Relationship between respiration, end-tidal CO2, and BOLD signals in resting-state fMRI Export

@article{citeulike:4385922, abstract = {A significant component of BOLD fMRI physiological noise is caused by variations in the depth and rate of respiration. It has previously been demonstrated that a breath-to-breath metric of respiratory variation (respiratory volume per time; RVT), computed from pneumatic belt measurements of chest expansion, has a strong linear relationship with resting-state BOLD signals across the brain. RVT is believed to capture breathing-induced changes in arterial CO 2 , which is a cerebral vasodilator; indeed, separate studies have found that spontaneous fluctuations in end-tidal CO 2 (PETCO 2 ) are correlated with BOLD signal time series. The present study quantifies the degree to which RVT and PETCO 2 measurements relate to one another and explain common aspects of the resting-state BOLD signal. It is found that RVT (particularly when convolved with a particular impulse response, the ” respiration response function”) is highly correlated with PETCO 2 , and that both explain remarkably similar spatial and temporal BOLD signal variance across the brain. In addition, end-tidal O 2 is shown to be largely redundant with PETCO 2 . Finally, the latency at which PETCO 2 and respiration belt measures are correlated with the time series of individual voxels is found to vary across the brain and may reveal properties of intrinsic vascular response delays.}, author = {Chang, Catie and Glover, Gary H.}, citeulike-article-id = {4385922}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.neuroimage.2009.04.048}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S1053811909004121}, day = {01}, doi = {10.1016/j.neuroimage.2009.04.048}, issn = {10538119}, journal = {NeuroImage}, keywords = {activation, bold, co2, resting, state}, month = {October}, number = {4}, pages = {1381--1393}, posted-at = {2009-10-23 12:01:23}, priority = {2}, title = {Relationship between respiration, end-tidal CO2, and BOLD signals in resting-state fMRI}, url = {http://dx.doi.org/10.1016/j.neuroimage.2009.04.048}, volume = {47}, year = {2009} }

TY - JOUR ID - citeulike:4385922 L3 - citeulike-article-id:4385922 N2 - A significant component of BOLD fMRI physiological noise is caused by variations in the depth and rate of respiration. It has previously been demonstrated that a breath-to-breath metric of respiratory variation (respiratory volume per time; RVT), computed from pneumatic belt measurements of chest expansion, has a strong linear relationship with resting-state BOLD signals across the brain. RVT is believed to capture breathing-induced changes in arterial CO 2 , which is a cerebral vasodilator; indeed, separate studies have found that spontaneous fluctuations in end-tidal CO 2 (PETCO 2 ) are correlated with BOLD signal time series. The present study quantifies the degree to which RVT and PETCO 2 measurements relate to one another and explain common aspects of the resting-state BOLD signal. It is found that RVT (particularly when convolved with a particular impulse response, the “respiration response function”) is highly correlated with PETCO 2 , and that both explain remarkably similar spatial and temporal BOLD signal variance across the brain. In addition, end-tidal O 2 is shown to be largely redundant with PETCO 2 . Finally, the latency at which PETCO 2 and respiration belt measures are correlated with the time series of individual voxels is found to vary across the brain and may reveal properties of intrinsic vascular response delays. IS - 4 JF - NeuroImage SN - 10538119 EP - 1393 TI - Relationship between respiration, end-tidal CO2, and BOLD signals in resting-state fMRI VL - 47 SP - 1381 KW - activation KW - bold KW - co2 KW - resting KW - state AU - Chang, Catie AU - Glover, Gary PY - 2009/10/01/ UR - http://dx.doi.org/10.1016/j.neuroimage.2009.04.048 ER -