Bioeliminable Nanohydrogels for Drug Delivery Export

@article{citeulike:3728118, abstract = {doi: 10.1021/nl8017274 One of the most significant obstacles for systematic delivery of nanopayloads is the foreign particle clearance by the mononuclear phagocyte system (MPS). The majority of biocompatible nanopayloads with charged groups on their surface cannot fully evade the clearance by MPS during systemic circulation. For safe and effective targeted nanodrug delivery in vivo, we describe a novel approach for evading the macrophage clearance. We demonstrate that neutral and hydrophilic materials can effectively evade the macrophage uptake and also quickly degrade into bioeliminable fragments. We show that there is no opsonization effect and no toxic effect on living cells. In addition, the payloads are stable in an aqueous environment, and they can release drugs in a cellular environment. These results suggest that the unique properties of this kind of payloads may make them useful for designing new drug delivery systems.}, author = {Gao, De and Xu, Hao and Philbert, Martin A. and Kopelman, Raoul}, citeulike-article-id = {3728118}, citeulike-linkout-0 = {http://dx.doi.org/10.1021/nl8017274}, citeulike-linkout-1 = {http://pubs.acs.org/doi/abs/10.1021/nl8017274}, doi = {10.1021/nl8017274}, journal = {Nano Letters}, keywords = {bioeliminable, citedby, delivery, drug, hydrogel, nanoparticles}, month = {October}, number = {10}, pages = {3320--3324}, posted-at = {2008-11-29 19:59:30}, priority = {2}, title = {Bioeliminable Nanohydrogels for Drug Delivery}, url = {http://dx.doi.org/10.1021/nl8017274}, volume = {8}, year = {2008} }

TY - JOUR ID - citeulike:3728118 L3 - citeulike-article-id:3728118 N2 - doi: 10.1021/nl8017274 One of the most significant obstacles for systematic delivery of nanopayloads is the foreign particle clearance by the mononuclear phagocyte system (MPS). The majority of biocompatible nanopayloads with charged groups on their surface cannot fully evade the clearance by MPS during systemic circulation. For safe and effective targeted nanodrug delivery in vivo, we describe a novel approach for evading the macrophage clearance. We demonstrate that neutral and hydrophilic materials can effectively evade the macrophage uptake and also quickly degrade into bioeliminable fragments. We show that there is no opsonization effect and no toxic effect on living cells. In addition, the payloads are stable in an aqueous environment, and they can release drugs in a cellular environment. These results suggest that the unique properties of this kind of payloads may make them useful for designing new drug delivery systems. IS - 10 JF - Nano Letters EP - 3324 TI - Bioeliminable Nanohydrogels for Drug Delivery VL - 8 SP - 3320 KW - bioeliminable KW - citedby KW - delivery KW - drug KW - hydrogel KW - nanoparticles AU - Gao, De AU - Xu, Hao AU - Philbert, Martin AU - Kopelman, Raoul PY - 2008/10// UR - http://dx.doi.org/10.1021/nl8017274 ER -