Keynote review: Structural biology and drug discovery Export

@article{citeulike:801082, abstract = {It has long been recognized that knowledge of the 3D structures of proteins has the potential to accelerate drug discovery, but recent developments in genome sequencing, robotics and bioinformatics have radically transformed the opportunities. Many new protein targets have been identified from genome analyses and studied by X-ray analysis or NMR spectroscopy. Structural biology has been instrumental in directing not only lead optimization and target identification, where it has well-established roles, but also lead discovery, now that high-throughput methods of structure determination can provide powerful approaches to screening.}, author = {Congreve, Miles and Murray, Christopher W. and Blundell, Tom L.}, citeulike-article-id = {801082}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/S1359-6446(05)03484-7}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15993809}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15993809}, citeulike-linkout-3 = {http://www.sciencedirect.com/science/article/B6T64-4GHS7KC-B/2/09fbc2591f56cad1f0654ff4d3d04a1e}, day = {1}, doi = {10.1016/S1359-6446(05)03484-7}, journal = {Drug Discovery Today}, keywords = {bioinformatics, drug-design, high-throughput, structural-biology}, month = {July}, number = {13}, pages = {895--907}, posted-at = {2006-08-14 18:25:23}, priority = {5}, title = {Keynote review: Structural biology and drug discovery}, url = {http://dx.doi.org/10.1016/S1359-6446(05)03484-7}, volume = {10}, year = {2005} }

TY - JOUR ID - citeulike:801082 L3 - citeulike-article-id:801082 N2 - It has long been recognized that knowledge of the 3D structures of proteins has the potential to accelerate drug discovery, but recent developments in genome sequencing, robotics and bioinformatics have radically transformed the opportunities. Many new protein targets have been identified from genome analyses and studied by X-ray analysis or NMR spectroscopy. Structural biology has been instrumental in directing not only lead optimization and target identification, where it has well-established roles, but also lead discovery, now that high-throughput methods of structure determination can provide powerful approaches to screening. IS - 13 JF - Drug Discovery Today EP - 907 TI - Keynote review: Structural biology and drug discovery VL - 10 SP - 895 KW - bioinformatics KW - drug-design KW - high-throughput KW - structural-biology AU - Congreve, Miles AU - Murray, Christopher AU - Blundell, Tom PY - 2005/07/01/ UR - http://dx.doi.org/10.1016/S1359-6446(05)03484-7 ER -