Virulence differences between monkeypox virus isolates from West Africa and the Congo basin. Export

@article{citeulike:977066, abstract = {Studies indicate that West African and Congo basin isolates of monkeypox virus (MPXV) are genetically distinct. Here, we show Congo basin MPXV-ZAI-V79 is more virulent for cynomolgus monkeys as compared to presumed West African MPXV-COP-58. This finding may explain the lack of case-fatalities in the U.S. 2003 monkeypox outbreak, which was caused by a West African virus. Virulence differences between West African and Congo basin MPXV are further supported by epidemiological analyses that observed a similar prevalence of antibodies in non-vaccinated humans in both regions, while >90\% of reported cases occurred in the Congo basin, and no fatal cases were observed outside of this region. To determine the basis for this difference in virulence, we sequenced the genomes of one human West African isolate, and two presumed West African isolates and compared the sequences to Congo basin MPXV-ZAI-96-I-16. The analysis identified D10L, D14L, B10R, B14R, and B19R as possible virulence genes, with D14L (ortholog of vaccinia complement protein) as a leading candidate.}, address = {Department of Molecular Microbiology and Immunology, Saint Louis University Health Sciences Center, M432, St. Louis, MO 63104, USA.}, author = {Chen, N. and Li, G. and Liszewski, M. K. and Atkinson, J. P. and Jahrling, P. B. and Feng, Z. and Schriewer, J. and Buck, C. and Wang, C. and Lefkowitz, E. J. and Esposito, J. J. and Harms, T. and Damon, I. K. and Roper, R. L. and Upton, C. and Buller, R. M.}, citeulike-article-id = {977066}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.virol.2005.05.030}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16023693}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16023693}, doi = {10.1016/j.virol.2005.05.030}, issn = {0042-6822}, journal = {Virology}, keywords = {ecu, immunology}, month = {September}, number = {1}, pages = {46--63}, posted-at = {2006-12-06 20:14:15}, priority = {2}, title = {Virulence differences between monkeypox virus isolates from West Africa and the Congo basin.}, url = {http://dx.doi.org/10.1016/j.virol.2005.05.030}, volume = {340}, year = {2005} }

TY - JOUR ID - citeulike:977066 L3 - citeulike-article-id:977066 N2 - Studies indicate that West African and Congo basin isolates of monkeypox virus (MPXV) are genetically distinct. Here, we show Congo basin MPXV-ZAI-V79 is more virulent for cynomolgus monkeys as compared to presumed West African MPXV-COP-58. This finding may explain the lack of case-fatalities in the U.S. 2003 monkeypox outbreak, which was caused by a West African virus. Virulence differences between West African and Congo basin MPXV are further supported by epidemiological analyses that observed a similar prevalence of antibodies in non-vaccinated humans in both regions, while >90% of reported cases occurred in the Congo basin, and no fatal cases were observed outside of this region. To determine the basis for this difference in virulence, we sequenced the genomes of one human West African isolate, and two presumed West African isolates and compared the sequences to Congo basin MPXV-ZAI-96-I-16. The analysis identified D10L, D14L, B10R, B14R, and B19R as possible virulence genes, with D14L (ortholog of vaccinia complement protein) as a leading candidate. IS - 1 JF - Virology SN - 0042-6822 AD - Department of Molecular Microbiology and Immunology, Saint Louis University Health Sciences Center, M432, St. Louis, MO 63104, USA. EP - 63 TI - Virulence differences between monkeypox virus isolates from West Africa and the Congo basin. VL - 340 SP - 46 KW - ecu KW - immunology AU - Chen, N AU - Li, G AU - Liszewski, MK AU - Atkinson, JP AU - Jahrling, PB AU - Feng, Z AU - Schriewer, J AU - Buck, C AU - Wang, C AU - Lefkowitz, EJ AU - Esposito, JJ AU - Harms, T AU - Damon, IK AU - Roper, RL AU - Upton, C AU - Buller, RM PY - 2005/09/15/ UR - http://dx.doi.org/10.1016/j.virol.2005.05.030 ER -