Endothelial Cells Stimulate Self-Renewal and Expand Neurogenesis of Neural Stem Cells

by: Qin Shen, Susan K Goderie, Li Jin, Nithin Karanth, Yu Sun, Natalia Abramova, Peter Vincent, Kevin Pumiglia, Sally Temple

Science, Vol. 304, No. 5675. (28 May 2004), pp. 1338-1340.

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Abstract

Neural stem cells are reported to lie in a vascular niche, but there is no direct evidence for a functional relationship between the stem cells and blood vessel component cells. We show that endothelial cells but not vascular smooth muscle cells release soluble factors that stimulate the self-renewal of neural stem cells, inhibit their differentiation, and enhance their neuron production. Both embryonic and adult neural stem cells respond, allowing extensive production of both projection neuron and interneuron types in vitro. Endothelial coculture stimulates neuroepithelial cell contact, activating Notch and Hes 1 to promote self-renewal. These findings identify endothelial cells as a critical component of the neural stem cell niche. 10.1126/science.1095505

@article{citeulike:2501393, abstract = {Neural stem cells are reported to lie in a vascular niche, but there is no direct evidence for a functional relationship between the stem cells and blood vessel component cells. We show that endothelial cells but not vascular smooth muscle cells release soluble factors that stimulate the self-renewal of neural stem cells, inhibit their differentiation, and enhance their neuron production. Both embryonic and adult neural stem cells respond, allowing extensive production of both projection neuron and interneuron types in vitro. Endothelial coculture stimulates neuroepithelial cell contact, activating Notch and Hes 1 to promote self-renewal. These findings identify endothelial cells as a critical component of the neural stem cell niche. 10.1126/science.1095505}, author = {Shen, Qin and Goderie, Susan K. and Jin, Li and Karanth, Nithin and Sun, Yu and Abramova, Natalia and Vincent, Peter and Pumiglia, Kevin and Temple, Sally }, citeulike-article-id = {2501393}, doi = {http://dx.doi.org/10.1126/science.1095505}, journal = {Science}, keywords = {angiogenesis, differentiation, endothelia, glioblastoma, glioma, microvasculature, neurobiology, neurogenesis, niche, stem-cells, stem\_cells, stemcells}, month = {May}, number = {5675}, pages = {1338--1340}, posted-at = {2008-03-10 15:39:11}, priority = {0}, title = {Endothelial Cells Stimulate Self-Renewal and Expand Neurogenesis of Neural Stem Cells}, url = {http://dx.doi.org/10.1126/science.1095505}, volume = {304}, year = {2004} }

RIS record

TY - JOUR ID - citeulike:2501393 L3 - citeulike-article-id:2501393 TI - Endothelial Cells Stimulate Self-Renewal and Expand Neurogenesis of Neural Stem Cells JF - Science VL - 304 IS - 5675 SP - 1338 EP - 1340 N2 - Neural stem cells are reported to lie in a vascular niche, but there is no direct evidence for a functional relationship between the stem cells and blood vessel component cells. We show that endothelial cells but not vascular smooth muscle cells release soluble factors that stimulate the self-renewal of neural stem cells, inhibit their differentiation, and enhance their neuron production. Both embryonic and adult neural stem cells respond, allowing extensive production of both projection neuron and interneuron types in vitro. Endothelial coculture stimulates neuroepithelial cell contact, activating Notch and Hes 1 to promote self-renewal. These findings identify endothelial cells as a critical component of the neural stem cell niche. 10.1126/science.1095505 KW - angiogenesis KW - differentiation KW - endothelia KW - glioblastoma KW - glioma KW - microvasculature KW - neurobiology KW - neurogenesis KW - niche KW - stem-cells KW - stem_cells KW - stemcells AU - Shen, Qin AU - Goderie, Susan AU - Jin, Li AU - Karanth, Nithin AU - Sun, Yu AU - Abramova, Natalia AU - Vincent, Peter AU - Pumiglia, Kevin AU - Temple, Sally PY - 2004/05/28/ UR - http://dx.doi.org/10.1126/science.1095505 ER -

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