Activated signal transduction kinases frequently occupy target genes. Export

@article{citeulike:781643, abstract = {Cellular signal transduction pathways modify gene expression programs in response to changes in the environment, but the mechanisms by which these pathways regulate populations of genes under their control are not entirely understood. We present evidence that most mitogen-activated protein kinases and protein kinase A subunits become physically associated with the genes that they regulate in the yeast (Saccharomyces cerevisiae) genome. The ability to detect this interaction of signaling kinases with target genes can be used to more precisely and comprehensively map the regulatory circuitry that eukaryotic cells use to respond to their environment.}, address = {Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.}, author = {Pokholok, D. K. and Zeitlinger, J. and Hannett, N. M. and Reynolds, D. B. and Young, R. A.}, citeulike-article-id = {781643}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1127677}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/313/5786/533}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/16873666}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=16873666}, day = {28}, doi = {10.1126/science.1127677}, issn = {1095-9203}, journal = {Science}, keywords = {kinases, signalling, yeast}, month = {July}, number = {5786}, pages = {533--536}, posted-at = {2006-08-01 14:15:11}, priority = {2}, title = {Activated signal transduction kinases frequently occupy target genes.}, url = {http://dx.doi.org/10.1126/science.1127677}, volume = {313}, year = {2006} }

TY - JOUR ID - citeulike:781643 L3 - citeulike-article-id:781643 N2 - Cellular signal transduction pathways modify gene expression programs in response to changes in the environment, but the mechanisms by which these pathways regulate populations of genes under their control are not entirely understood. We present evidence that most mitogen-activated protein kinases and protein kinase A subunits become physically associated with the genes that they regulate in the yeast (Saccharomyces cerevisiae) genome. The ability to detect this interaction of signaling kinases with target genes can be used to more precisely and comprehensively map the regulatory circuitry that eukaryotic cells use to respond to their environment. IS - 5786 JF - Science SN - 1095-9203 AD - Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA. EP - 536 TI - Activated signal transduction kinases frequently occupy target genes. VL - 313 SP - 533 KW - kinases KW - signalling KW - yeast AU - Pokholok, DK AU - Zeitlinger, J AU - Hannett, NM AU - Reynolds, DB AU - Young, RA PY - 2006/07/28/ UR - http://dx.doi.org/10.1126/science.1127677 ER -