Subthreshold depressive disorder in adolescents: predictors of escalation to full-syndrome depressive disorders. Export

@article{citeulike:5206087, abstract = {OBJECTIVES: Subthreshold depressive disorder is one of the best established risk factors for the onset of full-syndrome depressive disorders. However, many youths with subthreshold depressive disorder do not develop full-syndrome depression. We examined predictors of escalation to full-syndrome depressive disorders in a community sample of 225 adolescents with subthreshold depressive disorder. METHOD: Criteria for subthreshold depressive disorder were an episode of depressed mood or loss of interest or pleasure lasting at least 1 week and at least two of the seven other DSM-IV-associated symptoms for major depression. Participants were assessed four times from mid-adolescence to age 30 years using semistructured diagnostic interviews. RESULTS: The estimated risk for escalation to full-syndrome depressive disorders was 67\%. Five variables accounted for unique variance in predicting escalation: severity of depressive symptoms, medical conditions/symptoms, history of suicidal ideation, history of anxiety disorder, and familial loading for depression. Adolescents with three or more risk factors had an estimated 90\% chance of escalating to full-syndrome depressive disorder, compared with 47\% of adolescents with fewer than three risk factors. CONCLUSIONS: These data may be useful in identifying a subgroup of youths with subthreshold depressive disorder who are at especially high risk for escalating to full-syndrome depressive disorders.}, author = {Klein, D. N. and Shankman, S. A. and Lewinsohn, P. M. and Seeley, J. R.}, citeulike-article-id = {5206087}, citeulike-linkout-0 = {http://dx.doi.org/10.1097/CHI.0b013e3181a56606}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19465876}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19465876}, doi = {10.1097/CHI.0b013e3181a56606}, issn = {1527-5418}, journal = {Journal of the American Academy of Child and Adolescent Psychiatry}, keywords = {adolescence, depression}, month = {July}, number = {7}, pages = {703--710}, posted-at = {2009-07-20 03:47:35}, priority = {0}, title = {Subthreshold depressive disorder in adolescents: predictors of escalation to full-syndrome depressive disorders.}, url = {http://dx.doi.org/10.1097/CHI.0b013e3181a56606}, volume = {48}, year = {2009} }

TY - JOUR ID - citeulike:5206087 L3 - citeulike-article-id:5206087 N2 - OBJECTIVES: Subthreshold depressive disorder is one of the best established risk factors for the onset of full-syndrome depressive disorders. However, many youths with subthreshold depressive disorder do not develop full-syndrome depression. We examined predictors of escalation to full-syndrome depressive disorders in a community sample of 225 adolescents with subthreshold depressive disorder. METHOD: Criteria for subthreshold depressive disorder were an episode of depressed mood or loss of interest or pleasure lasting at least 1 week and at least two of the seven other DSM-IV-associated symptoms for major depression. Participants were assessed four times from mid-adolescence to age 30 years using semistructured diagnostic interviews. RESULTS: The estimated risk for escalation to full-syndrome depressive disorders was 67%. Five variables accounted for unique variance in predicting escalation: severity of depressive symptoms, medical conditions/symptoms, history of suicidal ideation, history of anxiety disorder, and familial loading for depression. Adolescents with three or more risk factors had an estimated 90% chance of escalating to full-syndrome depressive disorder, compared with 47% of adolescents with fewer than three risk factors. CONCLUSIONS: These data may be useful in identifying a subgroup of youths with subthreshold depressive disorder who are at especially high risk for escalating to full-syndrome depressive disorders. IS - 7 JF - Journal of the American Academy of Child and Adolescent Psychiatry SN - 1527-5418 EP - 710 TI - Subthreshold depressive disorder in adolescents: predictors of escalation to full-syndrome depressive disorders. VL - 48 SP - 703 KW - adolescence KW - depression AU - Klein, DN AU - Shankman, SA AU - Lewinsohn, PM AU - Seeley, JR PY - 2009/07// UR - http://dx.doi.org/10.1097/CHI.0b013e3181a56606 ER -