On the Origin and Spread of an Adaptive Allele in Deer Mice Export

@article{citeulike:5664669, abstract = {Adaptation is a central focus of biology, although it can be difficult to identify both the strength and agent of selection and the underlying molecular mechanisms causing change. We studied cryptically colored deer mice living on the Nebraska Sand Hills and show that their light coloration stems from a novel banding pattern on individual hairs produced by an increase in Agouti expression caused by a cis-acting mutation (or mutations), which either is or is closely linked to a single amino acid deletion in Agouti that appears to be under selection. Furthermore, our data suggest that this derived Agouti allele arose de novo after the formation of the Sand Hills. These findings reveal one means by which genetic, developmental, and evolutionary mechanisms can drive rapid adaptation under ecological pressure. 10.1126/science.1175826}, author = {Linnen, Catherine R. and Kingsley, Evan P. and Jensen, Jeffrey D. and Hoekstra, Hopi E.}, citeulike-article-id = {5664669}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1175826}, citeulike-linkout-1 = {http://www.sciencemag.org/content/325/5944/1095.abstract}, citeulike-linkout-2 = {http://www.sciencemag.org/content/325/5944/1095.full.pdf}, citeulike-linkout-3 = {http://www.sciencemag.org/cgi/content/abstract/325/5944/1095}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/19713521}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=19713521}, day = {28}, doi = {10.1126/science.1175826}, issn = {1095-9203}, journal = {Science}, keywords = {adaptation, cis-regulatory, mammals}, month = {August}, number = {5944}, pages = {1095--1098}, posted-at = {2009-10-20 08:43:48}, priority = {2}, title = {On the Origin and Spread of an Adaptive Allele in Deer Mice}, url = {http://dx.doi.org/10.1126/science.1175826}, volume = {325}, year = {2009} }

TY - JOUR ID - citeulike:5664669 L3 - citeulike-article-id:5664669 N2 - Adaptation is a central focus of biology, although it can be difficult to identify both the strength and agent of selection and the underlying molecular mechanisms causing change. We studied cryptically colored deer mice living on the Nebraska Sand Hills and show that their light coloration stems from a novel banding pattern on individual hairs produced by an increase in Agouti expression caused by a cis-acting mutation (or mutations), which either is or is closely linked to a single amino acid deletion in Agouti that appears to be under selection. Furthermore, our data suggest that this derived Agouti allele arose de novo after the formation of the Sand Hills. These findings reveal one means by which genetic, developmental, and evolutionary mechanisms can drive rapid adaptation under ecological pressure. 10.1126/science.1175826 IS - 5944 JF - Science SN - 1095-9203 EP - 1098 TI - On the Origin and Spread of an Adaptive Allele in Deer Mice VL - 325 SP - 1095 KW - adaptation KW - cis-regulatory KW - mammals AU - Linnen, Catherine AU - Kingsley, Evan AU - Jensen, Jeffrey AU - Hoekstra, Hopi PY - 2009/08/28/ UR - http://dx.doi.org/10.1126/science.1175826 ER -