Dose-response relationships of propranolol in Chinese subjects with different CYP2D6 genotypes. Export

@article{citeulike:6100335, abstract = {BACKGROUND: For clinical treatment, a smaller dosage of propranolol is often used among Chinese people. Propranolol is metabolized by polymorphic CYP2D6. We postulate that the lower propranolol dosage in Chinese is due to a slower CYP2D6 metabolism. A majority of the Chinese population has the nucleotide T188 in the CYP2D6 gene (CYP2D6*10) instead of C188 (CYP2D6*1), which most white subjects have. Chinese subjects of different CYP2D6*1/CYP2D6*10 genotypes have been shown to have different propranolol pharmacokinetic characteristics. In this study, we compared the beta-blockade effects of propranolol in Chinese subjects of the two different CYP2D6 genotypes. METHODS: Based on the nucleotide 188 genotypes, two groups of 10 healthy subjects each were selected. Each subject was given a 10-, 20-, or 40-mg rac-propranolol tablet three times a day for 3 days in 3 different phases. Heart rate and blood pressure were measured in both supine and upright positions. The heart rate was also determined during treadmill exercise test. Plasma concentration of S-propranolol at 2 hrs after the last-dose administration was measured. RESULTS: Despite therebeing higher S-propranolol plasma concentration in CYP2D6*10 subjects than in CYP2D6*1 subjects at 10- and 20-mg dosage, the dose-response relationship was not significantly different in these subjects. CONCLUSIONS: Our results do not support the hypothesis that CYP2D6*1/CYP2D6*10 polymorphism may affect the beta-blockade effect of propranolol in Chinese subjects.}, author = {Huang, Chin-Wei W. and Lai, Ming-Liang L. and Lin, Min-Shung S. and Lee, Hwei-Ling L. and Huang, Jin-Ding D.}, citeulike-article-id = {6100335}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/12728976}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=12728976}, issn = {1726-4901}, journal = {Journal of the Chinese Medical Association : JCMA}, keywords = {cyp2d6, taiwan}, month = {January}, number = {1}, pages = {57--62}, posted-at = {2009-11-12 01:27:06}, priority = {2}, title = {Dose-response relationships of propranolol in Chinese subjects with different CYP2D6 genotypes.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12728976}, volume = {66}, year = {2003} }

TY - JOUR ID - citeulike:6100335 L3 - citeulike-article-id:6100335 N2 - BACKGROUND: For clinical treatment, a smaller dosage of propranolol is often used among Chinese people. Propranolol is metabolized by polymorphic CYP2D6. We postulate that the lower propranolol dosage in Chinese is due to a slower CYP2D6 metabolism. A majority of the Chinese population has the nucleotide T188 in the CYP2D6 gene (CYP2D6*10) instead of C188 (CYP2D6*1), which most white subjects have. Chinese subjects of different CYP2D6*1/CYP2D6*10 genotypes have been shown to have different propranolol pharmacokinetic characteristics. In this study, we compared the beta-blockade effects of propranolol in Chinese subjects of the two different CYP2D6 genotypes. METHODS: Based on the nucleotide 188 genotypes, two groups of 10 healthy subjects each were selected. Each subject was given a 10-, 20-, or 40-mg rac-propranolol tablet three times a day for 3 days in 3 different phases. Heart rate and blood pressure were measured in both supine and upright positions. The heart rate was also determined during treadmill exercise test. Plasma concentration of S-propranolol at 2 hrs after the last-dose administration was measured. RESULTS: Despite therebeing higher S-propranolol plasma concentration in CYP2D6*10 subjects than in CYP2D6*1 subjects at 10- and 20-mg dosage, the dose-response relationship was not significantly different in these subjects. CONCLUSIONS: Our results do not support the hypothesis that CYP2D6*1/CYP2D6*10 polymorphism may affect the beta-blockade effect of propranolol in Chinese subjects. IS - 1 JF - Journal of the Chinese Medical Association : JCMA SN - 1726-4901 EP - 62 TI - Dose-response relationships of propranolol in Chinese subjects with different CYP2D6 genotypes. VL - 66 SP - 57 KW - cyp2d6 KW - taiwan AU - Huang, Chin-Wei AU - Lai, Ming-Liang AU - Lin, Min-Shung AU - Lee, Hwei-Ling AU - Huang, Jin-Ding PY - 2003/01// UR - http://view.ncbi.nlm.nih.gov/pubmed/12728976 ER -