Autoreactivity in Human IgG+ Memory B Cells Export

@article{citeulike:2808218, abstract = {More than half of the nascent B cells in humans initially express autoreactive antibodies. However, most of these autoantibodies are removed from the repertoire at two checkpoints before maturation into naive B cells. A third checkpoint excludes remaining autoantibodies from the antigen-experienced IgM(+) memory B cell pool. Nevertheless, low-affinity self-reactive antibodies are frequently found in the serum of normal humans. To determine the source of these antibodies, we cloned and expressed antibodies from circulating human IgG(+) memory B cells. Surprisingly, we found that self-reactive antibodies including anti-nuclear antibodies were frequently expressed by IgG(+) memory B cells in healthy donors. Most of these antibodies were created de novo by somatic hypermutation during the transition between mature naive and IgG(+) memory B cells. We conclude that deregulation of self-reactive IgG(+) memory B cells may be associated with autoimmunity.}, address = {Max-Planck-Institute for Infection Biology, D-10117 Berlin, Germany.}, author = {Tiller, Thomas and Tsuiji, Makoto and Yurasov, Sergey and Velinzon, Klara and Nussenzweig, Michel C. and Wardemann, Hedda}, citeulike-article-id = {2808218}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.immuni.2007.01.009}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S1074761307001367}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17306569}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17306569}, day = {23}, doi = {10.1016/j.immuni.2007.01.009}, issn = {10747613}, journal = {Immunity}, keywords = {autoreactive, igg}, month = {February}, number = {2}, pages = {205--213}, posted-at = {2008-05-17 20:52:25}, priority = {2}, title = {Autoreactivity in Human IgG+ Memory B Cells}, url = {http://dx.doi.org/10.1016/j.immuni.2007.01.009}, volume = {26}, year = {2007} }

TY - JOUR ID - citeulike:2808218 L3 - citeulike-article-id:2808218 N2 - More than half of the nascent B cells in humans initially express autoreactive antibodies. However, most of these autoantibodies are removed from the repertoire at two checkpoints before maturation into naive B cells. A third checkpoint excludes remaining autoantibodies from the antigen-experienced IgM(+) memory B cell pool. Nevertheless, low-affinity self-reactive antibodies are frequently found in the serum of normal humans. To determine the source of these antibodies, we cloned and expressed antibodies from circulating human IgG(+) memory B cells. Surprisingly, we found that self-reactive antibodies including anti-nuclear antibodies were frequently expressed by IgG(+) memory B cells in healthy donors. Most of these antibodies were created de novo by somatic hypermutation during the transition between mature naive and IgG(+) memory B cells. We conclude that deregulation of self-reactive IgG(+) memory B cells may be associated with autoimmunity. IS - 2 JF - Immunity SN - 10747613 AD - Max-Planck-Institute for Infection Biology, D-10117 Berlin, Germany. EP - 213 TI - Autoreactivity in Human IgG+ Memory B Cells VL - 26 SP - 205 KW - autoreactive KW - igg AU - Tiller, Thomas AU - Tsuiji, Makoto AU - Yurasov, Sergey AU - Velinzon, Klara AU - Nussenzweig, Michel AU - Wardemann, Hedda PY - 2007/02/23/ UR - http://dx.doi.org/10.1016/j.immuni.2007.01.009 ER -