A clinicopathological study of autism. Export

@article{citeulike:1455995, abstract = {A neuropathological study of autism was established and brain tissue examined from six mentally handicapped subjects with autism. Clinical and educational records were obtained and standardized diagnostic interviews conducted with the parents of cases not seen before death. Four of the six brains were megalencephalic, and areas of cortical abnormality were identified in four cases. There were also developmental abnormalities of the brainstem, particularly of the inferior olives. Purkinje cell number was reduced in all the adult cases, and this reduction was sometimes accompanied by gliosis. The findings do not support previous claims of localized neurodevelopmental abnormalities. They do point to the likely involvement of the cerebral cortex in autism.}, address = {MRC Child Psychiatry Unit, Institute of Psychiatry, London, UK.}, author = {Bailey, A. and Luthert, P. and Dean, A. and Harding, B. and Janota, I. and Montgomery, M. and Rutter, M. and Lantos, P.}, citeulike-article-id = {1455995}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/brain/121.5.889}, citeulike-linkout-1 = {http://brain.oxfordjournals.org/cgi/content/abstract/121/5/889}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/9619192}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=9619192}, doi = {10.1093/brain/121.5.889}, issn = {0006-8950}, journal = {Brain}, keywords = {autism, medicine}, month = {May}, pages = {889--905}, posted-at = {2007-07-14 09:02:34}, priority = {0}, title = {A clinicopathological study of autism.}, url = {http://dx.doi.org/10.1093/brain/121.5.889}, volume = {121 ( Pt 5)}, year = {1998} }

TY - JOUR ID - citeulike:1455995 L3 - citeulike-article-id:1455995 N2 - A neuropathological study of autism was established and brain tissue examined from six mentally handicapped subjects with autism. Clinical and educational records were obtained and standardized diagnostic interviews conducted with the parents of cases not seen before death. Four of the six brains were megalencephalic, and areas of cortical abnormality were identified in four cases. There were also developmental abnormalities of the brainstem, particularly of the inferior olives. Purkinje cell number was reduced in all the adult cases, and this reduction was sometimes accompanied by gliosis. The findings do not support previous claims of localized neurodevelopmental abnormalities. They do point to the likely involvement of the cerebral cortex in autism. JF - Brain SN - 0006-8950 AD - MRC Child Psychiatry Unit, Institute of Psychiatry, London, UK. EP - 905 TI - A clinicopathological study of autism. VL - 121 ( Pt 5) SP - 889 KW - autism KW - medicine AU - Bailey, A AU - Luthert, P AU - Dean, A AU - Harding, B AU - Janota, I AU - Montgomery, M AU - Rutter, M AU - Lantos, P PY - 1998/05// UR - http://dx.doi.org/10.1093/brain/121.5.889 ER -