Single-slice dynamic computed tomographic determination of glomerular filtration rate by use of Patlak plot analysis in anesthetized pigs Export

@article{citeulike:1142112, abstract = {Objective—To compare glomerular filtration rate (GFR) as estimated from Patlak plot analysis by use of single-slice computed tomography (CT) with that obtained from clearance of plasma inulin in pigs. Animals—8 healthy anesthetized juvenile pigs. Procedures—All pigs underwent precontrast, whole-kidney, helical CT; postcontrast single-slice dynamic CT; and postcontrast, whole-kidney CT for volume determination. On dynamic images, corrected Hounsfield unit values were determined for each kidney and the aorta. A Patlak plot for each kidney was generated, and plasma clearance per unit volume was multiplied by renal volume to obtain whole-animal contrast clearance. Mean GFR determined via inulin clearance (Inu-GFR) was measured from each kidney and correlated to mean GFR determined via CT (CT-GFR) for the left kidney, right kidney, and both kidneys by use of linear regression and Bland-Altman analyses. Results—CT-GFR results from 7 pigs were valid. Total and right kidney Inu-GFR were correlated with total and right kidney CT-GFR (total, R2 = 0.85; right kidney, R2 = 0.86). However, left kidney CT-GFR was poorly correlated with left kidney Inu-GFR (R2 = 0.47). Bland-Altman analysis revealed no significant bias between Inu-GFR and CT-GFR for the left kidney, right kidney, or both kidneys. Conclusions and Clinical Relevance—CT-GFR as determined by use of a single-slice acquisition technique, low-dose of iohexol, and Patlak plot analysis correlated without bias with Inu-GFR for the right kidney and both kidneys (combined). This technique has promise as an accurate CT-GFR method that can be combined with renal morphologic evaluation.}, author = {Alexander, Kate and Del and Ybarra, Norma and Morin, Valerie and Gauvin, Domianique and Authier, Simon and Vinay, Patrick and Troncy, Eric}, citeulike-article-id = {1142112}, journal = {American Journal of Veterinary Research}, keywords = {ct, dynamic, gfr}, month = {March}, number = {3}, pages = {297--304}, posted-at = {2007-03-05 18:57:36}, priority = {4}, title = {Single-slice dynamic computed tomographic determination of glomerular filtration rate by use of Patlak plot analysis in anesthetized pigs}, volume = {68}, year = {2007} }

TY - JOUR ID - citeulike:1142112 L3 - citeulike-article-id:1142112 N2 - Objective—To compare glomerular filtration rate (GFR) as estimated from Patlak plot analysis by use of single-slice computed tomography (CT) with that obtained from clearance of plasma inulin in pigs. Animals—8 healthy anesthetized juvenile pigs. Procedures—All pigs underwent precontrast, whole-kidney, helical CT; postcontrast single-slice dynamic CT; and postcontrast, whole-kidney CT for volume determination. On dynamic images, corrected Hounsfield unit values were determined for each kidney and the aorta. A Patlak plot for each kidney was generated, and plasma clearance per unit volume was multiplied by renal volume to obtain whole-animal contrast clearance. Mean GFR determined via inulin clearance (Inu-GFR) was measured from each kidney and correlated to mean GFR determined via CT (CT-GFR) for the left kidney, right kidney, and both kidneys by use of linear regression and Bland-Altman analyses. Results—CT-GFR results from 7 pigs were valid. Total and right kidney Inu-GFR were correlated with total and right kidney CT-GFR (total, R2 = 0.85; right kidney, R2 = 0.86). However, left kidney CT-GFR was poorly correlated with left kidney Inu-GFR (R2 = 0.47). Bland-Altman analysis revealed no significant bias between Inu-GFR and CT-GFR for the left kidney, right kidney, or both kidneys. Conclusions and Clinical Relevance—CT-GFR as determined by use of a single-slice acquisition technique, low-dose of iohexol, and Patlak plot analysis correlated without bias with Inu-GFR for the right kidney and both kidneys (combined). This technique has promise as an accurate CT-GFR method that can be combined with renal morphologic evaluation. IS - 3 JF - American Journal of Veterinary Research EP - 304 TI - Single-slice dynamic computed tomographic determination of glomerular filtration rate by use of Patlak plot analysis in anesthetized pigs VL - 68 SP - 297 KW - ct KW - dynamic KW - gfr AU - Alexander, Kate AU - Del AU - Ybarra, Norma AU - Morin, Valerie AU - Gauvin, Domianique AU - Authier, Simon AU - Vinay, Patrick AU - Troncy, Eric PY - 2007/03// ER -