Chemoenzymatic Synthesis of Rivastigmine Based on Lipase-Catalyzed Processes Export

@article{citeulike:5321038, abstract = {PMID: 19555095 A straightforward chemoenzymatic synthesis of enantiomerically pure rivastigmine has been efficiently carried out under mild reaction conditions, with Candida antarctica lipase B responsible for the stereoselective acetylation of the corresponding (R)-alcohol or amine. An exhaustive enzymatic study has been developed exploring the possibilities of carry out enzyme recycling, scaling up the enzymatic process and development of a dynamic kinetic resolution procedure for the production of adequate enantiomerically pure precursors of rivastigmine. Total chemoenzymatic synthesis of this pharmaceutical has been performed in good overall yield from commercially available 3-methoxyacetophenone.}, author = {Mangas-Sánchez, Juan and Rodríguez-Mata, María and Busto, Eduardo and Gotor-Fernández, Vicente and Gotor, Vicente}, citeulike-article-id = {5321038}, citeulike-linkout-0 = {http://dx.doi.org/10.1021/jo900784g}, citeulike-linkout-1 = {http://pubs.acs.org/doi/abs/10.1021/jo900784g}, day = {7}, doi = {10.1021/jo900784g}, journal = {The Journal of Organic Chemistry}, keywords = {cal-b, vip}, month = {August}, number = {15}, pages = {5304--5310}, posted-at = {2009-08-01 14:49:57}, priority = {2}, title = {Chemoenzymatic Synthesis of Rivastigmine Based on Lipase-Catalyzed Processes}, url = {http://dx.doi.org/10.1021/jo900784g}, volume = {74}, year = {2009} }

TY - JOUR ID - citeulike:5321038 L3 - citeulike-article-id:5321038 N2 - PMID: 19555095 A straightforward chemoenzymatic synthesis of enantiomerically pure rivastigmine has been efficiently carried out under mild reaction conditions, with Candida antarctica lipase B responsible for the stereoselective acetylation of the corresponding (R)-alcohol or amine. An exhaustive enzymatic study has been developed exploring the possibilities of carry out enzyme recycling, scaling up the enzymatic process and development of a dynamic kinetic resolution procedure for the production of adequate enantiomerically pure precursors of rivastigmine. Total chemoenzymatic synthesis of this pharmaceutical has been performed in good overall yield from commercially available 3-methoxyacetophenone. IS - 15 JF - The Journal of Organic Chemistry EP - 5310 TI - Chemoenzymatic Synthesis of Rivastigmine Based on Lipase-Catalyzed Processes VL - 74 SP - 5304 KW - cal-b KW - vip AU - Mangas-Sánchez, Juan AU - Rodríguez-Mata, María AU - Busto, Eduardo AU - Gotor-Fernández, Vicente AU - Gotor, Vicente PY - 2009/08/07/ UR - http://dx.doi.org/10.1021/jo900784g ER -