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Long non-coding RNA gadd7 interacts with TDP-43 and regulates Cdk6 mRNA decay

by: Xuefeng Liu, Dan Li, Weimin Zhang, Mingzhou Guo, Qimin Zhan
EMBO J, Vol. 31, No. 23. (28 November 2012), pp. 4415-4427, doi:10.1038/emboj.2012.292  Key: citeulike:11565170

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Abstract

Long non-coding RNA gadd7 interacts with TDP-43 and regulates Cdk6 mRNA decayExpression of the long non-coding RNA gadd7 is induced by DNA damage. New findings show that gadd7 controls the G1/S damage checkpoint by interacting with the RNA-binding protein TDP-43, thereby inducing Cdk6 mRNA degradation.


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