Improved paramagnetic chelate for molecular imaging with MRI Export

@article{citeulike:4775166, abstract = {The relaxivity and transmetallation of two lipophilic paramagnetic chelates incorporated onto perfluorocarbon nanoparticles, i.e., gadolinium-methoxy-tetraazacyclododecane-tetraacetic acid phosphatidylethanolamine (Gd-MeO-DOTA-PE) and gadolinium-methoxy-tetraazacyclododecane-tetraacetic acid triglycine phosphatidylethanolamine (Gd-MeO-DOTA-triglycine-PE (Gd-MeO-DOTA-triglycine-PE)), were compared to a prototypic gadolinium-diethylene-triamine-pentaacetic acid bis-oleate (Gd-DTPA-BOA) paramagnetic formulation. Nanoparticles with MeO-DOTA-based chelates demonstrated higher relaxivity (40\% higher for Gd-MeO-DOTA-PE and 55\% higher for Gd-MeO-DOTA-triglycine-PE) and less transmetallation than the original Gd-DTPA-BOA-based agent.}, author = {Winter, P. and Athey, P. and Kiefer, G. and Gulyas, G. and Frank, K. and Fuhrhop, R. and Robertson, D. and Wickline, S. and Lanza, G.}, citeulike-article-id = {4775166}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.jmmm.2005.01.062}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0304885305001307}, doi = {10.1016/j.jmmm.2005.01.062}, issn = {03048853}, journal = {Journal of Magnetism and Magnetic Materials}, keywords = {emulsions, imaging, nanotech, nmr, perfluorocarbons}, month = {May}, number = {1}, pages = {540--545}, posted-at = {2009-06-08 12:38:21}, priority = {2}, title = {Improved paramagnetic chelate for molecular imaging with MRI}, url = {http://dx.doi.org/10.1016/j.jmmm.2005.01.062}, volume = {293}, year = {2005} }

TY - JOUR ID - citeulike:4775166 L3 - citeulike-article-id:4775166 N2 - The relaxivity and transmetallation of two lipophilic paramagnetic chelates incorporated onto perfluorocarbon nanoparticles, i.e., gadolinium-methoxy-tetraazacyclododecane-tetraacetic acid phosphatidylethanolamine (Gd-MeO-DOTA-PE) and gadolinium-methoxy-tetraazacyclododecane-tetraacetic acid triglycine phosphatidylethanolamine (Gd-MeO-DOTA-triglycine-PE (Gd-MeO-DOTA-triglycine-PE)), were compared to a prototypic gadolinium-diethylene-triamine-pentaacetic acid bis-oleate (Gd-DTPA-BOA) paramagnetic formulation. Nanoparticles with MeO-DOTA-based chelates demonstrated higher relaxivity (40% higher for Gd-MeO-DOTA-PE and 55% higher for Gd-MeO-DOTA-triglycine-PE) and less transmetallation than the original Gd-DTPA-BOA-based agent. IS - 1 JF - Journal of Magnetism and Magnetic Materials SN - 03048853 EP - 545 TI - Improved paramagnetic chelate for molecular imaging with MRI VL - 293 SP - 540 KW - emulsions KW - imaging KW - nanotech KW - nmr KW - perfluorocarbons AU - Winter, P AU - Athey, P AU - Kiefer, G AU - Gulyas, G AU - Frank, K AU - Fuhrhop, R AU - Robertson, D AU - Wickline, S AU - Lanza, G PY - 2005/05// UR - http://dx.doi.org/10.1016/j.jmmm.2005.01.062 ER -