Facile, Efficient Approach to Accomplish Tunable Chemistries and Variable Biodistributions for Shell Cross-Linked Nanoparticles Export

@article{citeulike:4636843, abstract = {The in vivo behavior of shell cross-linked knedel-like (SCK) nanoparticles is shown to be tunable via a straightforward and versatile process that advances SCKs as attractive nanoscale carriers in the field of nanomedicine. Tuning of the pharmacokinetics was accomplished by grafting varied numbers of methoxy-terminated poly(ethylene glycol) (mPEG) chains to the amphiphilic block copolymer precursors, together with chelators for the radioactive tracer and therapeutic agent 64Cu, followed by self-assembly into block copolymer micelles and chemical cross-linking throughout the shell regions. 64Cu-radiolabeling was then performed to evaluate the SCKs in vivo by means of biodistribution experiments and positron emission tomography (PET). It was found that the blood retention of PEGylated SCKs could be tuned, depending on the mPEG grafting density and the nanoparticle surface properties. A semiquantitative model of the density of mPEG surface coverage as a function of in vivo behavior was applied to enhance the understanding of this system.}, author = {Sun, Guorong and Hagooly, Aviv and Xu, Jinqi and Nyström, Andreas M. and Li, Zicheng and Rossin, Raffaella and Moore, Dennis A. and Wooley, Karen L. and Welch, Michael J.}, citeulike-article-id = {4636843}, citeulike-linkout-0 = {http://dx.doi.org/10.1021/bm800246x}, citeulike-linkout-1 = {http://pubs.acs.org/doi/abs/10.1021/bm800246x}, day = {1}, doi = {10.1021/bm800246x}, journal = {Biomacromolecules}, keywords = {cancer, nanotech}, month = {July}, number = {7}, pages = {1997--2006}, posted-at = {2009-06-08 12:38:35}, priority = {2}, title = {Facile, Efficient Approach to Accomplish Tunable Chemistries and Variable Biodistributions for Shell Cross-Linked Nanoparticles}, url = {http://dx.doi.org/10.1021/bm800246x}, volume = {9}, year = {2008} }

TY - JOUR ID - citeulike:4636843 L3 - citeulike-article-id:4636843 N2 - The in vivo behavior of shell cross-linked knedel-like (SCK) nanoparticles is shown to be tunable via a straightforward and versatile process that advances SCKs as attractive nanoscale carriers in the field of nanomedicine. Tuning of the pharmacokinetics was accomplished by grafting varied numbers of methoxy-terminated poly(ethylene glycol) (mPEG) chains to the amphiphilic block copolymer precursors, together with chelators for the radioactive tracer and therapeutic agent 64Cu, followed by self-assembly into block copolymer micelles and chemical cross-linking throughout the shell regions. 64Cu-radiolabeling was then performed to evaluate the SCKs in vivo by means of biodistribution experiments and positron emission tomography (PET). It was found that the blood retention of PEGylated SCKs could be tuned, depending on the mPEG grafting density and the nanoparticle surface properties. A semiquantitative model of the density of mPEG surface coverage as a function of in vivo behavior was applied to enhance the understanding of this system. IS - 7 JF - Biomacromolecules EP - 2006 TI - Facile, Efficient Approach to Accomplish Tunable Chemistries and Variable Biodistributions for Shell Cross-Linked Nanoparticles VL - 9 SP - 1997 KW - cancer KW - nanotech AU - Sun, Guorong AU - Hagooly, Aviv AU - Xu, Jinqi AU - Nyström, Andreas AU - Li, Zicheng AU - Rossin, Raffaella AU - Moore, Dennis AU - Wooley, Karen AU - Welch, Michael PY - 2008/07/01/ UR - http://dx.doi.org/10.1021/bm800246x ER -