Global synthetic-lethality analysis and yeast functional profiling. Export

@article{citeulike:556710, abstract = {The Saccharomyces genome-deletion project created >5900 'molecularly barcoded' yeast knockout mutants (YKO mutants). The YKO mutant collections have facilitated large-scale analyses of a multitude of mutant phenotypes. For example, both synthetic genetic array (SGA) and synthetic-lethality analysis by microarray (SLAM) methods have been used for synthetic-lethality screens. Global analysis of synthetic lethality promises to identify cellular pathways that 'buffer' each other biologically. The combination of global synthetic-lethality analysis, together with global protein-protein interaction analyses, mRNA expression profiling and functional profiling will, in principle, enable construction of a cellular 'wiring diagram' that will help frame a deeper understanding of human biology and disease.}, address = {High Throughput Biology Center, Institute of Genetic Medicine, Department of Biostatistics, Johns Hopkins University School of Medicine, 339 Broadway Research Building, 733 North Broadway, Baltimore, MD 21205, USA.}, author = {Ooi, S. L. and Pan, X. and Peyser, B. D. and Ye, P. and Meluh, P. B. and Yuan, D. S. and Irizarry, R. A. and Bader, J. S. and Spencer, F. A. and Boeke, J. D.}, citeulike-article-id = {556710}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.tig.2005.11.003}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16309778}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16309778}, doi = {10.1016/j.tig.2005.11.003}, issn = {0168-9525}, journal = {Trends Genet}, keywords = {synthetic-lethal, yeast}, month = {January}, number = {1}, pages = {56--63}, posted-at = {2006-04-18 20:36:00}, priority = {2}, title = {Global synthetic-lethality analysis and yeast functional profiling.}, url = {http://dx.doi.org/10.1016/j.tig.2005.11.003}, volume = {22}, year = {2006} }

TY - JOUR ID - citeulike:556710 L3 - citeulike-article-id:556710 N2 - The Saccharomyces genome-deletion project created >5900 'molecularly barcoded' yeast knockout mutants (YKO mutants). The YKO mutant collections have facilitated large-scale analyses of a multitude of mutant phenotypes. For example, both synthetic genetic array (SGA) and synthetic-lethality analysis by microarray (SLAM) methods have been used for synthetic-lethality screens. Global analysis of synthetic lethality promises to identify cellular pathways that 'buffer' each other biologically. The combination of global synthetic-lethality analysis, together with global protein-protein interaction analyses, mRNA expression profiling and functional profiling will, in principle, enable construction of a cellular 'wiring diagram' that will help frame a deeper understanding of human biology and disease. IS - 1 JF - Trends Genet SN - 0168-9525 AD - High Throughput Biology Center, Institute of Genetic Medicine, Department of Biostatistics, Johns Hopkins University School of Medicine, 339 Broadway Research Building, 733 North Broadway, Baltimore, MD 21205, USA. EP - 63 TI - Global synthetic-lethality analysis and yeast functional profiling. VL - 22 SP - 56 KW - synthetic-lethal KW - yeast AU - Ooi, SL AU - Pan, X AU - Peyser, BD AU - Ye, P AU - Meluh, PB AU - Yuan, DS AU - Irizarry, RA AU - Bader, JS AU - Spencer, FA AU - Boeke, JD PY - 2006/01// UR - http://dx.doi.org/10.1016/j.tig.2005.11.003 ER -