Functional connectivity and alterations in baseline brain state in humans Export

@article{citeulike:5310617, abstract = {This work examines the influence of changes in baseline activity on the intrinsic functional connectivity fMRI (fc-fMRI) in humans. Baseline brain activity was altered by inducing anesthesia (sevoflurane end-tidal concentration 1\%) in human volunteers and fc-fMRI maps between the pre-anesthetized and anesthetized conditions were compared across different brain networks. We particularly focused on low-level sensory areas (primary somatosensory, visual, and auditory cortices), the thalamus, and pain (insula), memory (hippocampus) circuits, and the default mode network (DMN), the latter three to examine higher-order brain regions. The results indicate that, while fc-fMRI patterns did not significantly differ ( p  < 0.005; 20-voxel cluster threshold) in sensory cortex and in the DMN between the pre- and anesthetized conditions, fc-fMRI in high-order cognitive regions (i.e. memory and pain circuits) was significantly altered by anesthesia. These findings provide further evidence that fc-fMRI reflects intrinsic brain properties, while also demonstrating that 0.5 MAC sevoflurane anesthesia preferentially modulates higher-order connections.}, author = {Martuzzi, Roberto and Ramani, Ramachandran and Qiu, Maolin and Rajeevan, Nallakkandi and Constable, R. Todd}, citeulike-article-id = {5310617}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.neuroimage.2009.07.028}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S1053811909008015}, day = {01}, doi = {10.1016/j.neuroimage.2009.07.028}, issn = {10538119}, journal = {NeuroImage}, keywords = {anesthesia, default-mode, fmri, functional-connectivity, resting-state}, month = {January}, number = {1}, pages = {823--834}, posted-at = {2009-11-04 19:35:52}, priority = {2}, title = {Functional connectivity and alterations in baseline brain state in humans}, url = {http://dx.doi.org/10.1016/j.neuroimage.2009.07.028}, volume = {49}, year = {2010} }

TY - JOUR ID - citeulike:5310617 L3 - citeulike-article-id:5310617 N2 - This work examines the influence of changes in baseline activity on the intrinsic functional connectivity fMRI (fc-fMRI) in humans. Baseline brain activity was altered by inducing anesthesia (sevoflurane end-tidal concentration 1%) in human volunteers and fc-fMRI maps between the pre-anesthetized and anesthetized conditions were compared across different brain networks. We particularly focused on low-level sensory areas (primary somatosensory, visual, and auditory cortices), the thalamus, and pain (insula), memory (hippocampus) circuits, and the default mode network (DMN), the latter three to examine higher-order brain regions. The results indicate that, while fc-fMRI patterns did not significantly differ ( p  < 0.005; 20-voxel cluster threshold) in sensory cortex and in the DMN between the pre- and anesthetized conditions, fc-fMRI in high-order cognitive regions (i.e. memory and pain circuits) was significantly altered by anesthesia. These findings provide further evidence that fc-fMRI reflects intrinsic brain properties, while also demonstrating that 0.5 MAC sevoflurane anesthesia preferentially modulates higher-order connections. IS - 1 JF - NeuroImage SN - 10538119 EP - 834 TI - Functional connectivity and alterations in baseline brain state in humans VL - 49 SP - 823 KW - anesthesia KW - default-mode KW - fmri KW - functional-connectivity KW - resting-state AU - Martuzzi, Roberto AU - Ramani, Ramachandran AU - Qiu, Maolin AU - Rajeevan, Nallakkandi AU - Constable, Todd PY - 2010/01/01/ UR - http://dx.doi.org/10.1016/j.neuroimage.2009.07.028 ER -