Selective inhibition of Alu retrotransposition by APOBEC3G Export

@article{citeulike:2501450, abstract = {The non-LTR retrotransposon LINE-1 (L1) comprises \~{} 17\% of the human genome, and the L1-encoded proteins can function in trans to mediate the retrotransposition of non-autonomous retrotransposons (i.e., Alu and probably SVA elements) and cellular mRNAs to generate processed pseudogenes. Here, we have examined the effect of APOBEC3G and APOBEC3F, cytidine deaminases that inhibit Vif-deficient HIV-1 replication, on Alu retrotransposition and other L1-mediated retrotransposition processes. We demonstrate that APOBEC3G selectively inhibits Alu retrotransposition in an ORF1p-independent manner. An active cytidine deaminase site is not required for the inhibition of Alu retrotransposition and the resultant integration events lack G to A or C to T hypermutation. These data demonstrate a differential restriction of L1 and Alu retrotransposition by APOBEC3G, and suggest that the Alu ribonucleoprotein complex may be targeted by APOBEC3G.}, author = {Hulme, Amy E. and Bogerd, Hal P. and Cullen, Bryan R. and Moran, John V.}, booktitle = {ASILOMAR 2006}, citeulike-article-id = {2501450}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.gene.2006.08.032}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6T39-4M0B2J1-1/2/81f1a8df6e6a356e26ace29af22b7c16}, day = {1}, doi = {10.1016/j.gene.2006.08.032}, journal = {Gene}, keywords = {alu, apobec, inhibition}, month = {April}, number = {1-2}, pages = {199--205}, posted-at = {2008-03-10 15:51:25}, priority = {0}, title = {Selective inhibition of Alu retrotransposition by APOBEC3G}, url = {http://dx.doi.org/10.1016/j.gene.2006.08.032}, volume = {390}, year = {2007} }

TY - JOUR ID - citeulike:2501450 L3 - citeulike-article-id:2501450 N2 - The non-LTR retrotransposon LINE-1 (L1) comprises ~ 17% of the human genome, and the L1-encoded proteins can function in trans to mediate the retrotransposition of non-autonomous retrotransposons (i.e., Alu and probably SVA elements) and cellular mRNAs to generate processed pseudogenes. Here, we have examined the effect of APOBEC3G and APOBEC3F, cytidine deaminases that inhibit Vif-deficient HIV-1 replication, on Alu retrotransposition and other L1-mediated retrotransposition processes. We demonstrate that APOBEC3G selectively inhibits Alu retrotransposition in an ORF1p-independent manner. An active cytidine deaminase site is not required for the inhibition of Alu retrotransposition and the resultant integration events lack G to A or C to T hypermutation. These data demonstrate a differential restriction of L1 and Alu retrotransposition by APOBEC3G, and suggest that the Alu ribonucleoprotein complex may be targeted by APOBEC3G. IS - 1-2 JF - Gene EP - 205 TI - Selective inhibition of Alu retrotransposition by APOBEC3G VL - 390 T2 - ASILOMAR 2006 SP - 199 KW - alu KW - apobec KW - inhibition AU - Hulme, Amy AU - Bogerd, Hal AU - Cullen, Bryan AU - Moran, John PY - 2007/04/01/ UR - http://dx.doi.org/10.1016/j.gene.2006.08.032 ER -