Light-Controlled Molecular Shuttles Made from Motor Proteins Carrying Cargo on Engineered Surfaces Export

@article{citeulike:1039215, abstract = {Molecular shuttles have been built from motor proteins capable of moving cargo along engineered paths. We illustrate alternative methods of controlling the direction of motion of microtubules on engineered kinesin tracks, how to load cargo covalently to microtubules, and how to exploit UV-induced release of caged ATP combined with enzymatic ATP degradation by hexokinase to turn the shuttles on and off sequentially. These are the first steps in the development of a tool kit to utilize molecular motors for the construction of nanoscale assembly lines.}, address = {Department of Bioengineering, University of Washington, Seattle Washington 98195, and Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany}, author = {Hess, Henry and Clemmens, John and Qin, Dong and Howard, Jonathon and Vogel, Viola}, citeulike-article-id = {1039215}, citeulike-linkout-0 = {http://dx.doi.org/10.1021/nl015521e}, citeulike-linkout-1 = {http://pubs.acs.org/doi/abs/10.1021/nl015521e}, day = {1}, doi = {10.1021/nl015521e}, journal = {Nano Letters}, keywords = {atp, caged, motors}, month = {May}, number = {5}, pages = {235--239}, posted-at = {2009-09-15 00:09:51}, priority = {2}, title = {Light-Controlled Molecular Shuttles Made from Motor Proteins Carrying Cargo on Engineered Surfaces}, url = {http://dx.doi.org/10.1021/nl015521e}, volume = {1}, year = {2001} }

TY - JOUR ID - citeulike:1039215 L3 - citeulike-article-id:1039215 N2 - Molecular shuttles have been built from motor proteins capable of moving cargo along engineered paths. We illustrate alternative methods of controlling the direction of motion of microtubules on engineered kinesin tracks, how to load cargo covalently to microtubules, and how to exploit UV-induced release of caged ATP combined with enzymatic ATP degradation by hexokinase to turn the shuttles on and off sequentially. These are the first steps in the development of a tool kit to utilize molecular motors for the construction of nanoscale assembly lines. IS - 5 JF - Nano Letters AD - Department of Bioengineering, University of Washington, Seattle Washington 98195, and Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany EP - 239 TI - Light-Controlled Molecular Shuttles Made from Motor Proteins Carrying Cargo on Engineered Surfaces VL - 1 SP - 235 KW - atp KW - caged KW - motors AU - Hess, Henry AU - Clemmens, John AU - Qin, Dong AU - Howard, Jonathon AU - Vogel, Viola PY - 2001/05/01/ UR - http://dx.doi.org/10.1021/nl015521e ER -