Histone H2B ubiquitination: the cancer connection — Genes & Development Export

@article{citeulike:3906840, abstract = {Post-translational modifications of histones play a critical role in gene expression control. Ultimately, cancer is a disease of aberrant gene expression. Accordingly, several histone-modifying enzymes have been described as proto-oncogenes or tumor suppressors. Recent reports, including one from Shema and colleagues (pp. 2664– 2676) in the October 1, 2008, issue of Genes and Development, indicate that deregulation of histone H2B monoubiquitination may contribute to cancer development.}, author = {Espinosa, Joaqu\'{\i}n M.}, citeulike-article-id = {3906840}, citeulike-linkout-0 = {http://genesdev.cshlp.org.libproxy.unm.edu/content/22/20/2743.abstract}, comment = {commentary on an article in the same issue that I have not yet read. easy commentary to read, reviewing what was known mid-2008 about histone H2B-ubiquitylation and relation to up- and down-regulation of transcription. One of the human subunits of Bre1 (the E3 ligase), RNF20 appears to be a tumor supressor. While the corresponding de-ubiquitinase showed up as a strong oncogene in the paper He is talking about.}, journal = {Genes \& Development}, keywords = {bre1, breastcancer, cancer, h2bub, ppeb, transcription}, pages = {2743--2749}, posted-at = {2009-01-19 05:52:13}, priority = {0}, title = {Histone H2B ubiquitination: the cancer connection — Genes \& Development}, url = {http://genesdev.cshlp.org.libproxy.unm.edu/content/22/20/2743.abstract}, volume = {22}, year = {2008} }

TY - JOUR ID - citeulike:3906840 L3 - citeulike-article-id:3906840 N2 - Post-translational modifications of histones play a critical role in gene expression control. Ultimately, cancer is a disease of aberrant gene expression. Accordingly, several histone-modifying enzymes have been described as proto-oncogenes or tumor suppressors. Recent reports, including one from Shema and colleagues (pp. 2664– 2676) in the October 1, 2008, issue of Genes and Development, indicate that deregulation of histone H2B monoubiquitination may contribute to cancer development. JF - Genes & Development EP - 2749 TI - Histone H2B ubiquitination: the cancer connection — Genes & Development VL - 22 SP - 2743 KW - bre1 KW - breastcancer KW - cancer KW - h2bub KW - ppeb KW - transcription N1 - commentary on an article in the same issue that I have not yet read. easy commentary to read, reviewing what was known mid-2008 about histone H2B-ubiquitylation and relation to up- and down-regulation of transcription. One of the human subunits of Bre1 (the E3 ligase), RNF20 appears to be a tumor supressor. While the corresponding de-ubiquitinase showed up as a strong oncogene in the paper He is talking about. AU - Espinosa, Joaquín PY - 2008/// UR - http://genesdev.cshlp.org.libproxy.unm.edu/content/22/20/2743.abstract ER -