Acoustic Oddball during NREM Sleep: A Combined EEG/fMRI Study Export

@article{citeulike:5695674, abstract = {Background A condition vital for the consolidation and maintenance of sleep is generally reduced responsiveness to external stimuli. Despite this, the sleeper maintains a level of stimulus processing that allows to respond to potentially dangerous environmental signals. The mechanisms that subserve these contradictory functions are only incompletely understood. Methodology/Principal Findings Using combined EEG/fMRI we investigated the neural substrate of sleep protection by applying an acoustic oddball paradigm during light NREM sleep. Further, we studied the role of evoked K-complexes (KCs), an electroencephalographic hallmark of NREM sleep with a still unknown role for sleep protection. Our main results were: (1) Other than in wakefulness, rare tones did not induce a blood oxygenation level dependent (BOLD) signal increase in the auditory pathway but a strong negative BOLD response in motor areas and the amygdala. (2) Stratification of rare tones by the presence of evoked KCs detected activation of the auditory cortex, hippocampus, superior and middle frontal gyri and posterior cingulate only for rare tones followed by a KC. (3) The typical high frontocentral EEG deflections of KCs were not paralleled by a BOLD equivalent. Conclusions/Significance We observed that rare tones lead to transient disengagement of motor and amygdala responses during light NREM sleep. We interpret this as a sleep protective mechanism to delimit motor responses and to reduce the sensitivity of the amygdala towards further incoming stimuli. Evoked KCs are suggested to originate from a brain state with relatively increased stimulus processing, revealing an activity pattern resembling novelty processing as previously reported during wakefulness. The KC itself is not reflected by increased metabolic demand in BOLD based imaging, arguing that evoked KCs result from increased neural synchronicity without altered metabolic demand.}, author = {Czisch, Michael and Wehrle, Renate and Stiegler, Andrea and Peters, Henning and Andrade, Katia and Holsboer, Florian and S\"{a}mann, Philipp G.}, citeulike-article-id = {5695674}, citeulike-linkout-0 = {http://dx.doi.org/10.1371/journal.pone.0006749}, day = {25}, doi = {10.1371/journal.pone.0006749}, journal = {PLoS ONE}, keywords = {activation, erp, oddball, sleep}, month = {August}, number = {8}, pages = {e6749+}, posted-at = {2009-09-01 08:49:29}, priority = {2}, publisher = {Public Library of Science}, title = {Acoustic Oddball during NREM Sleep: A Combined EEG/fMRI Study}, url = {http://dx.doi.org/10.1371/journal.pone.0006749}, volume = {4}, year = {2009} }

TY - JOUR ID - citeulike:5695674 L3 - citeulike-article-id:5695674 N2 - Background A condition vital for the consolidation and maintenance of sleep is generally reduced responsiveness to external stimuli. Despite this, the sleeper maintains a level of stimulus processing that allows to respond to potentially dangerous environmental signals. The mechanisms that subserve these contradictory functions are only incompletely understood. Methodology/Principal Findings Using combined EEG/fMRI we investigated the neural substrate of sleep protection by applying an acoustic oddball paradigm during light NREM sleep. Further, we studied the role of evoked K-complexes (KCs), an electroencephalographic hallmark of NREM sleep with a still unknown role for sleep protection. Our main results were: (1) Other than in wakefulness, rare tones did not induce a blood oxygenation level dependent (BOLD) signal increase in the auditory pathway but a strong negative BOLD response in motor areas and the amygdala. (2) Stratification of rare tones by the presence of evoked KCs detected activation of the auditory cortex, hippocampus, superior and middle frontal gyri and posterior cingulate only for rare tones followed by a KC. (3) The typical high frontocentral EEG deflections of KCs were not paralleled by a BOLD equivalent. Conclusions/Significance We observed that rare tones lead to transient disengagement of motor and amygdala responses during light NREM sleep. We interpret this as a sleep protective mechanism to delimit motor responses and to reduce the sensitivity of the amygdala towards further incoming stimuli. Evoked KCs are suggested to originate from a brain state with relatively increased stimulus processing, revealing an activity pattern resembling novelty processing as previously reported during wakefulness. The KC itself is not reflected by increased metabolic demand in BOLD based imaging, arguing that evoked KCs result from increased neural synchronicity without altered metabolic demand. IS - 8 JF - PLoS ONE TI - Acoustic Oddball during NREM Sleep: A Combined EEG/fMRI Study PB - Public Library of Science VL - 4 SP - e6749 KW - activation KW - erp KW - oddball KW - sleep AU - Czisch, Michael AU - Wehrle, Renate AU - Stiegler, Andrea AU - Peters, Henning AU - Andrade, Katia AU - Holsboer, Florian AU - Sämann, Philipp PY - 2009/08/25/ UR - http://dx.doi.org/10.1371/journal.pone.0006749 ER -