Meta-analysis: Lactobacillus GG for treating acute diarrhoea in children. Export

@article{citeulike:2711277, abstract = {Aim: To review evidence for the effectiveness of Lactobacillus GG (LGG) in treating acute infectious diarrhoea in children. Methods: The following electronic databases were searched through August 2006 for studies relevant to acute infectious diarrhoea and LGG: MEDLINE, EMBASE, CINAHL and The Cochrane Library; additional references were obtained from reviewed articles. Only randomized-controlled trials (RCTs) were included. Results: Eight RCTs (988 participants) met the inclusion criteria. Compared with controls, LGG had no effect on the total stool volume (two RCTs, n = 303). However, LGG was associated with a significant reduction in diarrhoea duration (seven RCTs, 876 infants, weighted mean difference, WMD -1.1 days (95\% confidence interval, CI -1.9 to -0.3), particularly of rotavirus etiology (WMD -2.1 days, 95\% CI -3.6 to -0.6), risk of diarrhoea >7 days (one RCT, n = 287, relative risk 0.25, 95\% CI 0.09-0.75) and duration of hospitalization (three RCTs, n = 535, WMD -0.58, 95\% CI -0.8 to -0.4; significance was lost in the random effect model). There was no reduction in the number of stools at any time interval. Conclusions: The use of LGG is associated with moderate clinical benefits in the treatment of acute diarrhoea in children. These findings should be interpreted with caution due to the important methodological limitations and heterogeneity of most of the studies. Copyright (C) 2007 Blackwell Publishing Ltd.}, author = {Szajewska, H. and Skorka, A. and Ruszczynski, M. and Gieruszczak-Bialek, D.}, citeulike-article-id = {2711277}, citeulike-linkout-0 = {http://pt.wkhealth.com/pt/re/alpt/abstract.00001716-200704080-00002.htm;jsessionid=LP2PFlj9cvg4JqhhktLRg8w29M2vmc8TL1tlhrNVDhnH0HVJcRD7!553210824!181195629!8091!-1}, journal = {Alimentary Pharmacology \& Therapeutics.}, keywords = {children, diarrhea, probiotics}, month = {April}, number = {8}, pages = {871--881}, posted-at = {2008-04-24 03:57:45}, priority = {0}, title = {Meta-analysis: Lactobacillus GG for treating acute diarrhoea in children.}, url = {http://pt.wkhealth.com/pt/re/alpt/abstract.00001716-200704080-00002.htm;jsessionid=LP2PFlj9cvg4JqhhktLRg8w29M2vmc8TL1tlhrNVDhnH0HVJcRD7!553210824!181195629!8091!-1}, volume = {25}, year = {2007} }

TY - JOUR ID - citeulike:2711277 L3 - citeulike-article-id:2711277 N2 - Aim: To review evidence for the effectiveness of Lactobacillus GG (LGG) in treating acute infectious diarrhoea in children. Methods: The following electronic databases were searched through August 2006 for studies relevant to acute infectious diarrhoea and LGG: MEDLINE, EMBASE, CINAHL and The Cochrane Library; additional references were obtained from reviewed articles. Only randomized-controlled trials (RCTs) were included. Results: Eight RCTs (988 participants) met the inclusion criteria. Compared with controls, LGG had no effect on the total stool volume (two RCTs, n = 303). However, LGG was associated with a significant reduction in diarrhoea duration (seven RCTs, 876 infants, weighted mean difference, WMD -1.1 days (95% confidence interval, CI -1.9 to -0.3), particularly of rotavirus etiology (WMD -2.1 days, 95% CI -3.6 to -0.6), risk of diarrhoea >7 days (one RCT, n = 287, relative risk 0.25, 95% CI 0.09-0.75) and duration of hospitalization (three RCTs, n = 535, WMD -0.58, 95% CI -0.8 to -0.4; significance was lost in the random effect model). There was no reduction in the number of stools at any time interval. Conclusions: The use of LGG is associated with moderate clinical benefits in the treatment of acute diarrhoea in children. These findings should be interpreted with caution due to the important methodological limitations and heterogeneity of most of the studies. Copyright (C) 2007 Blackwell Publishing Ltd. IS - 8 JF - Alimentary Pharmacology & Therapeutics. EP - 881 TI - Meta-analysis: Lactobacillus GG for treating acute diarrhoea in children. VL - 25 SP - 871 KW - children KW - diarrhea KW - probiotics AU - Szajewska, H AU - Skorka, A AU - Ruszczynski, M AU - Gieruszczak-Bialek, D PY - 2007/04// UR - http://pt.wkhealth.com/pt/re/alpt/abstract.00001716-200704080-00002.htm;jsessionid=LP2PFlj9cvg4JqhhktLRg8w29M2vmc8TL1tlhrNVDhnH0HVJcRD7!553210824!181195629!8091!-1 ER -