Sources of group differences in functional connectivity: An investigation applied to autism spectrum disorder Export

@article{citeulike:5312316, abstract = {An increasing number of fMRI studies are using the correlation of low-frequency fluctuations between brain regions, believed to reflect synchronized variations in neuronal activity, to infer ” functional connectivity”. In studies of autism spectrum disorder (ASD), decreases in this measure of connectivity have been found by focusing on the response to task modulation, by using only the rest periods, or by analyzing purely resting-state data. This difference in connectivity, however, could result from a number of different mechanisms — differences in noise, task-related fluctuations, task performance, or spontaneous neuronal activity. In this study, we investigate the difference in functional connectivity between adolescents with high-functioning ASD and typically developing control subjects by examining the residual fluctuations occurring on top of the fMRI response to an overt verbal fluency task. We find decreased correlations of these residuals (a decreased ” connectivity”) in ASD subjects. Furthermore, we find that this decrease was not due to task-related effects, block-to-block variations in task performance, or increased noise, and the difference was greatest when primarily rest periods are considered. These findings suggest that the estimate of disrupted functional connectivity in ASD is likely driven by differences in task-unrelated neuronal fluctuations.}, author = {Jones, Tyler B. and Bandettini, Peter A. and Kenworthy, Lauren and Case, Laura K. and Milleville, Shawn C. and Martin, Alex and Birn, Rasmus M.}, citeulike-article-id = {5312316}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.neuroimage.2009.07.051}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S1053811909008416}, day = {01}, doi = {10.1016/j.neuroimage.2009.07.051}, issn = {10538119}, journal = {NeuroImage}, keywords = {autism, autism\_spectrum\_disorder, fmri, functional-connectivity, resting-state}, month = {January}, number = {1}, pages = {401--414}, posted-at = {2009-11-04 19:34:21}, priority = {2}, title = {Sources of group differences in functional connectivity: An investigation applied to autism spectrum disorder}, url = {http://dx.doi.org/10.1016/j.neuroimage.2009.07.051}, volume = {49}, year = {2010} }

TY - JOUR ID - citeulike:5312316 L3 - citeulike-article-id:5312316 N2 - An increasing number of fMRI studies are using the correlation of low-frequency fluctuations between brain regions, believed to reflect synchronized variations in neuronal activity, to infer “functional connectivity”. In studies of autism spectrum disorder (ASD), decreases in this measure of connectivity have been found by focusing on the response to task modulation, by using only the rest periods, or by analyzing purely resting-state data. This difference in connectivity, however, could result from a number of different mechanisms — differences in noise, task-related fluctuations, task performance, or spontaneous neuronal activity. In this study, we investigate the difference in functional connectivity between adolescents with high-functioning ASD and typically developing control subjects by examining the residual fluctuations occurring on top of the fMRI response to an overt verbal fluency task. We find decreased correlations of these residuals (a decreased “connectivity”) in ASD subjects. Furthermore, we find that this decrease was not due to task-related effects, block-to-block variations in task performance, or increased noise, and the difference was greatest when primarily rest periods are considered. These findings suggest that the estimate of disrupted functional connectivity in ASD is likely driven by differences in task-unrelated neuronal fluctuations. IS - 1 JF - NeuroImage SN - 10538119 EP - 414 TI - Sources of group differences in functional connectivity: An investigation applied to autism spectrum disorder VL - 49 SP - 401 KW - autism KW - autism_spectrum_disorder KW - fmri KW - functional-connectivity KW - resting-state AU - Jones, Tyler AU - Bandettini, Peter AU - Kenworthy, Lauren AU - Case, Laura AU - Milleville, Shawn AU - Martin, Alex AU - Birn, Rasmus PY - 2010/01/01/ UR - http://dx.doi.org/10.1016/j.neuroimage.2009.07.051 ER -