Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. Export

@article{citeulike:804194, abstract = {Mammalian genomes carry hundreds of Kr\"{u}ppel-type zinc finger (ZNF) genes, most of which reside in familial clusters. ZNF genes encoding Kr\"{u}ppel-associated box (KRAB) motifs are especially prone to this type of tandem organization. Despite their prevalence, little is known about the functions or evolutionary histories of these clustered gene families. Here we describe a homologous pair of human and mouse KRAB-ZNF gene clusters containing 21 human and 10 mouse genes, respectively. Evolutionary analysis uncovered only three pairs of putative orthologs and two cases where a single gene in one species is related to multiple genes in the other; several human genes have no obvious homolog in mouse. We deduce that duplication and loss of ancestral cluster members occurred independently in the primate and rodent lineages after divergence, yielding substantially different ZNF gene repertoires in humans and mice. Differences in expression patterns and sequence divergence within the DNA binding regions of predicted proteins suggest that the duplicated genes have acquired novel functions over evolutionary time. Since KRAB-ZNF proteins are predicted to function as transcriptional regulators, the elaboration of new lineage-specific genes in this and other clustered ZNF families is likely to have had a significant impact on species-specific aspects of biology.}, address = {Genome Biology Division, Lawrence Livermore National Laboratory, Livermore, California 94550, USA.}, author = {Shannon, M. and Hamilton, A. T. and Gordon, L. and Branscomb, E. and Stubbs, L.}, citeulike-article-id = {804194}, citeulike-linkout-0 = {http://dx.doi.org/10.1101/gr.963903}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/12743021}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=12743021}, doi = {10.1101/gr.963903}, issn = {1088-9051}, journal = {Genome Res}, keywords = {human, tf}, month = {June}, number = {6A}, pages = {1097--1110}, posted-at = {2006-08-17 14:46:24}, priority = {2}, title = {Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.}, url = {http://dx.doi.org/10.1101/gr.963903}, volume = {13}, year = {2003} }

TY - JOUR ID - citeulike:804194 L3 - citeulike-article-id:804194 N2 - Mammalian genomes carry hundreds of Krüppel-type zinc finger (ZNF) genes, most of which reside in familial clusters. ZNF genes encoding Krüppel-associated box (KRAB) motifs are especially prone to this type of tandem organization. Despite their prevalence, little is known about the functions or evolutionary histories of these clustered gene families. Here we describe a homologous pair of human and mouse KRAB-ZNF gene clusters containing 21 human and 10 mouse genes, respectively. Evolutionary analysis uncovered only three pairs of putative orthologs and two cases where a single gene in one species is related to multiple genes in the other; several human genes have no obvious homolog in mouse. We deduce that duplication and loss of ancestral cluster members occurred independently in the primate and rodent lineages after divergence, yielding substantially different ZNF gene repertoires in humans and mice. Differences in expression patterns and sequence divergence within the DNA binding regions of predicted proteins suggest that the duplicated genes have acquired novel functions over evolutionary time. Since KRAB-ZNF proteins are predicted to function as transcriptional regulators, the elaboration of new lineage-specific genes in this and other clustered ZNF families is likely to have had a significant impact on species-specific aspects of biology. IS - 6A JF - Genome Res SN - 1088-9051 AD - Genome Biology Division, Lawrence Livermore National Laboratory, Livermore, California 94550, USA. EP - 1110 TI - Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. VL - 13 SP - 1097 KW - human KW - tf AU - Shannon, M AU - Hamilton, AT AU - Gordon, L AU - Branscomb, E AU - Stubbs, L PY - 2003/06// UR - http://dx.doi.org/10.1101/gr.963903 ER -