Ultrasound-guided cytology of spleen and liver: a prognostic tool in canine cutaneous mast cell tumor. Export

@article{citeulike:5492297, abstract = {BACKGROUND: In the clinical staging of cutaneous mast cell tumors (cMCT), the diagnosis of metastasis is controversial based on cytological examination of lymph nodes, spleen, liver, bone marrow, and blood. OBJECTIVES: To define the prognostic role of ultrasound-guided cytology of spleen and liver in cMCT. The results of cytological evaluation were compared in relation with survival time. ANIMALS: Fifty-two client-owned dogs with a diagnosis of cMCT. METHODS: Selection of cases was based on cytological evaluation of liver and spleen to detect infiltration at distant sites. The Kaplan Meier method was used to compare survival in dogs with and without infiltration of spleen and liver (log-rank test P < .05). RESULTS: Ten dogs with cMCT had mast cell infiltration of spleen, liver, or both and 4 of these dogs had involvement of the regional lymph nodes. The majority of dogs had 2 or more ultrasonographically abnormal findings simultaneously in spleen and liver. Nine dogs had grade II cMCT, and 1 had grade III cMCT. Dogs with positive evidence of mast cell infiltration to spleen, liver, or both had shorter survival times (34 versus 733 days) compared with dogs negative for mast cell infiltration at distant sites. CONCLUSION AND CLINICAL IMPORTANCE: Dogs with evidence of mast cell infiltration at distant sites have a shorter survival times than dogs without evidence of infiltration at distant sites. This study suggests that cytology of spleen and liver is indicated either for ultrasonographically normal or for ultrasonographically abnormal spleen and liver in dogs with cMCT.}, address = {Dipartimenti di Scienze Cliniche Veterinarie, Facolt di Medicina Veterinaria, Universit degli Studi di Milano, Milano, Italia; Patologia Animale, Igiene e Sanit Pubblica, Facolt di Medicina Veterinaria, Universit degli Studi di Milano, Milano, Italia.}, author = {Stefanello, D. and Valenti, P. and Faverzani, S. and Bronzo, V. and Fiorbianco, V. and Pinto da Cunha, N. and Romussi, S. and Cantatore, M. and Caniatti, M.}, citeulike-article-id = {5492297}, citeulike-linkout-0 = {http://dx.doi.org/10.1111/j.1939-1676.2009.0354.x}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19656285}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19656285}, citeulike-linkout-3 = {http://www3.interscience.wiley.com/cgi-bin/abstract/122523676/ABSTRACT}, day = {28}, doi = {10.1111/j.1939-1676.2009.0354.x}, issn = {0891-6640}, journal = {Journal of veterinary internal medicine / American College of Veterinary Internal Medicine}, keywords = {canine, cell, cytology, liver, mast, spleen, tumor, ultrasound}, month = {July}, number = {5}, pages = {1051--1057}, posted-at = {2009-08-20 18:49:10}, priority = {2}, title = {Ultrasound-guided cytology of spleen and liver: a prognostic tool in canine cutaneous mast cell tumor.}, url = {http://dx.doi.org/10.1111/j.1939-1676.2009.0354.x}, volume = {23}, year = {2009} }

TY - JOUR ID - citeulike:5492297 L3 - citeulike-article-id:5492297 N2 - BACKGROUND: In the clinical staging of cutaneous mast cell tumors (cMCT), the diagnosis of metastasis is controversial based on cytological examination of lymph nodes, spleen, liver, bone marrow, and blood. OBJECTIVES: To define the prognostic role of ultrasound-guided cytology of spleen and liver in cMCT. The results of cytological evaluation were compared in relation with survival time. ANIMALS: Fifty-two client-owned dogs with a diagnosis of cMCT. METHODS: Selection of cases was based on cytological evaluation of liver and spleen to detect infiltration at distant sites. The Kaplan Meier method was used to compare survival in dogs with and without infiltration of spleen and liver (log-rank test P < .05). RESULTS: Ten dogs with cMCT had mast cell infiltration of spleen, liver, or both and 4 of these dogs had involvement of the regional lymph nodes. The majority of dogs had 2 or more ultrasonographically abnormal findings simultaneously in spleen and liver. Nine dogs had grade II cMCT, and 1 had grade III cMCT. Dogs with positive evidence of mast cell infiltration to spleen, liver, or both had shorter survival times (34 versus 733 days) compared with dogs negative for mast cell infiltration at distant sites. CONCLUSION AND CLINICAL IMPORTANCE: Dogs with evidence of mast cell infiltration at distant sites have a shorter survival times than dogs without evidence of infiltration at distant sites. This study suggests that cytology of spleen and liver is indicated either for ultrasonographically normal or for ultrasonographically abnormal spleen and liver in dogs with cMCT. IS - 5 JF - Journal of veterinary internal medicine / American College of Veterinary Internal Medicine SN - 0891-6640 AD - Dipartimenti di Scienze Cliniche Veterinarie, Facolt di Medicina Veterinaria, Universit degli Studi di Milano, Milano, Italia; Patologia Animale, Igiene e Sanit Pubblica, Facolt di Medicina Veterinaria, Universit degli Studi di Milano, Milano, Italia. EP - 1057 TI - Ultrasound-guided cytology of spleen and liver: a prognostic tool in canine cutaneous mast cell tumor. VL - 23 SP - 1051 KW - canine KW - cell KW - cytology KW - liver KW - mast KW - spleen KW - tumor KW - ultrasound AU - Stefanello, D AU - Valenti, P AU - Faverzani, S AU - Bronzo, V AU - Fiorbianco, V AU - Pinto da Cunha, N AU - Romussi, S AU - Cantatore, M AU - Caniatti, M PY - 2009/07/28/t UR - http://dx.doi.org/10.1111/j.1939-1676.2009.0354.x ER -