Chemical space and biology Export

@article{citeulike:3916, abstract = {Chemical space — which encompasses all possible small organic molecules, including those present in biological systems — is vast. So vast, in fact, that so far only a tiny fraction of it has been explored. Nevertheless, these explorations have greatly enhanced our understanding of biology, and have led to the development of many of today's drugs. The discovery of new bioactive molecules, facilitated by a deeper understanding of the nature of the regions of chemical space that are relevant to biology, will advance our knowledge of biological processes and lead to new strategies to treat disease.}, author = {Dobson, Christopher M.}, citeulike-article-id = {3916}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nature03192}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nature03192}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/15602547}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=15602547}, day = {15}, doi = {10.1038/nature03192}, issn = {0028-0836}, journal = {Nature}, keywords = {chemistry, minor-proposal}, month = {December}, number = {7019}, pages = {824--828}, posted-at = {2006-12-07 01:08:17}, priority = {5}, publisher = {Nature Publishing Group}, title = {Chemical space and biology}, url = {http://dx.doi.org/10.1038/nature03192}, volume = {432}, year = {2004} }

TY - JOUR ID - citeulike:3916 L3 - citeulike-article-id:3916 N2 - Chemical space — which encompasses all possible small organic molecules, including those present in biological systems — is vast. So vast, in fact, that so far only a tiny fraction of it has been explored. Nevertheless, these explorations have greatly enhanced our understanding of biology, and have led to the development of many of today's drugs. The discovery of new bioactive molecules, facilitated by a deeper understanding of the nature of the regions of chemical space that are relevant to biology, will advance our knowledge of biological processes and lead to new strategies to treat disease. IS - 7019 JF - Nature SN - 0028-0836 EP - 828 TI - Chemical space and biology PB - Nature Publishing Group VL - 432 SP - 824 KW - chemistry KW - minor-proposal AU - Dobson, Christopher PY - 2004/12/15/ UR - http://dx.doi.org/10.1038/nature03192 ER -