we refer to as a “Bayesian sparse linear mixed model” (BSLMM) that includes ... | |
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Cell, Vol. 144, No. 5. (4 March 2011), pp. 646-674, doi:10.1016/j.cell.2011.02.013
posted to cancer cancer_biology cancer_research
by iskanbasal
on 2013-05-20 17:45:53
along with 36 people
arnulfarnulf
bertelsen
BioNica
Bolozna
Borelli
ccw20
cdr4084
dakelley
drjoey
ealloza
erisen
eyliu
gdb
golharam
ilyashl
isbkramer
kantmoor
kmdaily
koyanagicl
kyoohyoungrho
marti
mikelove
misonneh
nailest
nemisisnik
nicholasflann
nurmustafaoglu
paulschlesinger
pickw
pkurywchak
poirel
PolymeraseI
spongelab
thompsonneildoman
tonamswish
Zephyrus
AbstractThe hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis. Underlying these hallmarks are genome instability, which generates the genetic diversity that expedites their acquisition, and inflammation, which fosters multiple hallmark functions. Conceptual progress in the last decade has added two ... | |
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(17 May 2013)
posted to cox_process expectation_propagation gaussian_process point_process poisson_process spatio_temporal
by dah
on 2013-05-20 15:22:44
along with 1 person and 1 group
elmiller
LaSIR Research Group Papers
AbstractAnalysis of spatio-temporal point patterns plays an important role in several disciplines, yet inference in these systems remains computationally challenging due to the high resolution modelling generally required by large data sets and the analytically intractable likelihood function. Here, we exploit the sparsity structure of a fully-discretised log-Gaussian Cox process model by using expectation constrained approximate inference. The resulting family of expectation propagation algorithms scale well with the state dimension and the length of the temporal horizon with moderate loss in distributional accuracy. They hence provide a flexible and ... | |
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Learning, Media and Technology (8 March 2013), pp. 1-16, doi:10.1080/17439884.2013.777077
posted to education online-social-networks
by ShantanuPal
on 2013-05-24 03:02:05
along with 3 people
AJCann
antonellaesposito
tnhh
AbstractThe Visitors and Residents model of internet use suggests a continuum of modes of engagement with the online world, ranging from tool use to social spaces. In this paper, we examine evidence derived from a large cohort of students to assess whether this idea can be validated by experimental evidence. We find statistically significant differences between individuals displaying ?Visitor? or ?Resident? attitudes, suggesting that the Visitors and Residents model is a useful typology for approaching and understanding online behaviour. From our ... | |
✔ The development of the Game Engagement Questionnaire: A measure of engagement in video game-playing[CiTO]Journal of Experimental Social Psychology, Vol. 45, No. 4. (12 July 2009), pp. 624-634, doi:10.1016/j.jesp.2009.02.016
by Jeanne H. Brockmyer, Christine M. Fox, Kathleen A. Curtiss, Evan McBroom, Kimberly M. Burkhart, Jacquelyn N. Pidruzny
posted to engagement game questionnaire
by bwf
on 2013-05-22 10:45:42
along with 5 people
dwenig
mapto
mjparnell
twtsai
waiyen
AbstractDeep engagement in video game-playing has the potential to be to be one important determinant of the impact of playing violent video games, but there are currently no reliable measures of this subjective experience. To fill this gap, the Game Engagement Questionnaire (GEQ) was developed using both classical and Rasch analyses. In Study 1 Rasch analyses provide support for the reliability and functionality of the GEQ scores. Rasch analyses also demonstrate that the GEQ has adequate separation, fit, rating scale functioning, ... | |
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Nature, Vol. 497, No. 7450. (23 May 2013), pp. 439-439, doi:10.1038/497439a
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Phys. Rev. ST Phys. Educ. Res., Vol. 9 (May 2013), 010120, doi:10.1103/physrevstper.9.010120
posted to problemsolving professionaldevelopment teaching-assistants
by mcwittmann
to the group PERticles
on 2013-05-23 20:50:38
along with 1 person
cassandrapaul
AbstractAs part of a larger study to understand instructorsâ considerations regarding the learning and teaching of problem solving in an introductory physics course, we investigated beliefs of first-year graduate teaching assistants (TAs) regarding the use of example solutions in introductory physics. In particular, we examine how the goal of promoting expertlike problem solving is manifested in the considerations of graduate TAsâ choices of example solutions. Twenty-four first-year graduate TAs were asked to discuss their goals for presenting example solutions to students. ... | |
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In Wireless Networks (2013), pp. 1-21, doi:10.1007/s11276-013-0597-6
posted to cambridge_haggle manet routing unimi_pmtr uses_crawdad_data
by tnhh
to the group CRAWDAD
on 2013-05-22 11:52:49
along with 1 person
ShantanuPal
AbstractWe propose Multi-Spreader Routing, a store-carry-forward routing scheme for sparsely populated mobile ad hoc networks. Multi-Spreader Routing includes Epidemic Routing and Two-Hop Forwarding as special cases, and it can manage trade-off between message delivery delay and resource consumption effectively. We analyze various performance measures of Multi-Spreader Routing with a recovery scheme called VACCINE, and we evaluate its performance. Further, through simulation experiments with real mobility trace data, we demonstrate that Multi-Spreader Routing shows stable performance in various network environments. ... | |
✔ A finite time horizon influences sequential mate choice in male Gammarus aequicauda(Amphipoda)[CiTO]Canadian Journal of Zoology, Vol. 76, No. 3. (March 1998), pp. 400-404, doi:10.1139/z97-211
posted to amphipod assortative_mating crustacean gammarus homogamy moult
by Benetnuts
on 2013-05-22 05:58:55
along with 2 people
fxdm
Wananahass
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✔ A support vector machine for identification of single-nucleotide polymorphisms from next-generation sequencing data[CiTO]Bioinformatics, Vol. 29, No. 11. (1 June 2013), pp. 1361-1366, doi:10.1093/bioinformatics/btt172
posted to ngs snp tool variants
by idonaldson
on 2013-05-23 10:09:37
along with 3 people
nailest
neils
phoenixzxl
AbstractMotivation: Accurate determination of single-nucleotide polymorphisms (SNPs) from next-generation sequencing data is a significant challenge facing bioinformatics researchers. Most current methods use mechanistic models that assume nucleotides aligning to a given reference position are sampled from a binomial distribution. While such methods are sensitive, they are often unable to discriminate errors resulting from misaligned reads, sequencing errors or platform artifacts from true variants.Results: To enable more accurate SNP calling, we developed an algorithm that uses a trained support vector machine (SVM) ... | |
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Clinical journal of sport medicine, Vol. 14, No. 1. (January 2004), pp. 25-32
posted to assignment2 fat hsn709 master_of_human_nutrition
by u12010
on 2013-05-19 10:44:34
along with 1 person
nixe77
AbstractThe objectives of the study were to examine the prevalence of anorexia nervosa (AN), bulimia nervosa (BN), anorexia athletica (AA), and eating disorders not otherwise specified (ED-NOS) in both male and female Norwegian elite athletes and a representative sample from the general Norwegian population. A 2-step study including self-reported questionnaire ... | |
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American Educational Research Journal, Vol. 50, No. 3. (1 June 2013), pp. 574-615, doi:10.3102/0002831213476334
posted to early_career practice teacher teachers transition
by pigironjoe
on 2013-05-19 19:53:49
along with 1 person
mergler
AbstractCurrent theories of novice teacher learning have not accounted for the varied influences of pedagogical training, subject matter knowledge, tools, identity, and institutional context(s) on the development of classroom practice. We examined how 26 beginning secondary science teachers developed instructional repertoires as they participated in two types of communities, one infused with discourses and tools supportive of ambitious teaching and another that reinforced traditional practices. We found three trajectories of practice—each with distinctive signatures for how novices engaged students intellectually. Differences ... | |
✔ The Taverna workflow suite: designing and executing workflows of Web Services on the desktop, web or in the cloud[CiTO]Nucleic Acids Research (2 May 2013), doi:10.1093/nar/gkt328
by Katherine Wolstencroft, Robert Haines, Donal Fellows, et al.Alan Williams, David Withers, Stuart Owen, Stian Soiland-Reyes, Ian Dunlop, Aleksandra Nenadic, Paul Fisher, Jiten Bhagat, Khalid Belhajjame, Finn Bacall, Alex Hardisty, Abraham Nieva de la Hidalga, Maria P. Balcazar Vargas, Shoaib Sufi, Carole Goble
posted to workflow_tools
by cdsouthan
on 2013-05-24 09:09:48
along with 4 people and 2 groups
dullhunk
egonw
galaxyproject
mikel_egana
Galaxy
Journal picks
AbstractThe Taverna workflow tool suite (http://www.taverna.org.uk) is designed to combine distributed Web Services and/or local tools into complex analysis pipelines. These pipelines can be executed on local desktop machines or through larger infrastructure (such as supercomputers, Grids or cloud environments), using the Taverna Server. In bioinformatics, Taverna workflows are typically used in the areas of high-throughput omics analyses (for example, proteomics or transcriptomics), or for evidence gathering methods involving text mining or data mining. Through Taverna, scientists have access to several ... | |
✔ Concepts and practices of education and adult education: obstacles to lifelong education and lifelong learning?[CiTO]International Journal of Lifelong Education, Vol. 18, No. 5. (1999), pp. 343-354, doi:10.1080/026013799293595
by Colin Titmus
posted to education learning lifelong
by panagiotakaska
on 2013-05-21 16:24:17
along with 5 people
amandaalders
dinaz
konstantinoskar
lcastillo
NLHovik
AbstractOver the last half century, in varying degrees and under various names, there has been much interest in learning throughout life for everybody. Although what has been written has stressed its necessity and feasibility, little has been achieved. As is common to all things educational, it has lagged behind the times. Little considered and highly resistant among the obstacles to it are the current concepts, institutions and practices of education. The widespread, systematic study of education in the 19th century grew ... | |
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The New England journal of medicine, Vol. 340, No. 14. (8 April 1999), pp. 1092-1098, doi:10.1056/nejm199904083401407
posted to assignment2 fat hsn709 master_of_human_nutrition
by u12010
on 2013-05-19 11:08:04
along with 1 person
nixe77
AbstractEating disorders are common among adolescent girls and young women and are associated with potentially serious medical complications, yet they often go undetected and untreated. All patients with eating disorders should be evaluated and treated for medical complications of the disease at the same time that psychotherapy and nutritional counseling are undertaken. Pharmacologic agents are often useful as adjuncts to psychotherapy for bulimia nervosa or ... | |
 (31 July 2009)
posted to algorithm discrete_math
by yochju
on 2013-05-24 07:54:47
along with 14 people
anggao
elsantosneto
Fantozzi
fruehrentner
jaimecohen
jimburton
marciofsoliveira
mertnuhoglu
mmeteo
n00c
rrufai
s-t-ahi
UsmanNMKhan
waldyd
AbstractAimed at any serious programmer or computer science student, the new second edition of _Introduction to Algorithms_ builds on the tradition of the original with a truly magisterial guide to the world of algorithms. Clearly presented, mathematically rigorous, and yet approachable even for the maths- averse, this title sets a high standard for a textbook and reference to the best algorithms for solving a wide range of computing problems. With sample problems and mathematical proofs demonstrating the correctness of each algorithm, this book is ideal as a textbook ... | |
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American Naturalist, Vol. 181, No. 6. (08 June 2013), pp. E125-E138, doi:10.1086/670160
posted to assortative_mating meta-analysis speciation
by fxdm
on 2013-05-19 18:35:48
along with 1 person
Wananahass
AbstractAssortative mating occurs when there is a correlation (positive or negative) between male and female phenotypes or genotypes across mated pairs. To determine the typical strength and direction of assortative mating in animals, we carried out a meta-analysis of published measures of assortative mating for a variety of phenotypic and genotypic traits in a diverse set of animal taxa. We focused on the strength of assortment within populations, excluding reproductively isolated populations and species. We collected 1,116 published correlations between mated ... | |
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Nat Rev Genet, Vol. 14, No. 6. (17 June 2013), pp. 415-426, doi:10.1038/nrg3493
posted to bioethics
by qayub
to the group Journal picks
on 2013-05-20 14:16:57
along with 1 person
jbhiatt
| |
✔ Shrinkage estimation of dispersion in Negative Binomial models for RNA-seq experiments with small sample size.[CiTO]Bioinformatics (Oxford, England), Vol. 29, No. 10. (15 May 2013), pp. 1275-1282, doi:10.1093/bioinformatics/btt143
posted to estimation rna-seq shrinkage
by djkt
on 2013-05-20 16:48:04
along with 3 people
lp2
TRHvidsten
youngl
AbstractRNA-seq experiments produce digital counts of reads that are affected by both biological and technical variation. To distinguish the systematic changes in expression between conditions from noise, the counts are frequently modeled by the Negative Binomial distribution. However, in experiments with small sample size, the per-gene estimates of the dispersion parameter are unreliable. Method: We propose a simple and effective approach for estimating the dispersions. ... | |
 (03 June 2005)
posted to environment
by Themis11
on 2013-05-21 16:25:53
/
along with 25 people and 3 groups
amb247
annemarleen
asianmonkey1
avoets
buky1992
cursonivel1
DeniseBedford
Dyonne
Flit
gpappie
irojo
jasmijnmansvelder
JGod
jtoneschoi
MelchiorH
mmustofa
mwdenboer
ovanmerle
Peter4018117
rckuipers
rubengrandia
satbiod
sdptrevizan
sscortescu
yhaartsen
biodiversity_conservation
cursonivel1
Delft Automotives
Abstract<b>One Planet, Many People</b> is intended for environmental policy makers, non-governmental organizations, the private sector, academics, teachers and citizens. This colorful and approachable atlas contains photographs, satellite images, maps and narratives that provide insights into the many ways people around the world have changed, and continue to change, the environment. <b>Objectives:</b> The main purpose of this hard-cover, 332-page, large-format atlas is to document visual evidence of global environmental changes resulting from natural processes and human-induced activities. Special objectives of One Planet, ... | |
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(11 Oct 2012)
AbstractIn scattering theory the far field pattern describes the directional dependence of a time-harmonic wave scattered by an obstacle or inhomogeneous medium, when observed sufficiently far away from these objects. Considering plane wave excitations, the far field pattern can be written as a function of two variables, namely the direction of propagation of the incident plane wave and the observation direction, and it is well-known to be separately real analytic with respect to each of them. We show that the far field pattern is in fact a jointly ... | |
✔ DrugMap Central (DMC), an on-line query and visualization tool to facilitate drug repositioning studies[CiTO]Bioinformatics (15 May 2013), doi:10.1093/bioinformatics/btt279
AbstractSummary: Systematic studies of drug repositioning require the integration of multi-level drug data, including basic chemical information (such as SMILES), drug targets, target-related signaling pathways, clinical trial information, and Food and Drug Administration (FDA) approval information, to predict new potential indications of existing drugs. Currently available databases, however, lack query support for multi-level drug information and thus are not designed to support drug repositioning studies. DrugMap Central (DMC), an online tool is developed to help fill the gap. DMC enables the ... | |
✔ Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data[CiTO]Nat Rev Genet, Vol. 14, No. 6. (9 June 2013), pp. 390-403, doi:10.1038/nrg3454
posted to chromosomal-organization review
by arjun_citeulike
on 2013-05-21 17:31:19
along with 4 people and 1 group
daveGerrard
lp2
mmsuner
sebastien_vigneau
Nuclear Architecture
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Database, Vol. 2013 (1 January 2013), doi:10.1093/database/bat025
by Damian Smedley, Anika Oellrich, Sebastian Köhler, et al.Barbara Ruef, Sanger Mouse Genetics Project, Monte Westerfield, Peter Robinson, Suzanna Lewis, Christopher Mungall
posted to annotation bioinformatics invivo moa phenotype system_biology
by psolaimani
on 2013-05-21 15:22:27
along with 3 people and 1 group
fsm
Maoringo
misonneh
Journal picks
AbstractThe ultimate goal of studying model organisms is to translate what is learned into useful knowledge about normal human biology and disease to facilitate treatment and early screening for diseases. Recent advances in genomic technologies allow for rapid generation of models with a range of targeted genotypes as well as their characterization by high-throughput phenotyping. As an abundance of phenotype data become available, only systematic analysis will facilitate valid conclusions to be drawn from these data and transferred to human diseases. ... | |
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In Comprehensive Chiroptical Spectroscopy (2012), pp. 289-316, doi:10.1002/9781118120392.ch8
posted to cd chemistry chirality circular dichroism supramolecular
by amammana1
on 2013-05-17 20:03:31
along with 1 person
gtcarroll
AbstractThis chapter contains sections titled: * Introduction * Thermal Systems * Photoactive Systems * Chemical and Mechanical Systems * References ... | |
✔ Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity[CiTO]Proceedings of the National Academy of Sciences (13 May 2013), doi:10.1073/pnas.1219451110
by Amandine Everard, Clara Belzer, Lucie Geurts, et al.Janneke P. Ouwerkerk, Céline Druart, Laure B. Bindels, Yves Guiot, Muriel Derrien, Giulio G. Muccioli, Nathalie M. Delzenne, Willem M. de Vos, Patrice D. Cani
posted to bacteria gut microbiome obesity
by djkt
to the group The human microbiome
on 2013-05-20 16:45:05
along with 2 people
ftv88
karthikraman
AbstractObesity and type 2 diabetes are characterized by altered gut microbiota, inflammation, and gut barrier disruption. Microbial composition and the mechanisms of interaction with the host that affect gut barrier function during obesity and type 2 diabetes have not been elucidated. We recently isolated Akkermansia muciniphila, which is a mucin-degrading bacterium that resides in the mucus layer. The presence of this bacterium inversely correlates with body weight in rodents and humans. However, the precise physiological roles played by this bacterium during ... | |
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Molecular Systems Biology, Vol. 9, No. 1. (14 May 2013), doi:10.1038/msb.2013.22
by Nicola Segata, Daniela Boernigen, Timothy L. Tickle, Xochitl C. Morgan, Wendy S. Garrett, Curtis Huttenhower
posted to metabolomics
by TRHvidsten
on 2013-05-17 19:44:11
along with 2 people
aaronkw
karthikraman
AbstractComplex microbial communities are an integral part of the Earth’s ecosystem and of our bodies in health and disease. In the last two decades, culture-independent approaches have provided new insights into their structure and function, with the exponentially decreasing cost of high-throughput sequencing resulting in broadly available tools for microbial surveys. However, the field remains far from reaching a technological plateau, as both computational techniques and nucleotide sequencing platforms for microbial genomic and transcriptional content continue to improve. Current microbiome analyses ... | |
✔ A gene expression restriction network mediated by sense and antisense Alu sequences located on protein-coding messenger RNAs[CiTO]BMC Genomics, Vol. 14, No. 1. (11 May 2013), 325, doi:10.1186/1471-2164-14-325
AbstractBACKGROUND:Alus are primate-specific retrotransposons which account for 10.6% of the human genome. A large number of protein-coding mRNAs are encoded with sense or antisense Alus in the un-translated regions.RESULTS:We postulated that mRNAs carrying Alus in the two opposite directions can generate double stranded RNAs, capable of regulating the levels of other Alu-carrying mRNAs post-transcriptionally. A gene expression profiling assay showed that the levels of antisense and sense Alus-carrying mRNAs were suppressed in a reversible manner by over-expression of exogenous sense and ... | |
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In Proceedings of the 17th ACM SIGKDD international conference on Knowledge discovery and data mining (2011), pp. 1100-1108, doi:10.1145/2020408.2020581
posted to human link mobility prediction social ties
by srini_nel_iisc
on 2013-05-20 06:05:08
along with 4 people
krzstefaniak
rumig
ShantanuPal
tnhh
AbstractOur understanding of how individual mobility patterns shape and impact the social network is limited, but is essential for a deeper understanding of network dynamics and evolution. This question is largely unexplored, partly due to the difficulty in obtaining large-scale society-wide data that simultaneously capture the dynamical information on individual movements and social interactions. Here we address this challenge for the first time by tracking the trajectories and communication records of 6 Million mobile phone users. We find that the similarity ... | |
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Bioinformatics (Oxford, England) (21 May 2013), doi:10.1093/bioinformatics/btt197
posted to isoform-abundance next-generation-sequencing re-annotation rna-seq
by youngl
on 2013-05-24 06:54:03
along with 1 person
sjcockell
AbstractThe estimation of isoform abundances from RNA-Seq data requires a time-intensive step of mapping reads to either an assembled or previously annotated transcriptome, followed by an optimization procedure for deconvolution of multi-mapping reads. These procedures are essential for downstream analysis such as differential expression. In cases where it is desirable to adjust the underlying annotation, for example, on the discovery of novel isoforms or errors ... | |
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J. Am. Chem. Soc., Vol. 129, No. 26. (7 June 2007), pp. 8062-8063, doi:10.1021/ja071447b
posted to cd chirality circular dichroism porphyrins supramolecular
by amammana1
on 2013-05-17 20:09:33
along with 1 person
gtcarroll
AbstractExploitation of the remarkable kinetic inertness and ability of chiral aggregates built with opposite charged porphyrins to self-replicate leads to a system able to cycle between a chiral and an ?achiral? state. ... | |
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Environmental Research Letters, Vol. 8, No. 2. (01 June 2013), 024024, doi:10.1088/1748-9326/8/2/024024
by John Cook, Dana Nuccitelli, Sarah A. Green, et al.Mark Richardson, Bärbel Winkler, Rob Painting, Robert Way, Peter Jacobs, Andrew Skuce
AbstractWe analyze the evolution of the scientific consensus on anthropogenic global warming (AGW) in the peer-reviewed scientific literature, examining 11 944 climate abstracts from 1991–2011 matching the topics 'global climate change' or 'global warming'. We find that 66.4% of abstracts expressed no position on AGW, 32.6% endorsed AGW, 0.7% rejected AGW and 0.3% were uncertain about the cause of global warming. Among abstracts expressing a position on AGW, 97.1% endorsed the consensus position that humans are causing global warming. In ... | |
✔ Experimental interrogation of the path dependence and stochasticity of protein evolution using phage-assisted continuous evolution.[CiTO]Proceedings of the National Academy of Sciences of the United States of America (14 May 2013), doi:10.1073/pnas.1220670110
AbstractTo what extent are evolutionary outcomes determined by a population's recent environment, and to what extent do they depend on historical contingency and random chance? Here we apply a unique experimental system to investigate evolutionary reproducibility and path dependence at the protein level. We combined phage-assisted continuous evolution with high-throughput sequencing to analyze evolving protein populations as they adapted to divergent and then convergent selection ... | |
✔ Creation of recombinant antigen-binding molecules derived from hybridomas secreting specific antibodies[CiTO]Nature Protocols, Vol. 8, No. 6. (16 May 2013), pp. 1125-1148, doi:10.1038/nprot.2013.057
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Genome Research (28 March 2013), doi:10.1101/gr.152710.112
AbstractAn international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms ... | |
✔ Reverberation and photoionization estimates of the Broad Line Region Radius in Low-z Quasars[CiTO](20 May 2013)
AbstractBlack Hole Mass (M_BH) estimation in quasars, especially at high redshift, involves use of single epoch spectra with s/n and resolution that permit accurate measurement of the width of a broad line assumed to be a reliable virial estimator. Coupled with an estimate of the radius of the broad line region this yields M_BH. The radius of the broad line region (BLR) may be inferred from an extrapolation of the correlation between source luminosity and reverberation derived r_BLR measures (the so-called Kaspi relation involving about 60 low z ... | |
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Science, Vol. 340, No. 6134. (17 May 2013), pp. 799-799, doi:10.1126/science.340.6134.799
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Opt. Express, Vol. 21, No. 7. (8 April 2013), pp. 7868-7874, doi:10.1364/oe.21.007868
posted to apodized citing_me coupler experiment grating silicon soi
by kristgy
on 2013-05-23 09:51:44
along with 2 people
hanss
pmunozm
AbstractWe present a high efficiency double-etched apodized fiber-to-waveguide grating coupler on a silicon-on-insulator substrate, which can be fabricated using deep UV photolithography. The fabricated grating coupler yields a coupling loss of −1.5 dB with 3-dB bandwidth of 54 nm at a wavelength of 1560 nm. Measurements and simulations show that the double-etched apodized grating coupler design is robust and tolerant to fabrication process variations. ... | |
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(15 May 2013)
posted to inference information-geometry statistics string-theory
by melvineloy
on 2013-05-19 19:50:18
along with 1 person
amozeika
AbstractIn this note we expose some surprising connections between string theory and statistical inference. We consider a large collective of agents sweeping out a family of nearby statistical models for an M-dimensional manifold of statistical fitting parameters. When the agents making nearby inferences align along a d-dimensional grid, we find that the pooled probability that the collective reaches a correct inference is the partition function of a non-linear sigma model in d dimensions. Stability under perturbations to the original inference scheme requires the agents of the collective to ... | |
✔ Searching for Cooling Signatures in Strong Lensing Galaxy Clusters: Evidence Against Baryons Shaping the Matter Distribution in Cluster Cores[CiTO](17 May 2013)
by Peter K. Blanchard, Matthew B. Bayliss, Michael McDonald, et al.Hakon Dahle, Michael D. Gladders, Keren Sharon, Richard Mushotzky
AbstractThe process by which the mass density profile of certain galaxy clusters becomes centrally concentrated enough to produce high strong lensing (SL) cross-sections is not well understood. It has been suggested that the baryonic condensation of the intra-cluster medium (ICM) due to cooling may drag dark matter to the cores and thus steepen the profile. In this work, we search for evidence of ongoing ICM cooling in the first large, well-defined sample of strong lensing selected galaxy clusters in the range 0.1 < z < 0.6. Based ... | |
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In Proceedings of the 2012 ACM SIGMOD International Conference on Management of Data (2012), pp. 779-790, doi:10.1145/2213836.2213955
AbstractBig data is the tar sands of the data world: vast reserves of raw gritty data whose valuable information content can only be extracted at great cost. MapReduce is a popular parallel programming paradigm well suited to the programmatic extraction and analysis of information from these unstructured Big Data reserves. The Apache Hadoop implementation of MapReduce has become an important player in this market due to its ability to exploit large networks of inexpensive servers. The increasing importance of unstructured data ... | |
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(20 May 2013)
AbstractWe present the COLIBRI code for computing the evolution of stars along the TP-AGB phase. Compared to purely synthetic TP-AGB codes, COLIBRI relaxes a significant part of their analytic formalism in favour of a detailed physics applied to a complete envelope model, in which the stellar structure equations are integrated from the atmosphere down to the bottom of the hydrogen-burning shell. This allows to predict self-consistently: (i) the effective temperature, and more generally the convective envelope and atmosphere structures, correctly coupled to the changes in the surface chemical ... | |
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J. Phys. Chem. B, Vol. 115, No. 40. (31 August 2011), pp. 11581-11587, doi:10.1021/jp205893y
posted to cd chirality circular dichroism dithienylethene dna electrostatic memory molecular photoswitch switch
by amammana1
on 2013-05-17 20:00:34
along with 1 person
gtcarroll
AbstractThe interesting structural, electronic, and optical properties of DNA provide fascinating opportunities for developing nanoscale smart materials by integrating DNA with opto-electronic components. In this article we demonstrate the electrostatic binding of an amine-terminated dithienylethene (DET) molecular switch to double-stranded synthetic polynucleotides. The DET switch can undergo photochemical ring-closure and opening reactions. Circular dichroism (CD) and UV?vis spectroscopy show that both the open, 1o, and the closed, 1c, forms of the switch bind to DNA. Upon addition of DNA to a ... | |
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In 2013 International Conference on Computing, Networking and Communications (ICNC) (January 2013), pp. 1123-1127, doi:10.1109/iccnc.2013.6504250
posted to cloud-computing epfl_mobility mobile-cloud surveillance uses_crawdad_data vehicular
by ShantanuPal
on 2013-05-23 11:19:01
along with 1 person and 1 group
tnhh
CRAWDAD
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