The pharmacogenetics of CYP2C9 and CYP2C19: ethnic variation and clinical significance. Export

@article{citeulike:5430072, abstract = {CYP2C9 and CYP2C19 are important drug metabolizing enzymes and together metabolize about 18\% of currently available drugs. Some of the important groups of drugs that are metabolized by them are antihypertensives, hypoglycemics, anticonvulsants, antiulcer drugs etc. Genes encoding these enzymes are polymorphically expressed. Thirty variant alleles for CYP2C9 and 21 for CYP2C19 have been reported. The frequencies of these polymorphic alleles show marked inter-ethnic variation. Several reports have been published showing the clinical importance of this polymorphism. This review summarizes the currently available important information on this topic.}, author = {Rosemary, J. and Adithan, C.}, citeulike-article-id = {5430072}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/18690857}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=18690857}, issn = {1574-8847}, journal = {Current clinical pharmacology}, keywords = {cyp2c19, cyp2c9, indian, nnn}, month = {January}, number = {1}, pages = {93--109}, posted-at = {2009-08-13 01:26:38}, priority = {2}, title = {The pharmacogenetics of CYP2C9 and CYP2C19: ethnic variation and clinical significance.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/18690857}, volume = {2}, year = {2007} }

TY - JOUR ID - citeulike:5430072 L3 - citeulike-article-id:5430072 N2 - CYP2C9 and CYP2C19 are important drug metabolizing enzymes and together metabolize about 18% of currently available drugs. Some of the important groups of drugs that are metabolized by them are antihypertensives, hypoglycemics, anticonvulsants, antiulcer drugs etc. Genes encoding these enzymes are polymorphically expressed. Thirty variant alleles for CYP2C9 and 21 for CYP2C19 have been reported. The frequencies of these polymorphic alleles show marked inter-ethnic variation. Several reports have been published showing the clinical importance of this polymorphism. This review summarizes the currently available important information on this topic. IS - 1 JF - Current clinical pharmacology SN - 1574-8847 EP - 109 TI - The pharmacogenetics of CYP2C9 and CYP2C19: ethnic variation and clinical significance. VL - 2 SP - 93 KW - cyp2c19 KW - cyp2c9 KW - indian KW - nnn AU - Rosemary, J AU - Adithan, C PY - 2007/01// UR - http://view.ncbi.nlm.nih.gov/pubmed/18690857 ER -