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What Is Your Diagnosis?by: Kelley M. Thieman, Jill Clark, Philip J. Johnson, Stephanie Essman, Elizabeth A. Giuliano, Jeff Mitchell
Journal of the American Veterinary Medical Association, Vol. 230, No. 4. (15 February 2007), pp. 509-510.
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AbstractA 4-month-old female American Saddlebred was referred for increased respiratory effort, lethargy, inappetance, weight loss, and insufficient growth of 4 weeks’ duration. Neither coughing nor nasal discharge had been observed. Clinical signs had become worse despite treatment with ceftiofur sodium. On admission, the foal was moderately thin, lethargic, 5% to 6% dehydrated, tachypneic (respiratory rate, 49 breaths/min; reference range, 10 to 30 breaths/min), tachycardic (156 beats/min; reference range, 30 to 45 beats/min), and febrile (40.2oC [104.3oF]; reference range, 37.5o to 39.0oC [99o to 102oF]) and had pale mucous membranes, and its respiratory effort was increased. Normal breath sounds were detected during auscultation of the lungs; however, adventitious breath sounds were not detected. Both eyes were affected with severe uveitis, and the conjunctival mucosae were characterized by petechial hemorrhages. Moderate effusion was detected in both tibiotarsal joints, but no signs of pain or lameness were evident. Results of a CBC included anemia (PCV, 11%; reference range, 32% to 45%) and neutrophilia (17.7 X 103 cells/ μL; reference range, 5.4 to 14.3 X 103 cells/μL) with a degenerative left shift (band neutrophils, 0.35 X 103 cells/μL; reference range, 0 to 0.1 X 103 cells/μL), and mild toxic changes were detected in the neutrophils. Abnormalities detected on serum biochemical analysis included hypoglycemia (glucose, 66 mg/dL; reference range, 83 to 113 mg/dL); azotemia (urea nitrogen, 55 mg/dL; reference range, 8 to 23 mg/dL); hypoalbuminemia (1.4 g/dL; reference range, 3.5 to 4.4 g/dL); high anion gap (22 mEq/L; reference range, 8 to 16 mEq/L); and low bicarbonate concentra- tion (10 mEq/L; reference range, 26 to 35 mEq/L), compatible with metabolic acidosis. A blood sample obtained aseptically was submitted for bacteriologic culture. No abnormalities were detected on radiography of the thorax. Ultrasonography of the abdomen was performed (Figure 1).
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