Effect of Poly(ethylene glycol) Length on the in Vivo Behavior of Coated Quantum Dots Export

@article{citeulike:4194886, abstract = {The use of nanoparticles, either for the delivery of drugs or for imaging contrast agents, or a combination of both (theranostics), is very appealing in biological and biomedical research. The design of high-quality NIR-emitting quantum dots (QDs), with outstanding optical properties in comparison to that of organic dyes, should lead to novel contrast agents with improved performance for optical and multimodal imaging. Moreover, these nanocrystals could also be used for exploring therapeutic applications, such as drug delivery or phototherapy. In this article, we report the coating of commercial ITK705-amino QDs with methoxy-terminated poly(ethylene glycol) (PEG) of different chain lengths. Homogeneous QD solutions that are stable over extended periods of time were prepared. The impact of the particle coating on their in vivo fate after tail IV injection was studied by fluorescence imaging. The speed of the first pass extraction of the coated QDs toward the liver decreased with the PEG length, whereas the hydrodynamic diameter of the particles was increased.}, author = {Daou, T. Jean and Li, Liang and Reiss, Peter and Josserand, Véronique and Texier, Isabelle}, citeulike-article-id = {4194886}, citeulike-linkout-0 = {http://dx.doi.org/10.1021/la8035083}, citeulike-linkout-1 = {http://pubs.acs.org/doi/abs/10.1021/la8035083}, day = {3}, doi = {10.1021/la8035083}, journal = {Langmuir}, keywords = {biodistribution, nanotech, toxicity}, month = {March}, number = {5}, pages = {3040--3044}, posted-at = {2009-03-19 12:11:13}, priority = {2}, title = {Effect of Poly(ethylene glycol) Length on the in Vivo Behavior of Coated Quantum Dots}, url = {http://dx.doi.org/10.1021/la8035083}, volume = {25}, year = {2009} }

TY - JOUR ID - citeulike:4194886 L3 - citeulike-article-id:4194886 N2 - The use of nanoparticles, either for the delivery of drugs or for imaging contrast agents, or a combination of both (theranostics), is very appealing in biological and biomedical research. The design of high-quality NIR-emitting quantum dots (QDs), with outstanding optical properties in comparison to that of organic dyes, should lead to novel contrast agents with improved performance for optical and multimodal imaging. Moreover, these nanocrystals could also be used for exploring therapeutic applications, such as drug delivery or phototherapy. In this article, we report the coating of commercial ITK705-amino QDs with methoxy-terminated poly(ethylene glycol) (PEG) of different chain lengths. Homogeneous QD solutions that are stable over extended periods of time were prepared. The impact of the particle coating on their in vivo fate after tail IV injection was studied by fluorescence imaging. The speed of the first pass extraction of the coated QDs toward the liver decreased with the PEG length, whereas the hydrodynamic diameter of the particles was increased. IS - 5 JF - Langmuir EP - 3044 TI - Effect of Poly(ethylene glycol) Length on the in Vivo Behavior of Coated Quantum Dots VL - 25 SP - 3040 KW - biodistribution KW - nanotech KW - toxicity AU - Daou, Jean AU - Li, Liang AU - Reiss, Peter AU - Josserand, Véronique AU - Texier, Isabelle PY - 2009/03/03/ UR - http://dx.doi.org/10.1021/la8035083 ER -