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The genomes of four tapeworm species reveal adaptations to parasitism

by: Isheng J. Tsai, Magdalena Zarowiecki, Nancy Holroyd, Alejandro Garciarrubio, Alejandro Sanchez-Flores, Karen L. Brooks, Alan Tracey, Raul J. Bobes, Gladis Fragoso, Edda Sciutto, Martin Aslett, Helen Beasley, Hayley M. Bennett, Jianping Cai, Federico Camicia, Richard Clark, Marcela Cucher, Nishadi De Silva, Tim A. Day, Peter Deplazes, Karel Estrada, Cecilia Fernandez, Peter W. H. Holland, Junling Hou, Songnian Hu, Thomas Huckvale, Stacy S. Hung, Laura Kamenetzky, Jacqueline A. Keane, Ferenc Kiss, Uriel Koziol, Olivia Lambert, Kan Liu, Xuenong Luo, Yingfeng Luo, Natalia Macchiaroli, Sarah Nichol, Jordi Paps, John Parkinson, Natasha Pouchkina-Stantcheva, Nick Riddiford, Mara Rosenzvit, Gustavo Salinas, James D. Wasmuth, Mostafa Zamanian, Yadong Zheng, Xuepeng Cai, Xavier Soberon, Peter D. Olson, Juan P. Laclette, Klaus Brehm, Matthew Berriman
Nature, Vol. advance online publication (13 March 2013), doi:10.1038/nature12031  Key: citeulike:12165083

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Abstract

Genome sequences of human-infective tapeworm species reveal extreme losses of genes and pathways that are ubiquitous in other animals, species-specific expansions of non-canonical heat shock proteins and families of known antigens, specialized detoxification pathways, and metabolism that relies on host nutrients; this information is used to identify new potential drug targets.


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