Use of genome-scale microbial models for metabolic engineering

by: Kiran R Patil, Mats Akesson, Jens Nielsen

Current Opinion in Biotechnology, Vol. 15, No. 1. (February 2004), pp. 64-69.

View FullText article

DOI, ScienceDirect

Reviews [Write a review of this article]

There are no reviews of this article

Find related articles from these CiteULike users

claire2327, JeremyZucker, streptomyces (group), MetabolicModeling (group)

Find related articles with these CiteULike tags

engineering, metabolic, metabolic-engineering, metabolic-reconstruction, mfa

Abstract

Metabolic engineering serves as an integrated approach to design new cell factories by providing rational design procedures and valuable mathematical and experimental tools. Mathematical models have an important role for phenotypic analysis, but can also be used for the design of optimal metabolic network structures. The major challenge for metabolic engineering in the post-genomic era is to broaden its design methodologies to incorporate genome-scale biological data. Genome-scale stoichiometric models of microorganisms represent a first step in this direction.

@article{citeulike:1243, abstract = {Metabolic engineering serves as an integrated approach to design new cell factories by providing rational design procedures and valuable mathematical and experimental tools. Mathematical models have an important role for phenotypic analysis, but can also be used for the design of optimal metabolic network structures. The major challenge for metabolic engineering in the post-genomic era is to broaden its design methodologies to incorporate genome-scale biological data. Genome-scale stoichiometric models of microorganisms represent a first step in this direction.}, author = {Patil, Kiran R. and Akesson, Mats and Nielsen, Jens }, citeulike-article-id = {1243}, doi = {10.1016/j.copbio.2003.11.003}, journal = {Current Opinion in Biotechnology}, keywords = {metabolic-reconstruction}, month = {February}, number = {1}, pages = {64--69}, posted-at = {2007-10-30 00:52:13}, priority = {2}, title = {Use of genome-scale microbial models for metabolic engineering}, url = {http://dx.doi.org/10.1016/j.copbio.2003.11.003}, volume = {15}, year = {2004} }

RIS record

TY - JOUR ID - citeulike:1243 L3 - citeulike-article-id:1243 TI - Use of genome-scale microbial models for metabolic engineering JF - Current Opinion in Biotechnology VL - 15 IS - 1 SP - 64 EP - 69 N2 - Metabolic engineering serves as an integrated approach to design new cell factories by providing rational design procedures and valuable mathematical and experimental tools. Mathematical models have an important role for phenotypic analysis, but can also be used for the design of optimal metabolic network structures. The major challenge for metabolic engineering in the post-genomic era is to broaden its design methodologies to incorporate genome-scale biological data. Genome-scale stoichiometric models of microorganisms represent a first step in this direction. KW - metabolic-reconstruction AU - Patil, Kiran AU - Akesson, Mats AU - Nielsen, Jens PY - 2004/02// UR - http://dx.doi.org/10.1016/j.copbio.2003.11.003 ER -

RIS BibTeX