Non-B DNA structure-induced genetic instability and evolution. Export

@article{citeulike:5724113, abstract = {Repetitive DNA motifs are abundant in the genomes of various species and have the capacity to adopt non-canonical (i.e., non-B) DNA structures. Several non-B DNA structures, including cruciforms, slipped structures, triplexes, G-quadruplexes, and Z-DNA, have been shown to cause mutations, such as deletions, expansions, and translocations in both prokaryotes and eukaryotes. Their distributions in genomes are not random and often co-localize with sites of chromosomal breakage associated with genetic diseases. Current genome-wide sequence analyses suggest that the genomic instabilities induced by non-B DNA structure-forming sequences not only result in predisposition to disease, but also contribute to rapid evolutionary changes, particularly in genes associated with development and regulatory functions. In this review, we describe the occurrence of non-B DNA-forming sequences in various species, the classes of genes enriched in non-B DNA-forming sequences, and recent mechanistic studies on DNA structure-induced genomic instability to highlight their importance in genomes.}, author = {Zhao, Junhua and Bacolla, Albino and Wang, Guliang and Vasquez, Karen M.}, citeulike-article-id = {5724113}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/s00018-009-0131-2}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19727556}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19727556}, day = {1}, doi = {10.1007/s00018-009-0131-2}, issn = {1420-9071}, journal = {Cellular and molecular life sciences : CMLS}, keywords = {g-quadruplex, genetic\_instability, gq-ingenome, regulatory\_functions}, month = {September}, posted-at = {2009-09-04 17:14:50}, priority = {2}, title = {Non-B DNA structure-induced genetic instability and evolution.}, url = {http://dx.doi.org/10.1007/s00018-009-0131-2}, year = {2009} }

TY - JOUR ID - citeulike:5724113 L3 - citeulike-article-id:5724113 N2 - Repetitive DNA motifs are abundant in the genomes of various species and have the capacity to adopt non-canonical (i.e., non-B) DNA structures. Several non-B DNA structures, including cruciforms, slipped structures, triplexes, G-quadruplexes, and Z-DNA, have been shown to cause mutations, such as deletions, expansions, and translocations in both prokaryotes and eukaryotes. Their distributions in genomes are not random and often co-localize with sites of chromosomal breakage associated with genetic diseases. Current genome-wide sequence analyses suggest that the genomic instabilities induced by non-B DNA structure-forming sequences not only result in predisposition to disease, but also contribute to rapid evolutionary changes, particularly in genes associated with development and regulatory functions. In this review, we describe the occurrence of non-B DNA-forming sequences in various species, the classes of genes enriched in non-B DNA-forming sequences, and recent mechanistic studies on DNA structure-induced genomic instability to highlight their importance in genomes. JF - Cellular and molecular life sciences : CMLS SN - 1420-9071 TI - Non-B DNA structure-induced genetic instability and evolution. KW - g-quadruplex KW - genetic_instability KW - gq-ingenome KW - regulatory_functions AU - Zhao, Junhua AU - Bacolla, Albino AU - Wang, Guliang AU - Vasquez, Karen PY - 2009/09/01/ UR - http://dx.doi.org/10.1007/s00018-009-0131-2 ER -