The multiple nuclear functions of BRCA1: transcription, ubiquitination and DNA repair Export

@article{citeulike:2755177, abstract = {Interest in BRCA1 stems from its role as a tumour suppressor in breast and ovarian cancer. Intensive research in BRCA1 has revealed little about its specific role in cancer; rather, this protein has been implicated in a multitude of important cellular processes. The diverse biochemical activities of BRCA1 combine to protect the genome from damage. New data reveal that BRCA1 transcriptionally regulates some DNA-repair genes, and, in addition, new roles for BRCA1 have been identified in heterochromatin formation on the X chromosome, double-strand-break repair, and ubiquitination. These diverse activities of BRCA1 may be linked in a single pathway, or BRCA1 might function in multiple nuclear processes.}, author = {Starita, Lea M. and Parvin, Jeffrey D.}, citeulike-article-id = {2755177}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/S0955-0674(03)00042-5}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6VRW-489B4YG-1/1/b57fe3511d302d9511d1510d0b894abe}, doi = {10.1016/S0955-0674(03)00042-5}, journal = {Current Opinion in Cell Biology}, keywords = {brca1, damage, dna, repair, transcription}, month = {June}, number = {3}, pages = {345--350}, posted-at = {2008-05-05 06:08:58}, priority = {5}, title = {The multiple nuclear functions of BRCA1: transcription, ubiquitination and DNA repair}, url = {http://dx.doi.org/10.1016/S0955-0674(03)00042-5}, volume = {15}, year = {2003} }

TY - JOUR ID - citeulike:2755177 L3 - citeulike-article-id:2755177 N2 - Interest in BRCA1 stems from its role as a tumour suppressor in breast and ovarian cancer. Intensive research in BRCA1 has revealed little about its specific role in cancer; rather, this protein has been implicated in a multitude of important cellular processes. The diverse biochemical activities of BRCA1 combine to protect the genome from damage. New data reveal that BRCA1 transcriptionally regulates some DNA-repair genes, and, in addition, new roles for BRCA1 have been identified in heterochromatin formation on the X chromosome, double-strand-break repair, and ubiquitination. These diverse activities of BRCA1 may be linked in a single pathway, or BRCA1 might function in multiple nuclear processes. IS - 3 JF - Current Opinion in Cell Biology EP - 350 TI - The multiple nuclear functions of BRCA1: transcription, ubiquitination and DNA repair VL - 15 SP - 345 KW - brca1 KW - damage KW - dna KW - repair KW - transcription AU - Starita, Lea AU - Parvin, Jeffrey PY - 2003/06// UR - http://dx.doi.org/10.1016/S0955-0674(03)00042-5 ER -