Warmr: a data mining tool for chemical data. Export

@article{citeulike:822468, abstract = {Data mining techniques are becoming increasingly important in chemistry as databases become too large to examine manually. Data mining methods from the field of Inductive Logic Programming (ILP) have potential advantages for structural chemical data. In this paper we present Warmr, the first ILP data mining algorithm to be applied to chemoinformatic data. We illustrate the value of Warmr by applying it to a well studied database of chemical compounds tested for carcinogenicity in rodents. Data mining was used to find all frequent substructures in the database, and knowledge of these frequent substructures is shown to add value to the database. One use of the frequent substructures was to convert them into probabilistic prediction rules relating compound description to carcinogenesis. These rules were found to be accurate on test data, and to give some insight into the relationship between structure and activity in carcinogenesis. The substructures were also used to prove that there existed no accurate rule, based purely on atom-bond substructure with less than seven conditions, that could predict carcinogenicity. This results put a lower bound on the complexity of the relationship between chemical structure and carcinogenicity. Only by using a data mining algorithm, and by doing a complete search, is it possible to prove such a result. Finally the frequent substructures were shown to add value by increasing the accuracy of statistical and machine learning programs that were trained to predict chemical carcinogenicity. We conclude that Warmr, and ILP data mining methods generally, are an important new tool for analysing chemical databases.}, address = {Department of Computer Science, University of Wales, Aberystwyth Penglais, Ceredigion, UK.}, author = {King, R. D. and Srinivasan, A. and Dehaspe, L.}, citeulike-article-id = {822468}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/11272703}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=11272703}, issn = {0920-654X}, journal = {J Comput Aided Mol Des}, keywords = {chemistry, comps, data-mining, minor-proposal}, month = {February}, number = {2}, pages = {173--181}, posted-at = {2006-08-31 00:38:43}, priority = {5}, title = {Warmr: a data mining tool for chemical data.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/11272703}, volume = {15}, year = {2001} }

TY - JOUR ID - citeulike:822468 L3 - citeulike-article-id:822468 N2 - Data mining techniques are becoming increasingly important in chemistry as databases become too large to examine manually. Data mining methods from the field of Inductive Logic Programming (ILP) have potential advantages for structural chemical data. In this paper we present Warmr, the first ILP data mining algorithm to be applied to chemoinformatic data. We illustrate the value of Warmr by applying it to a well studied database of chemical compounds tested for carcinogenicity in rodents. Data mining was used to find all frequent substructures in the database, and knowledge of these frequent substructures is shown to add value to the database. One use of the frequent substructures was to convert them into probabilistic prediction rules relating compound description to carcinogenesis. These rules were found to be accurate on test data, and to give some insight into the relationship between structure and activity in carcinogenesis. The substructures were also used to prove that there existed no accurate rule, based purely on atom-bond substructure with less than seven conditions, that could predict carcinogenicity. This results put a lower bound on the complexity of the relationship between chemical structure and carcinogenicity. Only by using a data mining algorithm, and by doing a complete search, is it possible to prove such a result. Finally the frequent substructures were shown to add value by increasing the accuracy of statistical and machine learning programs that were trained to predict chemical carcinogenicity. We conclude that Warmr, and ILP data mining methods generally, are an important new tool for analysing chemical databases. IS - 2 JF - J Comput Aided Mol Des SN - 0920-654X AD - Department of Computer Science, University of Wales, Aberystwyth Penglais, Ceredigion, UK. EP - 181 TI - Warmr: a data mining tool for chemical data. VL - 15 SP - 173 KW - chemistry KW - comps KW - data-mining KW - minor-proposal AU - King, RD AU - Srinivasan, A AU - Dehaspe, L PY - 2001/02// UR - http://view.ncbi.nlm.nih.gov/pubmed/11272703 ER -