Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef. Export

@article{citeulike:679177, abstract = {Cytotoxic T-lymphocyte (CTL) responses to human immunodeficiency virus arise early after infection, but ultimately fail to prevent progression to AIDS. Human immunodeficiency virus may evade the CTL response by accumulating amino-acid replacements within CTL epitopes. We studied 10 CTL epitopes during the course of simian immunodeficiency virus disease progression in three related macaques. All 10 of these CTL epitopes accumulated amino-acid replacements and showed evidence of positive selection by the time the macaques died. Many of the amino-acid replacements in these epitopes reduced or eliminated major histocompatibility complex class I binding and/or CTL recognition. These findings strongly support the CTL 'escape' hypothesis.}, address = {Wisconsin Regional Primate Research Center, University of Wisconsin, 1220 Capitol Court, Madison, Wisconsin 53715, USA.}, author = {Evans, D. T. and O'Connor, D. H. and Jing, P. and Dzuris, J. L. and Sidney, J. and da Silva, J. and Allen, T. M. and Horton, H. and Venham, J. E. and Rudersdorf, R. A. and Vogel, T. and Pauza, C. D. and Bontrop, R. E. and DeMars, R. and Sette, A. and Hughes, A. L. and Watkins, D. I.}, citeulike-article-id = {679177}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/15224}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/10545993}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=10545993}, doi = {10.1038/15224}, issn = {1078-8956}, journal = {Nat Med}, keywords = {acid, amino, hiv, selection}, month = {November}, number = {11}, pages = {1270--1276}, posted-at = {2006-06-01 06:27:13}, priority = {2}, title = {Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef.}, url = {http://dx.doi.org/10.1038/15224}, volume = {5}, year = {1999} }

TY - JOUR ID - citeulike:679177 L3 - citeulike-article-id:679177 N2 - Cytotoxic T-lymphocyte (CTL) responses to human immunodeficiency virus arise early after infection, but ultimately fail to prevent progression to AIDS. Human immunodeficiency virus may evade the CTL response by accumulating amino-acid replacements within CTL epitopes. We studied 10 CTL epitopes during the course of simian immunodeficiency virus disease progression in three related macaques. All 10 of these CTL epitopes accumulated amino-acid replacements and showed evidence of positive selection by the time the macaques died. Many of the amino-acid replacements in these epitopes reduced or eliminated major histocompatibility complex class I binding and/or CTL recognition. These findings strongly support the CTL 'escape' hypothesis. IS - 11 JF - Nat Med SN - 1078-8956 AD - Wisconsin Regional Primate Research Center, University of Wisconsin, 1220 Capitol Court, Madison, Wisconsin 53715, USA. EP - 1276 TI - Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef. VL - 5 SP - 1270 KW - acid KW - amino KW - hiv KW - selection AU - Evans, DT AU - O'Connor, DH AU - Jing, P AU - Dzuris, JL AU - Sidney, J AU - da Silva, J AU - Allen, TM AU - Horton, H AU - Venham, JE AU - Rudersdorf, RA AU - Vogel, T AU - Pauza, CD AU - Bontrop, RE AU - DeMars, R AU - Sette, A AU - Hughes, AL AU - Watkins, DI PY - 1999/11// UR - http://dx.doi.org/10.1038/15224 ER -